Zobrazeno 1 - 10
of 23 921
pro vyhledávání: '"chinese hamster ovary"'
Autor:
Hyun Jee Woo, Jaehoon Kim, Seul Mi Kim, Dongwoo Kim, Jae Yun Moon, Daechan Park, Jae Seong Lee
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1654-1665 (2024)
High-yield production of therapeutic protein using Chinese hamster ovary (CHO) cells requires stable cell line development (CLD). CLD typically uses random integration of transgenes; however, this results in clonal variation and subsequent laborious
Externí odkaz:
https://doaj.org/article/4adeb295d6c04db89f5a92993605699c
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract At present, biopharmaceuticals have received extensive attention from the society, among which recombinant proteins have a good growth trend and a large market share. Chinese hamster ovary (CHO) cells are the preferred mammalian system to pr
Externí odkaz:
https://doaj.org/article/c72c68b4d12a415083d7243c8a7ce8be
Autor:
Niels Bauer, Marco Boettger, Styliani Papadaki, Tanja Leitner, Stefan Klostermann, Hubert Kettenberger, Guy Georges, Vincent Larraillet, Dino Gluhacevic von Kruechten, Lars Hillringhaus, Annette Vogt, Simon Ausländer, Oliver Popp
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
We present a detailed mass spectrometric analysis of three 2 + 1 T-cell bispecific monoclonal antibodies (TCB mAbs), where an unexpected +15.9950 Da mass shift in tryptic peptides was observed. This modification was attributed to the occurrence of 5R
Externí odkaz:
https://doaj.org/article/57438583073e46798b89828262bbeaca
Autor:
Chansik Yoon, Eun‐ji Lee, Dongil Kim, Siyun Joung, Yujin Kim, Heungchae Jung, Yeon‐Gu Kim, Gyun Min Lee
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Rapid and efficient cell line development (CLD) process is essential to expedite therapeutic protein development. However, the performance of widely used glutamine‐based selection systems is limited by low selection efficiency, stringency,
Externí odkaz:
https://doaj.org/article/13334b556d7c4bc09f03606f41401c70
Publikováno v:
Tzu-Chi Medical Journal, Vol 36, Iss 3, Pp 240-250 (2024)
A range of recombinant monoclonal antibodies (rMAbs) have found application in treating diverse diseases, spanning various cancers and immune system disorders. Chinese hamster ovary (CHO) cells have emerged as the predominant choice for producing the
Externí odkaz:
https://doaj.org/article/b145dae6e5ea499ab8c05d4219238be6
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Glycosylation of recombinant proteins is a post-translational modification that affects multiple physicochemical and biological properties of proteins. As such, it is a critical quality attribute that must be carefully controlled during protein produ
Externí odkaz:
https://doaj.org/article/1fa31120c52f466697120d062fd56fd5
Autor:
Maryam Jari, Shahriyar Abdoli, Zahra Bazi, Fatemeh Tash Shamsabadi, Farnaz Roshanmehr, Majid Shahbazi
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Chinese Hamster Ovary (CHO) cells are widely employed as host cells for biopharmaceutical production. The manufacturing of biopharmaceuticals poses several challenges, including restricted growth potential and inadequate productivity of the
Externí odkaz:
https://doaj.org/article/64631f6493b44f4d9ac3d82b2570e90f
Autor:
Zhiying Yin, Tingcui Wen, Canya Fu, Junji Li, Quanjun Fang, Xiaoying Gong, Jialing You, Shuangqing Wang, Canjie Zheng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionLimited data were available on the effectivenessfour years after Homo or Hetero prime-boost with 10 μg Hansenulapolymorpha recombinant hepatitis B vaccine (HepB-HP) and 20 μgChinese hamster ovary cell HepB (HepB-CHO).MethodsA crosssecti
Externí odkaz:
https://doaj.org/article/fd8a5145130a4b0a8a1f61b7c01b1bbc
Publikováno v:
Fermentation, Vol 10, Iss 7, p 352 (2024)
Monoclonal antibodies (mAbs) used in biomedical research and therapeutic applications are primarily produced by Chinese hamster ovary (CHO) cells via fed-batch culture. The growing need for elevated quantities of biologics mandates the continual opti
Externí odkaz:
https://doaj.org/article/caba93abee264836bd6c64ce2f2f6e11
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Background: Investigating the metabolic behaviour of different cellular phenotypes, i.e., good/bad grower and/or producer, in production culture is important to identify the key metabolite(s)/pathway(s) that regulate cell growth and/or recombinant pr
Externí odkaz:
https://doaj.org/article/877f7057b0d248d7a8fdcfd78b89fe14