TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

Autor: Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas

Publikováno v: eLife, Vol 10 (2021)

Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogeni

Externí odkaz: https://doaj.org/article/f5236ab6208a49dc9d2f318dd8878eee

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

Autor: Zhen-Yuan Lin, Nicholas Borcherding, Munir R. Tanas, Colleen Fullenkamp, Katrina A. Mitchell, Nicole Merritt, Dushyandi Rajendran, Xiaomeng Zhang, Michael S. Chimenti, Keith Garcia, Anne-Claude Gingras, Kieran F. Harvey

Publikováno v: eLife, Vol 10 (2021)
eLife

Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca67e64a6f5ea878141c1809cfe32691
https://elifesciences.org/articles/62857

Mechanism of DNA binding of an unusual bacterial transcription regulator

Autor: Al-Zyoud, Walid

GabR is a chimeric transcription factor from Bacillus subtilis belonging to the GntR family of transcription factors and controls genes involved in the metabolism of gamma-aminobutyric acid (GABA). The crystal structure of GabR reveals a head-to-tail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ed4910e37063a7643d5522eb25cad19

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TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex.

Autor: Merritt N; Department of Pathology, University of Iowa, Iowa City, United States., Garcia K; Department of Pathology, University of Iowa, Iowa City, United States.; Cancer Biology Graduate Program, University of Iowa, Iowa City, United States., Rajendran D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States., Zhang X; Peter MacCallum Cancer Centre, Melbourne, Australia., Mitchell KA; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia., Borcherding N; Department of Pathology and Immunology, Washington University, St. Louis, United States., Fullenkamp C; Department of Pathology, University of Iowa, Iowa City, United States., Chimenti MS; Iowa Institute of Human Genetics, Carver College of Medicine, University of Iowa, Iowa City, United States., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, United States., Harvey KF; Peter MacCallum Cancer Centre, Melbourne, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.; Department of Anatomy and Developmental Biology and Biomedicine Discovery Institute, Monash University, Clayton, Australia., Tanas MR; Department of Pathology, University of Iowa, Iowa City, United States.; Cancer Biology Graduate Program, University of Iowa, Iowa City, United States.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, United States.; Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Iowa City, United States.

Publikováno v: ELife [Elife] 2021 Apr 29; Vol. 10. Date of Electronic Publication: 2021 Apr 29.