Zobrazeno 1 - 10
of 231
pro vyhledávání: '"chimeric antibodies"'
Autor:
Ian Fallahee, Daniel Hawiger
Publikováno v:
Antibodies, Vol 13, Iss 1, p 18 (2024)
There is tremendous interest in the production of recombinant proteins, particularly bispecific antibodies and antibody–drug conjugates for research and therapeutic use. Here, we demonstrate a highly versatile plasmid system that allows the rapid g
Externí odkaz:
https://doaj.org/article/a36e6bd057b041febf30973053bf2275
Autor:
Komei Ito, Kazunori Tagami
Publikováno v:
Clinical and Molecular Allergy, Vol 19, Iss 1, Pp 1-8 (2021)
Abstract Background Measurements of allergen-specific IgE antibodies with different manufacturers’ assays show modest or poor agreement. This study compares analytical performance of specific IgE tests for whole allergen extracts and individual all
Externí odkaz:
https://doaj.org/article/48f07c67fab440a2ba82cb218c0174cb
Publikováno v:
Медицинский совет, Vol 0, Iss 5, Pp 124-133 (2021)
TNF-α has been known since 1985. It is a multifunctional proinflammatory cytokine, synthesized mainly by monocytes and macrophages. Since its discovery, many studies have been conducted that have proven that it provides homeostatic function and regu
Externí odkaz:
https://doaj.org/article/5bdd13e60563493dbf8387b0cf54ddf1
Akademický článek
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Akademický článek
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Autor:
Jessica Bourque, Daniel Hawiger
Publikováno v:
Antibodies, Vol 11, Iss 1, p 8 (2022)
Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical too
Externí odkaz:
https://doaj.org/article/d3bd233592744dadaaac9113a54db39a
Autor:
A. S. Oksanich, T. G. Samartseva, E. B. Faizjuloev, N. F. Gavrilova, I. V. Yakovleva, V. V. Sviridov, V. V. Zverev
Publikováno v:
Журнал микробиологии, эпидемиологии и иммунобиологии, Vol 0, Iss 6, Pp 56-63 (2017)
Aim. In this study we aimed to design the universal genetic construction expressing the light and heavy chains of a chimeric antibody, to develop methodological approaches for the production of chimeric antibodies with defined specificity using the m
Externí odkaz:
https://doaj.org/article/dcd5d66bf4ca41d983aed04e590bf7e9
Autor:
Courtney A. Iberg, Daniel Hawiger
Publikováno v:
Antibodies, Vol 9, Iss 2, p 23 (2020)
The specific targeting of dendritic cells (DCs) using antigen-delivering antibodies has been established to be a highly efficient protocol for the induction of tolerance and protection from autoimmune processes in experimental autoimmune encephalomye
Externí odkaz:
https://doaj.org/article/d7d1ea3b00d74590b1cd6a4ee88392eb
Autor:
Yuki Moritoki, Koichi Tsuneyama, Yuka Nakamura, Kentaro Kikuchi, Akira Shiota, Yoshiyuki Ohsugi, Zhe-Xiong Lian, Weici Zhang, Guo-Xiang Yang, Shigeharu Ueki, Masahide Takeda, Ayumi Omokawa, Tomoo Saga, Akiko Saga, Daisuke Watanabe, Masahito Miura, Yoshiyuki Ueno, Patrick S. C. Leung, Atsushi Tanaka, M. Eric Gershwin, Makoto Hirokawa
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
There is considerable interest in expanding B cell-targeted therapies in human autoimmune diseases. However, clinical trials in human primary biliary cholangitis (PBC) using a chimeric antibody against human CD20 (hCD20) have showed limited efficacy.
Externí odkaz:
https://doaj.org/article/f4394f1c3ecc4f3cbc79176d2591c62e
Publikováno v:
Frontiers in Veterinary Science, Vol 5 (2018)
The production of recombinant antibodies has had a tremendous impact on several research fields, most prominently in biotechnology, immunology and medicine, enabling enormous advances in each. Thus far, a broad diversity of recombinant antibody (rAb)
Externí odkaz:
https://doaj.org/article/a3ddd73b517e41c986e177c58df992fb