Zobrazeno 1 - 10
of 384
pro vyhledávání: '"chemotherapeutic resistance"'
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107179- (2024)
Exosomes, small yet vital extracellular vesicles, play an integral role in intercellular communication. They transport critical components, such as proteins, lipid bilayers, DNA, RNA, and glycans, to target cells. These vesicles are crucial in modula
Externí odkaz:
https://doaj.org/article/b038d0fa5fc34ca3bcd4949bbb9a6a3e
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101650- (2024)
Chemotherapy is the most common treatment for acute lymphoblastic leukemia (ALL). However, many ALL patients eventually develop relapse and treating relapsed ALL has always been challenging. Therefore, exploring the resistance mechanism of chemothera
Externí odkaz:
https://doaj.org/article/11ff8df21c844390805b8ae55331af7b
Autor:
Wenzhe Duan, Wenwen Liu, Shengkai Xia, Yang Zhou, Mengyi Tang, Mingxin Xu, Manqing Lin, Xinyu Li, Qi Wang
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Resistance to pemetrexed (PEM), a rare chemotherapeutic agent that can efficiently cross the blood-brain barrier, limits the therapeutic efficacy for patients with lung cancer brain metastasis (BM). Aldo-keto reductase family 1 B1
Externí odkaz:
https://doaj.org/article/39a4bf8e81eb49fcbbd17cb0727bdc71
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1262-1273 (2023)
Drug resistance presents one of the major causes for the failure of cancer chemotherapy. Cancer stem-like cells (CSCs), a population of self-renewal cells with high tumorigenicity and innate chemoresistance, can survive conventional chemotherapy and
Externí odkaz:
https://doaj.org/article/c0f1a52bc7cb4219abdd1dfe1636f09a
Publikováno v:
Iraqi Journal of Hematology, Vol 12, Iss 1, Pp 88-92 (2023)
BACKGROUND: The multidrug resistance (MDR1) gene's polymorphism affects the metabolism and pharmacokinetics of chemotherapeutic agents and smooth drug resistance formation in malignancies and the current study aimed to evaluate the probable impact of
Externí odkaz:
https://doaj.org/article/2458258d083b45e49e8daca5a8f57979
Autor:
Ayumi Kanemaru, Satoru Shinriki, Mimi Kai, Kanae Tsurekawa, Kazuya Ozeki, Shota Uchino, Naoki Suenaga, Kou Yonemaru, Shunsuke Miyake, Takeshi Masuda, Ryusho Kariya, Seiji Okada, Hisashi Takeshita, Yuki Seki, Hiromu Yano, Yoshihiro Komohara, Ryoji Yoshida, Hideki Nakayama, Jian-Dong Li, Hideyuki Saito, Hirofumi Jono
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background Tumor suppressor CYLD dysfunction by loss of its expression, triggers malignant transformation, especially drug resistance and tumor invasion/metastasis. Although loss of CYLD expression is significantly associated with poor progn
Externí odkaz:
https://doaj.org/article/c45d71ac42ac4c2f8a2c50b7731b06b2
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 12, Iss 4, Pp 649-657 (2022)
Purpose: Cancer is the leading challenge to human health since the dawn of early Egyptianmanuscripts, where they found tumour from fossils in the modernized 20th century. Increasingrate of incidence and death from cancer in the past few years is thou
Externí odkaz:
https://doaj.org/article/0ace810089564110b3419c076cdaf588
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-24 (2022)
Abstract Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and some patients are advanced at the
Externí odkaz:
https://doaj.org/article/8badd32aaa4545549862e7b1c198c274
Autor:
Burcin Tezcanli Kaymaz, Nur Selvi Gunel, Fatma Sogutlu, Neslihan Pinar Ozates Ay, Yusuf Baran, Cumhur Gunduz, Cigir Biray Avci
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 25, Iss 7, Pp 904-912 (2022)
Objective(s): STATs are one of the initial targets of emerging anti-cancer agents due to their regulatory roles in survival, apoptosis, drug response, and cellular metabolism in CML. Aberrant STAT3 activity promotes malignancy, and acts as a metaboli
Externí odkaz:
https://doaj.org/article/ad167cc2cfda4ac980a8a157e2f2d7d8
Autor:
Tangming Guan, Mei Li, Yan Song, Jiayi Chen, Jiaxin Tang, Caishi Zhang, Yalei Wen, Xiao Yang, Lei Huang, Yingjie Zhu, Hongxian Wang, Ke Ding, Junxia Zheng, Haoxing Zhang, Tongzheng Liu
Publikováno v:
Advanced Science, Vol 10, Iss 11, Pp n/a-n/a (2023)
Abstract Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (
Externí odkaz:
https://doaj.org/article/2378de3cdb6043609a9dc6116b174f43