Chemoresponse of de novo Acute Myeloid Leukemia to '7+3' Induction can Be Predicted by c-Myc-facilitated Cytogenetics

Autor: Tzu-Hung Hsiao, Ren Ching Wang, Tsai-Jung Lu, Chien-Hung Shih, Yu-Chen Su, Jia-Rong Tsai, Pei-Pei Jhan, Cai-Sian Lia, Han-Ni Chuang, Kuang-Hsi Chang, Chieh-Lin Teng

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Background: Identifying patients with de novo acute myeloid leukemia (AML) who will probably respond to the “7 + 3” induction regimen remains an unsolved clinical challenge. This study aimed to identify whether c-Myc could facilitate cytogenetics

Externí odkaz: https://doaj.org/article/8c202f7fc4614b8197ae2142b0b5fe3c

Clinical utility of circulating tumor-associated cells to predict and monitor chemo-response in solid tumors

Autor: Darshana Patil, Sewanti Limaye, Amit Bhatt, Prashant Kumar, Tim Crook, Sanket Patil, Raymond L. Page, Anantbhushan Ranade, Dadasaheb Akolkar, Andrew Gaya

Publikováno v: Cancer Chemotherapy and Pharmacology

Purpose Selection of cytotoxic chemotherapy agents (CCA) based on pre-treatment evaluation of drug sensitivities is a desirable but unmet goal for personalized anticancer treatment strategies. Prior attempts to correlate in vitro Chemo-Response Profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d0f7214dbacc1bdc6195d85d090ec9
http://europepmc.org/articles/PMC7870597

Identification of Prognostic and Chemopredictive microRNAs for Non-Small-Cell Lung Cancer by Integrating SEER-Medicare Data

Autor: Chunlin Dong, Qing Ye, Yong Qian, Joseph Putila, Nancy Lan Guo, Rebecca Raese, Afshin Dowlati

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7658, p 7658 (2021)

This study developed a novel methodology to correlate genome-scale microRNA (miRNA) expression profiles in a lung squamous cell carcinoma (LUSC) cohort (n = 57) with Surveillance, Epidemiology, and End Results (SEER)-Medicare LUSC patients (n = 33,89

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa67b1239830d888cdf22466ee5de4e5

Molecular Analysis of

Autor: Siva Kumar Kolluri, Clay B. Marsh, Duaa Dukhlallah, Gangqing Hu, Qing Ye, Timothy D. Eubank, Martin C. Pearce, Nancy Lan Guo, Rehab Mohamed, Alexey V. Ivanov, Marieta Gencheva

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3752, p 3752 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 7; Pages: 3752

Our previous study found that zinc finger protein 71 (ZNF71) mRNA expression was associated with chemosensitivity and its protein expression was prognostic of non-small-cell lung cancer (NSCLC). The Krüppel associated box (KRAB) transcriptional repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d83a2978667d037da1f8050f8a9563d
https://pubmed.ncbi.nlm.nih.gov/33916522

Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer

Autor: Philip Abbosh, Elizabeth R. Plimack

Publikováno v: Bladder Cancer (Amsterdam, Netherlands)

DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944e0fe7d70c232ff25cb5715f6df882
https://doi.org/10.3233/blc-170129