Zobrazeno 1 - 10
of 1 809
pro vyhledávání: '"chemogenetics"'
Autor:
Joseph F. Welch, Gordon S. Mitchell
Publikováno v:
Experimental Physiology, Vol 109, Iss 8, Pp 1217-1237 (2024)
Abstract During mild or moderate exercise, alveolar ventilation increases in direct proportion to metabolic rate, regulating arterial CO2 pressure near resting levels. Mechanisms giving rise to the hyperpnoea of exercise are unsettled despite over a
Externí odkaz:
https://doaj.org/article/4e67b7cf7bf2479883329d87907c958f
Autor:
Muhammad O. Chohan, Amy B. Lewandowski, Rebecca N. Siegel, Kally C. O’Reilly, Jeremy Veenstra-VanderWeele
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Chronic perturbations of neuronal activity can evoke homeostatic and new setpoints for neurotransmission. Using chemogenetics to probe the relationship between neuronal cell types and behavior, we recently found reversible decreases in dopam
Externí odkaz:
https://doaj.org/article/a7a2cb1b160c426eb40e8b87cc75f30c
Autor:
Yuto Yokoi, Ayame Kubo, Kyoka Nishimura, Yuki Takamura, Yoshikazu Morishita, Masabumi Minami, Hiroshi Nomura
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract Memory retrieval can become difficult over time, but it is important to note that memories that appear to be forgotten might still be stored in the brain, as shown by their occasional spontaneous retrieval. Histamine in the central nervous s
Externí odkaz:
https://doaj.org/article/c3fd32cbbd524bfc851a9fd78573f210
Autor:
Jing‐Ting Li, Shi‐Yang Jin, Jian Hu, Ru‐Xia Xu, Jun‐Nan Xu, Zi‐Ming Li, Meng‐Ling Wang, Yi‐Wen Fu, Shi‐Han Liao, Xiao‐Wen Li, Yi‐Hua Chen, Tian‐Ming Gao, Jian‐Ming Yang
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract The mechanisms of anxiety disorders, the most common mental illness, remain incompletely characterized. The ventral hippocampus (vHPC) is critical for the expression of anxiety. However, current studies primarily focus on vHPC neurons, leavi
Externí odkaz:
https://doaj.org/article/21aed14c335e45609537d4be06bed9a1
Autor:
Shiqian Li, Yafei Wang, Miesje van der Stoel, Xin Zhou, Shrinidhi Madhusudan, Kristiina Kanerva, Van Dien Nguyen, Nazli Eskici, Vesa M. Olkkonen, You Zhou, Taneli Raivio, Elina Ikonen
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Recent developments in auxin-inducible degron (AID) technology have increased its popularity for chemogenetic control of proteolysis. However, generation of human AID cell lines is challenging, especially in human embryonic stem cells (hESCs
Externí odkaz:
https://doaj.org/article/b386292dc07c45e88b124344bcaa5ff8
Autor:
Alexandra L Jellinger, Rebecca L Suthard, Bingbing Yuan, Michelle Surets, Evan A Ruesch, Albit J Caban, Shawn Liu, Monika Shpokayte, Steve Ramirez
Publikováno v:
eLife, Vol 13 (2024)
Negative memories engage a brain and body-wide stress response in humans that can alter cognition and behavior. Prolonged stress responses induce maladaptive cellular, circuit, and systems-level changes that can lead to pathological brain states and
Externí odkaz:
https://doaj.org/article/b6adb3e97de34917a4581229510e3ced
Autor:
Nooshin Mojahed, Magdalene Adjei, Elana Qasem, Sophia Aaflaq, Temitope Adu, Jessica T. Jacobs, Ben D. Richardson, Jacob C. Nordman
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Traumatic stress, particularly during critical developmental periods such as adolescence, has been strongly linked to an increased propensity and severity of aggression. Existing literature underscores that being a victim of abuse can exacerbate aggr
Externí odkaz:
https://doaj.org/article/ca4875577d2f4619808962d36a403aeb
Autor:
Dan Wang, Di Zhao, Wentao Wang, Fengai Hu, Minghu Cui, Jing Liu, Fantao Meng, Cuilan Liu, Changyun Qiu, Dunjiang Liu, Zhicheng Xu, Yameng Wang, Yu Zhang, Wei Li, Chen Li
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1789-1801 (2024)
Social dysfunction is a risk factor for several neuropsychiatric illnesses. Previous studies have shown that the lateral septum (LS)-related pathway plays a critical role in mediating social behaviors. However, the role of the connections between the
Externí odkaz:
https://doaj.org/article/3b8602f973754d2fb3009c5563ac91a9
Publikováno v:
BMC Neuroscience, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Chronic postsurgical pain (CPP) markedly impairs patients’ quality of life. Research has shown that chronic stress may extend incisional nociception in male mice. Dopaminergic (DAergic) neurons in the ventral tegmental area (VTA
Externí odkaz:
https://doaj.org/article/22bf06834b364972b2815e85fec63205
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionChemogenetic techniques, specifically the use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), have become invaluable tools in neuroscience research. Yet, the understanding of how Gq- and Gicoupled DREADDs alter lo
Externí odkaz:
https://doaj.org/article/27938d2f02cd459bb30ec188cb51e0ff