Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply

Autor: Thomas Endres, Stefan Vielhaber, Kerstin Hallmann, Niki Karavasili, Marten Szibor, Frank Schreiber, T. M. Gainutdinov, Volkmar Lessmann, Michael Schwarzer, Zemfira Gizatullina, Torsten Doenst, Matthias Kunz, Wolfram S. Kunz, Grazyna Debska-Vielhaber, Frank N. Gellerich, Alexandra Bamberger, Hans-Jochen Heinze

Publikováno v: The journal of biological chemistry 295(14), 4383-4397 (2020). doi:10.1074/jbc.RA119.011902
The journal of biological chemistry, 295(14):4383-4397
The Journal of Biological Chemistry

Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activa

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