Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils

Autor: Sara Linse, Daniel Topgaard, Katarzyna Makasewicz, Céline Galvagnion, Christopher M. Dobson, Alexander K. Buell, Emma Sparr

Publikováno v: The Journal of Physical Chemistry Letters
Galvagnion, C, Topgaard, D, Makasewicz, K, Buell, A K, Linse, S, Sparr, E & Dobson, C M 2019, ' Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils ', Journal of Physical Chemistry Letters, vol. 10, pp. 7872-7877 . https://doi.org/10.1021/acs.jpclett.9b03005
The journal of physical chemistry letters 10(24), 7872-7877 (2019). doi:10.1021/acs.jpclett.9b03005

The deposition of coassemblies made of the small presynaptic protein, α-synuclein, and lipids in the brains of patients is the hallmark of Parkinson's disease. In this study, we used natural abundance 13C and 31P magic-angle spinning nuclear magneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8671b5a5bfe9cb4a6d14ef674ec2b8f
http://europepmc.org/articles/PMC6937551

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

Autor: Crystal M. Vander Zanden, Jacek Biernat, Emmalee M. Jones, Jaroslaw Majewski, Eckhard Mandelkow, Eva Y. Chi

Publikováno v: Scientific reports 10(1), 13324 (2020). doi:10.1038/s41598-020-70208-6
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

The aggregation of the intrinsically disordered tau protein into highly ordered β-sheet-rich fibrils is implicated in the pathogenesis of a range of neurodegenerative disorders. The mechanism of tau fibrillogenesis remains unresolved, particularly e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63999e68d67550ee0848905b96b2939f
https://bib-pubdb1.desy.de/record/452699

Membrane Morphology Modifications Induced by Hydroquinones

Autor: Liliana Marzorati, Sérgio S. Funari, Claudio Di Vitta, Vivian Rebbin

Publikováno v: Langmuir 27, 8257-8262 (2011). doi:10.1021/la200768x
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

We synthesize and characterize alkylthiohydroquinones (ATHs) in order to investigate their interactions with lipid model membranes, POPE and POPC. We observe the formation of structures with different morphologies, or curvature of the lipid bilayer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c563ee91168c0943cb29a9fc59624502
https://doi.org/10.1021/la200768x

The Role of Surface Free Energy on the Formation of Hybrid Bilayer Membranes

Autor: Anne L. Plant, John T. Woodward, Herbert Wieder, Gintaras Valincius, and A. Offenhausser, Vitalii Silin

Publikováno v: Journal of the American Chemical Society 124, 14676 (2002). doi:10.1021/ja026585

The interaction of small phospholipid vesicles with well-characterized surfaces has been studied to assess the effect of the surface free energy of the underlying monolayer on the formation of phospholipid/alkanethiol hybrid bilayer membranes (HBMs).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ecc98e6ac15a44c04c29d9cf6bad63
https://doi.org/10.1021/ja026585+

Lipidic phase membrane protein serial femtosecond crystallography

Autor: R. Bruce Doak, Karol Nass, Uwe Weierstall, Holger Fleckenstein, Ryan Coffee, Helmut Hirsemann, Benjamin Erk, Lars Gumprecht, Tomas Ekeberg, Jan Davidsson, Mark S. Hunter, Filipe R. N. C. Maia, Andreas Hartmann, Carl Caleman, Nils Kimmel, Christoph Bostedt, Weixiao Yuan Wahlgren, Joachim Ullrich, Ilme Schlichting, Erik Malmerberg, Michael J. Bogan, Dmitri Starodub, Heike Soltau, M. Marvin Seibert, Stephan Stern, John D. Bozek, John C. H. Spence, Stephan Kassemeyer, Lothar Strüder, Georg Weidenspointner, Andrew V. Martin, Thomas A. White, Günter Hauser, Saša Bajt, Gergely Katona, Raymond G. Sierra, Daniel P. DePonte, Jakob Andreasson, David Arnlund, Anton Barty, Petra Fromme, Janos Hajdu, Richard A. Kirian, Lukas Lomb, Christian Reich, Daniel Rolles, Nicola Coppola, Linda C. Johansson, Richard Neutze, Henry N. Chapman, Joachim Schulz, Cornelia B. Wunderer, Benedikt Rudek, Mengning Liang, Stefano Marchesini, Heinz Graafsma, Francesco Stellato, Nicusor Timneanu, Artem Rudenko, Miriam Barthelmess, Andrew Aquila, Peter Holl, Robert Hartmann, Xiaoyu Wang, Robert L. Shoeman, Sascha W. Epp, Christina Y. Hampton, Lutz Foucar

Publikováno v: Nature Methods
Nature methods 9, 263-265 (2012). doi:10.1038/nmeth.1867
Nature methods

X-ray free electron laser (X-FEL)-based serial femtosecond crystallography is an emerging method with potential to rapidly advance the challenging field of membrane protein structural biology. Here we recorded interpretable diffraction data from micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311240cd81b622d27fe0f402e5d593e6
https://hdl.handle.net/11858/00-001M-0000-000F-A596-A