Zobrazeno 1 - 10
of 7 095
pro vyhledávání: '"chemically-defined"'
Autor:
Oliver Birrenbach, Peter Czermak
Publikováno v:
Electronic Journal of Biotechnology, Vol 73, Iss , Pp 32-37 (2025)
Background: The efficiency of recombinant protein production in Yarrowia lipolytica is strongly influenced by the culture medium. Complex media have limited applications because the composition is undefined and variable, whereas chemically defined me
Externí odkaz:
https://doaj.org/article/70c81059f99d45f9b79bb86aa9527773
Autor:
Mohammadjafar Hashemi, Ferdous B. Finklea, Hanna Hammons, Yuan Tian, Nathan Young, Emma Kim, Caroline Halloin, Wiebke Triebert, Robert Zweigerdt, Amit Kumar Mitra, Elizabeth A. Lipke
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 423-440 (2025)
A reliable suspension-based platform for scaling engineered cardiac tissue (ECT) production from human induced pluripotent stem cells (hiPSCs) is crucial for regenerative therapies. Here, we compared the production and functionality of ECTs formed us
Externí odkaz:
https://doaj.org/article/52fce42f65614dd89c7a6701b6a9ef7b
Autor:
Kazuto Kimura, Masaya Tsukamoto, Hiroko Sugisaki, Miyuu Tanaka, Mitsuru Kuwamura, Yuki Matsumoto, Genki Ishihara, Kei Watanabe, Mika Okada, Mahito Nakanishi, Kikuya Sugiura, Shingo Hatoya
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 708-716 (2024)
Companion animals, such as felines and canines, could provide an excellent platform for translational research from veterinary to human medicine. However, the use of feline induced pluripotent stems (fiPSCs) of quality in basic or clinical research h
Externí odkaz:
https://doaj.org/article/1d90ec70e8ce495bb603d67d954053e1
Autor:
Giulia Maria Cattaneo, Ilaria Varotto-Boccazzi, Riccardo Molteni, Federico Ronchetti, Paolo Gabrieli, Jairo Alfonso Mendoza-Roldan, Domenico Otranto, Emanuele Montomoli, Claudio Bandi, Sara Epis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The development of media for cell culture is a major issue in the biopharmaceutical industry, for the production of therapeutics, immune-modulating molecules and protein antigens. Chemically defined media offer several advantages, as they ar
Externí odkaz:
https://doaj.org/article/c2f19a23ce9d43bf976f7b5c253e91e4
Autor:
Dustin Eckhardt, Jana Mueller, Jonas Friedrich, Jan-P. Klee, Irakli Sardlishvili, Lars E. Walter, Stefanie Fey, Peter Czermak, Denise Salzig
Publikováno v:
Viruses, Vol 16, Iss 11, p 1740 (2024)
Oncolytic measles virus (MeV) is a promising anti-cancer treatment. However, the production of high titers of infectious MeV (typically 107–109 TCID50 per dose) is challenging because the virus is unstable under typical production conditions. The o
Externí odkaz:
https://doaj.org/article/a3a5f0a0960a486597c8cc05fe761d76
Autor:
Pablo G. Cataldo, María Paulina Urquiza Martínez, Julio Villena, Haruki Kitazawa, Lucila Saavedra, Elvira M. Hebert
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionLevilactobacillus brevis CRL 2013, a plant-derived lactic acid bacterium (LAB) with immunomodulatory properties, has emerged as an efficient producer of γ-aminobutyric acid (GABA). Notably, not all LAB possess the ability to produce GABA
Externí odkaz:
https://doaj.org/article/73862bc6bd28494eb4d7fb5214a90969
Akademický článek
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Autor:
Hongsheng Men
Publikováno v:
Biology, Vol 13, Iss 10, p 789 (2024)
Assisted reproductive technology has revolutionized our ability to genetically manipulate, maintain and rederive laboratory animals of biomedical importance; manipulate animal reproduction or genetics to boost production of farm animals; and improve
Externí odkaz:
https://doaj.org/article/1978d7e96d174113b9cbdc812432432f
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 221-234 (2023)
Lentiviral vectors (LVVs) play a critical role in gene delivery for ex vivo gene-modified cell therapies. However, the lack of scalable LVV production methods and the high cost associated with them may limit their use. In this work, we demonstrate th
Externí odkaz:
https://doaj.org/article/48ae0660cdeb4000b997e4d9f1973ccf
Publikováno v:
Engineering in Life Sciences, Vol 24, Iss 4, Pp n/a-n/a (2024)
Abstract Innovations in viral vaccine manufacturing are crucial for pandemic preparedness and to meet ever‐rising global demands. For influenza, however, production still mainly relies on technologies established decades ago. Although modern produc
Externí odkaz:
https://doaj.org/article/3b6443a7217a4d3ab3fc613a0d6b24db