Zobrazeno 1 - 5
of 5
pro vyhledávání: '"chemical synthesis [Fluorescent Dyes]"'
Autor:
Audun Konsmo, Bettina M. Wegenast-Braun, Mikael Lindgren, Jun Zhang, Per Hammarström, Xiongyu Wu, Sofie Nyström, Alexander Sandberg, Peter Konradsson, Ulrike Obermüller
Publikováno v:
Journal of medicinal chemistry 62(4), 2038-2048 (2019). doi:10.1021/acs.jmedchem.8b01681
A fluorescent bis-styryl-benzothiadiazole (BTD) with carboxylic acid functional groups (X-34/Congo red analogue) showed lower binding affinity toward Aβ1-42 and Aβ1-40 fibrils than its neutral analogue. Hence, variable patterns of neutral OH-substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad989f8b15360e5f7a1f057e416cea1
https://pubmed.ncbi.nlm.nih.gov/30707834
https://pubmed.ncbi.nlm.nih.gov/30707834
Synthesis of a Novel Curcumin Derivative as a Potential Imaging Probe in Alzheimer's Disease Imaging
Autor:
Bettina M. Wegenast-Braun, Hubert Kalbacher, Sumbla Sheikh, Alexander Sturzu, Thomas Nägele, Stefan Heckl, Nadine A. Schilling, Christopher Weidenmaier, Ulrike Ernemann
Publikováno v:
Current Alzheimer research 16(8), 723-731 (2019). doi:10.2174/1567205016666190816130516
Background: Curcumin has been of interest in the field of Alzheimer’s disease. Early studies on transgenic mice showed promising results in the reduction of amyloid plaques.However, curcumin is very poorly soluble in aqueous solutions and not easil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1573f3a57f3944b248f80a042d7045
https://pub.dzne.de/record/141521
https://pub.dzne.de/record/141521
Autor:
Jason H. Whitfield, Joshua A. Mitchell, Colin J. Jackson, Vanessa Vongsouthi, Inmaculada Sanchez-Romero, Andreas B. Wulff, Björn Breithausen, William H. Zhang, Harald Janovjak, Susanne Schoch, Daniel Minge, Polina E. Gulakova, Michel K. Herde, Christian Henneberger
Publikováno v:
Nature chemical biology 14(9), 861-869 (2018). doi:10.1038/s41589-018-0108-2
Fluorescent sensors are an essential part of the experimental toolbox of the life sciences, where they are used ubiquitously to visualize intra- and extracellular signaling. In the brain, optical neurotransmitter sensors can shed light on temporal an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135dc023eac7f54de9f1dfb6e9a28fdd
https://pub.dzne.de/record/140151
https://pub.dzne.de/record/140151
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains
Autor:
Gerhard Mall, Christian Schön, Roland Heyny-von Haußen, Christian Czech, Jana Hölzer, Thomas Kramer, Jochen Herms, Boris Schmidt, Valerie Goetschy-Meyer, Ingrid Hilger, Jiamin Gu, Upendra Rao Anumala, Fabio Lo Monte
Publikováno v:
Bioorganic & medicinal chemistry 21(17), 5139-5144 (2013). doi:10.1016/j.bmc.2013.06.039
There is a high demand for the development of an imaging agent for neurofibrillary tangles (NFTs) detection in Alzheimer's diagnosis. In the present study, a series of rhodanine-3-acetic acids was synthesized and evaluated for fluorescence imaging of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5770513ffb9ee75d9347104ebeea3158
https://pubmed.ncbi.nlm.nih.gov/23859773
https://pubmed.ncbi.nlm.nih.gov/23859773
Autor:
Christian Schön, Valérie Goetschy, Ingrid Hilger, Tobias Bittner, Daniel Kieser, Silvia Bauer, Boris Schmidt, Henner Knust, Steffen Burgold, Roland Heyny-von Haußen, Jochen Herms, Robert Berger, Gerhard Mall, Constantin Voss, Christian Czech, Alexander Boländer, Jana Hölzer
Publikováno v:
Journal of medicinal chemistry 55(21), 9170-9180 (2012). doi:10.1021/jm300653b
The in vivo diagnosis of Alzheimer's disease (AD) is of high socioeconomic interest and remains a demanding field of research. The biopathological hallmarks of the disease are extracellular plaques consisting of aggregated β-amyloid peptides (Aβ) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb250c85f195c6a84fea52852040ac
https://pubmed.ncbi.nlm.nih.gov/22913544
https://pubmed.ncbi.nlm.nih.gov/22913544