Zobrazeno 1 - 10
of 1 242
pro vyhledávání: '"chemical proteomics"'
Autor:
Andreas Wiest, Pavel Kielkowski
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2323-2341 (2024)
Identification of interactions between proteins and natural products or similar active small molecules is crucial for understanding of their mechanism of action on a molecular level. To search elusive, often labile, and low-abundant conjugates betwee
Externí odkaz:
https://doaj.org/article/a23f01df37664466ab7e0d767cecb727
Autor:
Shinichi Sato, Shogo Miyano, Keita Nakane, Zhengyi Liu, Munehiro Kumashiro, Tomohide Saio, Yuya Tanaka, Akira Shigenaga, Chizu Fujimura, Eri Koyanagi, Hafumi Nishi, Shusuke Tomoshige, Minoru Ishikawa
Publikováno v:
Tetrahedron Chem, Vol 12, Iss , Pp 100111- (2024)
Our ex situ tyrosine bioconjugation method utilizes the oxidation of N-methylurazole by Bobbitt's salt or electrochemical activation to generate stable radicals for selective tyrosine labeling, thereby addressing the longstanding challenges in protei
Externí odkaz:
https://doaj.org/article/a0400cbecd224dc386991e75fa935f8a
Autor:
Sabrina Ninck, Thomas Klaus, Tatiana V. Kochetkova, Sarah P. Esser, Leonard Sewald, Farnusch Kaschani, Christopher Bräsen, Alexander J. Probst, Ilya V. Kublanov, Bettina Siebers, Markus Kaiser
Publikováno v:
Environmental Microbiome, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Background Microbial communities are important drivers of global biogeochemical cycles, xenobiotic detoxification, as well as organic matter decomposition. Their major metabolic role in ecosystem functioning is ensured by a unique set of enz
Externí odkaz:
https://doaj.org/article/32d68e215869443bb788502c1b606ca7
Autor:
Peng Gao, Jianyou Wang, Chong Qiu, Huimin Zhang, Chen Wang, Ying Zhang, Peng Sun, Honglin Chen, Yin Kwan Wong, Jiayun Chen, Junzhe Zhang, Huan Tang, Qiaoli Shi, Yongping Zhu, Shengnan Shen, Guang Han, Chengchao Xu, Lingyun Dai, Jigang Wang
Publikováno v:
iMeta, Vol 3, Iss 2, Pp n/a-n/a (2024)
Abstract Malaria continues to pose a serious global health threat, and artemisinin remains the core drug for global malaria control. However, the situation of malaria resistance has become increasingly severe due to the emergence and spread of artemi
Externí odkaz:
https://doaj.org/article/7c8b8c7bcffb41ec812b9bb5d61b145a
Publikováno v:
Biology, Vol 13, Iss 8, p 555 (2024)
Throughout the human lifespan, from conception to the end of life, small molecules have an intrinsic relationship with numerous physiological processes. The investigation into small-molecule targets holds significant implications for pharmacological
Externí odkaz:
https://doaj.org/article/fe92cd6aece943e687441a8c7d8c7a8c
Autor:
Tatjana Kovačević, Krunoslav Nujić, Mario Cindrić, Snježana Dragojević, Adrijana Vinter, Amela Hozić, Milan Mesić
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The process of identifying the protein targets and off-targets of a biologically active compound is of great importance in modern drug discovery. Various chemical proteomics approaches have been established for this purpose. To compare the different
Externí odkaz:
https://doaj.org/article/0e9e0eecf46f428088a5bbe0540be1c8
Autor:
Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102930- (2023)
Benzo[α]pyrene (Bap) is recognized as a ubiquitous environmental pollutant among the polycyclic aromatic hydrocarbons (PAHs) class. Previous studies have shown that the hepatotoxicity of Bap is mainly caused by its metabolites, although it remains u
Externí odkaz:
https://doaj.org/article/284c7df34a9640c194abf0b63090ec01
Autor:
Huirui Wang, Yinghui Gao, Li Wang, Yang Yu, Jiaozhen Zhang, Chunyu Liu, Yaxin Song, Haochuan Xu, Jingcheng Wang, Hongxiang Lou, Ting Dong
Publikováno v:
Journal of Advanced Research, Vol 44, Iss , Pp 213-225 (2023)
Introduction: Pulmonary fibrosis (PF) is a fatal disease with a variable and unpredictable course. Effective clinical treatment for PF remains a challenge due to low drug accumulation in lungs and imbalanced polarization of pro/anti-fibrotic macropha
Externí odkaz:
https://doaj.org/article/1a4ba08d38684c9aaf660184315166dd
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