Výsledky vyhledávání - "charge reversal"

Akademický článek

A charge reversal nano-assembly prevents hepatic steatosis by resolving inflammation and improving lipid metabolism

Autor: Haoyu Wang, Sheng'e Su, Xin An, Yuan Xu, Jiacheng Sun, Mingming Zhen, Chunru Wang, Chunli Bai

Publikováno v: Bioactive Materials, Vol 45, Iss , Pp 496-508 (2025)

Lipid metabolism imbalance combined with over-activated inflammation are two key factors for hepatic stestosis. However, on-demand anchoring inflammation and lipid metabolism disorder for hepatic stestosis treatment has yet to be realized. Here we pr

Externí odkaz: https://doaj.org/article/00f7b2e05c534103a526e62857f2cece

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Akademický článek

Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis

Autor: Shahira F. El Menshawe, Khaled Shalaby, Mohammed H. Elkomy, Heba M. Aboud, Yasmin M. Ahmed, Abdelmeged A. Abdelmeged, Marwa Elkarmalawy, Mahmoud A. Abou Alazayem, Amani M. El Sisi

Publikováno v: International Journal of Pharmaceutics: X, Vol 7, Iss , Pp 100225- (2024)

Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested potential activity against diverse types of cancer. However, low bioavailability and cardiovascular side effects remain the major challenges that limit its exploitati

Externí odkaz: https://doaj.org/article/18ff790bc59241c08c65b14e5a612d8d

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Akademický článek

Surface charge adaptive nitric oxide nanogenerator for enhanced photothermal eradication of drug-resistant biofilm infections

Autor: Huifang Ma, Yizhang Tang, Fan Rong, Kun Wang, Tengjiao Wang, Peng Li

Publikováno v: Bioactive Materials, Vol 27, Iss , Pp 154-167 (2023)

Due to protection of extracellular polymeric substances, the therapeutic efficiency of conventional antimicrobial agents is often impeded by their poor infiltration and accumulation in biofilm. Herein, one type of surface charge adaptable nitric oxid

Externí odkaz: https://doaj.org/article/287f35483cb748b78974b946aef53082

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Akademický článek

Manufacture and Characterization of Cationic Nano-fibrillated Cellulose from Cotton Pulp

Autor: Soo Hyun Lee, Hae Min Jo, Ji Young Lee

Publikováno v: BioResources, Vol 18, Iss 2, Pp 3328-3341 (2023)

The applicability of cotton-bleached soda pulp (C-BSP) was investigated as a raw material for manufacturing cationic nano-fibrillated cellulose (NFC) via quaternization of anionic NFC using glycidyl-trimethyl-ammonium chloride (GMA). The anionic NFC

Externí odkaz: https://doaj.org/article/a67a88d08d414ea6a4317f97f5fbca24

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Akademický článek

Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin

Autor: Xin Li, Laura Hetjens, Nadja Wolter, Helin Li, Xiangyang Shi, Andrij Pich

Publikováno v: Journal of Advanced Research, Vol 43, Iss , Pp 87-96 (2023)

Introduction: High-dose drug administration for the conventional treatment of inflammatory bowel disease induces cumulative toxicity and serious side effects. Currently, few reports have introduced smart carriers for intestinal inflammation targeting

Externí odkaz: https://doaj.org/article/f2f7039a7d5f4f85867f7bf6bf563dd0

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