Zobrazeno 1 - 10
of 364
pro vyhledávání: '"chagasic cardiomyopathy"'
Autor:
Alfonso Herreros-Cabello, Pau Bosch-Nicolau, José A. Pérez-Molina, Fernando Salvador, Begoña Monge-Maillo, Jose F. Rodriguez-Palomares, Antonio Luiz Pinho Ribeiro, Adrián Sánchez-Montalvá, Ester Cerdeira Sabino, Francesca F. Norman, Manuel Fresno, Núria Gironès, Israel Molina
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Untargeted metabolomic analysis is a powerful tool used for the discovery of novel biomarkers. Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical disease that affects 6–7 million people with approximately 30% develop
Externí odkaz:
https://doaj.org/article/e2cdb2426ecb4c52aa567ec32f592a06
Akademický článek
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Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Background Chronic chagasic cardiomyopathy (CCC) is the leading cause of heart failure in Latin America and often causes severe inflammation and fibrosis in the heart. Studies on myocardial function and its molecular mechanisms in patients w
Externí odkaz:
https://doaj.org/article/fa9f1df56de54bd19ad70e7f5f1c1dc4
Autor:
Kristyn A. Hoffman, Maria Jose Villar, Cristina Poveda, Maria Elena Bottazzi, Peter J. Hotez, David J. Tweardy, Kathryn M. Jones
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Chronic Chagasic cardiomyopathy (CCC) is a severe clinical manifestation that develops in 30%–40% of individuals chronically infected with the protozoal parasite Trypanosoma cruzi and is thus an important public health problem. Parasite persistence
Externí odkaz:
https://doaj.org/article/951e8090f76e47d99bfb02b20ca8f366
Autor:
Jimena Rada, Martín Donato, Federico N. Penas, Catalina Alba Soto, Ágata C. Cevey, Azul V. Pieralisi, Ricardo Gelpi, Gerardo A. Mirkin, Nora B. Goren
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
IL-10 is an anti-inflammatory cytokine that plays a significant role in the modulation of the immune response in many pathological conditions, including infectious diseases. Infection with Trypanosoma cruzi (T. cruzi), the etiological agent of Chagas
Externí odkaz:
https://doaj.org/article/789a7dcbe9e04d4498aac08b8da6b2f8
Autor:
Eduardo B. Carvalho, Isalira P. R. Ramos, Alvaro F. S. Nascimento, Guilherme V. Brasil, Debora B. Mello, Martin Oti, Michael Sammeth, Maria T. Bahia, Antonio C. Campos de Carvalho, Adriana B. Carvalho
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Background: The failure to translate preclinical results to the clinical setting is the rule, not the exception. One reason that is frequently overlooked is whether the animal model reproduces distinctive features of human disease. Another is the rep
Externí odkaz:
https://doaj.org/article/bb871b42c5ed4488b874416d203a9e39
Autor:
Nayara I. Medeiros, Bruna F. Pinto, Silvana M. Elói-Santos, Andréa Teixeira-Carvalho, Luísa M. D. Magalhães, Walderez O. Dutra, Rodrigo Correa-Oliveira, Juliana A. S. Gomes
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cyto
Externí odkaz:
https://doaj.org/article/16fba40d2891460b9969103cbccb4ccc
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 4, Pp 235-250 (2016)
Molecular mechanisms of Trypanosoma cruzi (Tc)-induced Chagasic cardiomyopathy (CCM) are not well understood. The NO-cGMP-PKG1α pathway maintains cardiac homeostasis and inotropy and may be disturbed due to phosphodiesterase (PDE5)-mediated cGMP cat
Externí odkaz:
https://doaj.org/article/c4303e43a04641769cf5fc929d8d08f0
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 3, p 132 (2020)
Background—Patients with Chagas cardiomyopathy (CC) have high mortality, and CC is a common indication for heart transplantation (HTx) in endemic countries. Chagas disease reactivation (CDR) is common after transplantation and is likely to cause ad
Externí odkaz:
https://doaj.org/article/fee7335b2b03463998215a9e8e3875cf
Autor:
Guilherme Visconde Brasil, Danúbia Silva dos Santos, Elias Ataide Mendonça, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Sandro Torrentes da Cunha, Cibele Ferreira Pimentel, Andréia de Vasconcelos-dos-Santos, Rosália Mendez-Otero, Clério Francisco de Azevedo Filho, Regina Coeli dos Santos Goldenberg, Antonio Carlos Campos de Carvalho
Publikováno v:
Cells, Vol 9, Iss 7, p 1629 (2020)
Chagas disease discovered more than a century ago remains an incurable disease. The objective of this work was to investigate the therapeutic potential of cardiomyocytes derived from mouse embryonic stem cells (CM-mESC) in a model of chronic Chagasic
Externí odkaz:
https://doaj.org/article/068743c3ef334aa0b0c4c26a616bd0ff