Výsledky vyhledávání - "cerebrovascular circulation| drug effects"

Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers

Autor: Jonas Bergquist, László Vécsei, Jakob Møller Hansen, Messoud Ashina, Anna Koldbro Hansted, Dalia Abou-Kassem, Inger Jansen-Olesen, Kumari Ubhayasekera, Mohammad Al-Mahdi Al-Karagholi

Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 2, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives
Al-Karagholi, M A-M, Hansen, J M, Abou-Kassem, D, Hansted, A K, Ubhayasekera, K, Bergquist, J, Vécsei, L, Jansen-Olesen, I & Ashina, M 2021, ' Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers ', Pharmacology Research & Perspectives, vol. 9, no. 2, e00741, pp. 1-10 . https://doi.org/10.1002/prp2.741

The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy. L‐kynurenine (LKYN), the first active metabolite in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4acdd266ebc8684b24350197376aeb
https://doaj.org/article/594ff105002f42b18f21c7e12f68f42e

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Ephedrine versus Phenylephrine Effect on Cerebral Blood Flow and Oxygen Consumption in Anesthetized Brain Tumor Patients:: A Randomized Clinical Trial

Autor: Koch, Klaus Ulrik, Mikkelsen, Irene Klærke, Aanerud, Joel Fredrik Astrup, Espelund, Ulrick, Tietze, Anna, Oettingen, Gorm von, Juul, Niels, Nikolajsen, Lone, Østergaard, Leif, Rasmussen, Mads

Publikováno v: Koch, K U, Mikkelsen, I K, Aanerud, J F A, Espelund, U, Tietze, A, Oettingen, G V, Juul, N, Nikolajsen, L, Østergaard, L & Rasmussen, M 2020, ' Ephedrine versus Phenylephrine Effect on Cerebral Blood Flow and Oxygen Consumption in Anesthetized Brain Tumor Patients: A Randomized Clinical Trial ', Anesthesiology, vol. 133, no. 2, pp. 304-317 . https://doi.org/10.1097/ALN.0000000000003377

Background: Studies in anesthetized patients suggest that phenylephrine reduces regional cerebral oxygen saturation compared with ephedrine. The present study aimed to quantify the effects of phenylephrine and ephedrine on cerebral blood flow and cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::90ac90895b24f7ba1d1b2d07ea793b55
https://pure.au.dk/portal/da/publications/ephedrine-versus-phenylephrine-effect-on-cerebral-blood-flow-and-oxygen-consumption-in-anesthetized-brain-tumor-patients(78281795-5c14-4322-b496-60d678c4beca).html

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Role of cerebral hypoperfusion in multiple sclerosis (ROCHIMS)

Autor: Ayla Pauwels, Hubert Raeymaekers, Veronique Michiels, Stéphanie Hostenbach, Miguel D'haeseleer, Anne-Marie Van Binst, Jacques De Keyser, Annick Van Merhaeghen-Wieleman, Peter Van Schuerbeek

Publikováno v: Trials, Vol 20, Iss 1, Pp 1-7 (2019)
TRIALS, 20:164. BMC
Trials

Background Axonal degeneration is related to long-term disability in patients with multiple sclerosis (MS). The underlying mechanism remains ill understood but appears to involve axonal energetic dysfunction. A globally impaired cerebral blood flow (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a49b8ce769e91a5f645f341ceb610a
https://doi.org/10.1186/s13063-019-3252-4

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Complete tachyphylaxis for vasopressin in a patient with subarachnoid haemorrhage

Autor: Thomsen, Josefine, Sprogøe, Ulrik

Publikováno v: Thomsen, J & Sprogøe, U 2019, ' Komplet takyfylaksi for vasopressor hos en patient med subaraknoidalblødning ', Ugeskrift for Laeger, bind 181, nr. 22, V01180050 . < http://ugeskriftet.dk/videnskab/komplet-takyfylaksi-vasopressor-hos-en-patient-med-subaraknoidalblodning >

In this case report, we present a 28-year-old woman who was admitted to a neuro-intensive care unit with subarachnoid haemorrhage. She was intubated and haemodynamically unstable. Over five days the need for norepinephrine reached the level of 1.2 µ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::e1b4ffe5735e4edd9d83bb55d8943bcb
https://portal.findresearcher.sdu.dk/da/publications/f3e23ca4-1ec9-4f98-84a9-810c92af0309

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Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3−/−/C57BL/6N Knockout and WT (C57BL/6N) Control Mice

Autor: Anita Matić, Mihael Mišir, Helena Justić, Zrinka Mihaljević, Ivana Jukić, Nataša Kozina, Kate Šešelja, Marina Dobrivojević Radmilović, Nikola Bijelić, Ines Drenjančević, Mirela Baus Lončar, Anita Horvatić, Edi Rođak, Iva Bazina, Martina Mihalj, Srećko Gajović

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5188 (2019)
Volume 20
Issue 20

High salt (HS) dietary intake leads to impaired vascular endothelium-dependent responses to various physiological stimuli, some of which are mediated by arachidonic acid (AA) metabolites. Transgenic Tff3&minus
/&minus
gene knockout mice (Tf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ed7aee7a8efae89922130df9edcf77
https://www.bib.irb.hr/1031619

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Correlation among decreased regional cerebral oxygen saturation, blood levels of brain injury biomarkers, and cognitive disorder

Autor: Kumpaitiene, Birute, Svagzdoeme, Milda, Drigotiene, Ingrida, Sirvinskas, Edmundas, Sepetiene, Ramune, Zakelis, Rolandas, Benetis, Rimantas

Objective This study was performed to investigate the correlation among decreased regional cerebral oxygen saturation (rSO2), blood levels of brain injury biomarkers, and postoperative cognitive disorder (POCD) after cardiac surgery with cardiopulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3368::7490a9c99977ee9bce075f9893aaba5a
https://vb.ktu.edu/KTU:ELABAPDB29434746&prefLang=en_US

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Cerebral Blood Flow Measurements in Adults

Publikováno v: Nutrients. 10(5)

Improving cerebrovascular function may be a key mechanism whereby a healthy lifestyle, of which a healthy diet combined with increased physical activity levels is a cornerstone, protects against cognitive impairments. In this respect, effects on cere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________83::825abd3fe6bad49abe832501a48c97dd
https://cris.maastrichtuniversity.nl/en/publications/ef3bd499-f01f-4b1f-8ecd-5c9a3aac5822

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