Výsledky vyhledávání - "cerebrospinal fluid [Autoantibodies]"

Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability

Autor: Yuko Fukata, Rosanna P. Sammons, Daniel Parthier, Masaki Fukata, Alexander B. Kowski, Dietmar Schmitz, Hans-Christian Kornau, Barbara Imbrosci, Jakob Kreye, Harald Prüss, Sarah Kurpjuweit, Alexander Stumpf

Publikováno v: Annals of neurology 87(3), 405-418 (2020). doi:10.1002/ana.25666

Objective Leucine-rich glioma-inactivated 1 (LGI1) encephalitis is the second most common antibody-mediated encephalopathy, but insight into the intrathecal B-cell autoimmune response, including clonal relationships, isotype distribution, frequency,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0322489a49db8b9bb4adf18b8bed3fb8
https://doi.org/10.1002/ana.25666

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Novel anti-cytoplasmic antibodies in cerebrospinal fluid and serum of patients with chronic severe mental disorders

Autor: Dominique Endres, Benjamin Pankratz, Sarah Thiem, Kimon Runge, Andrea Schlump, Bernd Feige, Kathrin Nickel, Marco Reisert, Hansjörg Mast, Horst Urbach, Miriam A. Schiele, Katharina Domschke, Benjamin Berger, Nils Venhoff, Harald Prüss, Ludger Tebartz van Elst

Publikováno v: The world journal of biological psychiatry 23(10), 794-801 (2022). doi:10.1080/15622975.2022.2042599

There is an emerging role of autoimmune causes related to severe mental disorders (SMD). The clinical approach in patients with chronic SMD and novel anti-central nervous system antibodies is complex.Two corresponding cumulative cases are presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ea8f9667ea04ec1841c156883644ad
https://pubmed.ncbi.nlm.nih.gov/35168497

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High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms

Autor: Heinrich J. Audebert, Mirja Steinbrenner, S. Momsen Reincke, Kai-Uwe Eckardt, Andrea Rocco, Harald Prüß, Elisa Sanchez-Sendin, Jonas A. Hosp, Christoph J. Ploner, Stefan Angermair, Daniel Zickler, Caroline Ferse, Christiana Franke, Jakob Kreye, Matthias Endres, Sascha Treskatsch, Rick Dersch

Publikováno v: Brain, behavior and immunity 93, 415-419 (2021). doi:10.1016/j.bbi.2020.12.022
Brain, Behavior, and Immunity

Highlights • COVID-19 patients show a broad spectrum of neurological manifestations. • SARS-CoV-2 is scarcely detected in cerebrospinal fluid. • Viral-triggered autoimmune responses may lead to neurological symptoms. • Immunotherapy should be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0def0114ffc2b49ccfe15a4a77dc5559
https://pub.dzne.de/record/155135

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Presence of anti-neuronal antibodies in children with neurological disorders beyond encephalitis

Autor: Christian Meisel, Markus Reindl, Marc Nikolaus, Angela M. Kaindl, Markus Schuelke, Harald Prüss, Jakob Kreye, Ellen Knierim

Publikováno v: European journal of paediatric neurology 28, 159-166 (2020). doi:10.1016/j.ejpn.2020.07.004

Background Anti-neuronal autoantibodies have been reported as the cause of several neurologic disorders other than encephalitis. Unfortunately, data are mostly based on serum analysis. Predictions about pathogenicity are thus limited. To determine th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7701ec40182c03337a74c44b5356d4a8

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Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis

Autor: Franziska Scheibe, Astrid Nümann, Tobias Alexander, Harald Prüss, Martin Köhnlein, Siegfried Kohler, Klemens Ruprecht, Andreas Meisel, Falk Hiepe, Annerose M. Mengel

Publikováno v: Neurology 88(4), 366-370 (2016). doi:10.1212/WNL.0000000000003536

Objective:We assessed the therapeutic potential of the plasma-cell-depleting proteasome inhibitor bortezomib in severe and therapy-refractory cases of anti–NMDA receptor (anti-NMDAR) encephalitis.Methods:Five severely affected patients with anti-NM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8499a50fd41805b9b664d98882da8f0
https://doi.org/10.1212/wnl.0000000000003536

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High prevalence of neuronal surface autoantibodies associated with cognitive deficits in cancer patients

Autor: Lutz Harms, Frederik Bartels, Carsten Finke, Harald Prüss, Alva Lütt

Publikováno v: Journal of neurology 264(9), 1968-1977 (2017). doi:10.1007/s00415-017-8582-0

The recent discovery of neuronal cell-surface antibodies profoundly expanded the clinical spectrum of paraneoplastic neurological syndromes. Many of these syndromes are associated with impaired cognitive function, a clinical symptom that is of increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544fa1dd48fcb81f16a0104b1121be01

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The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1

Autor: Castillo-Gomez, E., Kästner, A., Steiner, J., Schneider, A., Hettling, B., Poggi, G., Ostehr, K., Uhr, M., Asif, A., Matzke, M., Schmidt, U., Pfander, V., Hammer, C., Schulz, T., Binder, L., Stöcker, W., Weber, F., Ehrenreich, H.

Publikováno v: Annals of neurology 79(1), 144-151 (2015). doi:10.1002/ana.24545
Annals of Neurology

Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a82396fdf7385e8df3d832896fd836e7

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Autoantibodies Against Amyloid and Glial-Derived Antigens are Increased in Serum and Cerebrospinal Fluid of Lewy Body-Associated Dementias

Autor: Markus Langkamp, Daniela Berg, Thomas Gasser, Jana Godau, Stephanie C. Hörnig, Kathrin Brockmann, Matthis Synofzik, Walter Maetzler, Arthur Melms

Publikováno v: Journal of Alzheimer's disease 26(1), 171-179 (2011). doi:10.3233/JAD-2011-110221

There is increasing evidence that in Lewy body-associated dementias (encompassing Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB)), the adaptive immune system is altered and the degenerative process includes glial cells in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0fbfc898e4c853a930d5061eb50e70
https://doi.org/10.3233/jad-2011-110221

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Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut

Autor: Harald Prüss, Nina K. Wenke, Claudia A. Szentiks, Gábor Á. Czirják, Alex D. Greenwood, J. Leubner

Publikováno v: Scientific Reports
Scientific reports 5(1), 12805 (2015). doi:10.1038/srep12805

Knut the polar bear of the Berlin Zoological Garden drowned in 2011 following seizures and was diagnosed as having suffered encephalitis of unknown etiology after exhaustive pathogen screening. Using the diagnostic criteria applied to human patients,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8957bbf8249b55a0677dec893238f108
https://doi.org/10.1038/srep12805

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Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays

Autor: Heinzel, Sebastian, Gold, Maike, Deuschle, Christian, Bernhard, Felix, Maetzler, Walter, Berg, Daniela, Dodel, Richard

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114566 (2014)
PLoS ONE
PLOS ONE 9(12), e114566 (2014). doi:10.1371/journal.pone.0114566
PLoS ONE.-San Francisco : PloS one; 2014.-S.e114566:1-e114566:16.

Alpha-synuclein ($α$-Syn) plays a pivotal role in the pathophysiology of Parkinson's disease (PD), which can partly be modulated by innate and adaptive immune functions, and vice versa. Here, naturally occurring $α$-Syn autoantibodies ($α$-Syn-nAb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce7070661ede6c2bbe8cda855db9155e
https://doaj.org/article/741c03361ffc4984b671bad4d5cff7c2

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