Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study

Autor: Fagan, Anne M, Henson, Rachel L, Lai, Florence, Rosas, H Diana, Schupf, Nicole, Krinsky-McHale, Sharon, Silverman, Wayne, Lee, Joseph H, Klunk, William E, Handen, Benjamin L, Allegri, Ricardo F, Chhatwal, Jasmeer P, Li, Yan, Day, Gregory S, Graff-Radford, Neill R, Jucker, Mathias, Levin, Johannes, Martins, Ralph N, Masters, Colin L, Mori, Hiroshi, Mummery, Catherine J, Niimi, Yoshiki, Ringman, John M, Boerwinkle, Anna H, Salloway, Stephen, Schofield, Peter R, Shoji, Mikio, Lott, Ira T, Syndrome, Alzheimer's Biomarker Consortium-Down, Network, Dominantly Inherited Alzheimer, Xiong, Chengjie, Bateman, Randall J, Goate, Alison, Ances, Beau M, Doran, Eric, Christian, Bradley T

Publikováno v: The lancet / Neurology 20(8), 615-626 (2021). doi:10.1016/S1474-4422(21)00139-3
Lancet Neurol

Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e8e1e7a79ed1db0f682fd61a838c87
https://doi.org/10.1016/s1474-4422(21)00139-3

Signatures of glial activity can be detected in the CSF proteome

Autor: Timo Eninger, Stephan A. Müller, Mehtap Bacioglu, Manuel Schweighauser, Marius Lambert, Luis F. Maia, Jonas J. Neher, Sarah M. Hornfeck, Ulrike Obermüller, Gernot Kleinberger, Christian Haass, Philipp J. Kahle, Matthias Staufenbiel, Lingyan Ping, Duc M. Duong, Allan I. Levey, Nicholas T. Seyfried, Stefan F. Lichtenthaler, Mathias Jucker, Stephan A. Kaeser

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 119(24), e2119804119 (2022). doi:10.1073/pnas.2119804119

Single-cell transcriptomics has revealed specific glial activation states associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. While these findings may eventually lead to new therapeutic opp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba441cb791cf307fa6f069cd0a53bef0
https://pubmed.ncbi.nlm.nih.gov/35666874

Value of Neuropsychological Tests to Identify Patients with Depressive Symptoms on the Alzheimer’s Disease Continuum

Autor: Manuel Fuentes-Casañ, Carola G. Schipke, Felix Menne, Christopher F. Bauer, Arne Klostermann, Silka Dawn Freiesleben, Oliver Peters

Publikováno v: Journal of Alzheimer's disease 78(2), 819-826 (2020). doi:10.3233/JAD-200710
Journal of Alzheimer's Disease

Background: Depressive symptoms often co-occur with Alzheimer’s disease (AD) and can impact neuropsychological test results. In early stages of AD, disentangling cognitive impairments due to depression from those due to neurodegeneration often pose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cbcfc3ba395ab03dc6b7964b88a038
https://doi.org/10.3233/jad-200710

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Autor: Jansen, Willemijn J, Janssen, Olin, von Arnim, Christine, Marquié, Marta, Martinez-Lage, Pablo, Maserejian, Nancy, Mattsson, Niklas, de Mendonça, Alexandre, Meyer, Philipp T, Miller, Bruce L, Minatani, Shinobu, Mintun, Mark A, Mok, Vincent C T, Baiardi, Simone, Molinuevo, Jose Luis, Morbelli, Silvia Daniela, Morris, John C, Mroczko, Barbara, Na, Duk L, Newberg, Andrew, Nobili, Flavio, Nordberg, Agneta, Olde Rikkert, Marcel G M, de Oliveira, Catarina Resende, Baldeiras, Ines, Olivieri, Pauline, Orellana, Adela, Paraskevas, George, Parchi, Piero, Pardini, Matteo, Parnetti, Lucilla, Peters, Oliver, Poirier, Judes, Popp, Julius, Prabhakar, Sudesh, Barthel, Henryk, Rabinovici, Gil D, Ramakers, Inez H, Rami, Lorena, Reiman, Eric M, Rinne, Juha O, Rodrigue, Karen M, Rodríguez-Rodriguez, Eloy, Roe, Catherine M, Rosa-Neto, Pedro, Rosen, Howard J, Bateman, Randall J, Rot, Uros, Rowe, Christopher C, Rüther, Eckart, Ruiz, Agustín, Sabri, Osama, Sakhardande, Jayant, Sánchez-Juan, Pascual, Sando, Sigrid Botne, Santana, Isabel, Sarazin, Marie, Van Berckel, Bart, Scheltens, Philip, Schröder, Johannes, Selnes, Per, Seo, Sang Won, Silva, Dina, Skoog, Ingmar, Snyder, Peter J, Soininen, Hilkka, Sollberger, Marc, Sperling, Reisa A, Binette, Alexa Pichet, Spiru, Luisa, Stern, Yaakov, Stomrud, Erik, Takeda, Akitoshi, Teichmann, Marc, Teunissen, Charlotte E, Thompson, Louisa I, Tomassen, Jori, Tsolaki, Magda, Vandenberghe, Rik, Blennow, Kaj, Verbeek, Marcel M, Verhey, Frans R J, Villemagne, Victor, Villeneuve, Sylvia, Vogelgsang, Jonathan, Waldemar, Gunhild, Wallin, Anders, Wallin, Åsa K, Wiltfang, Jens, Wolk, David A, Boada, Merce, Yen, Tzu-Chen, Zboch, Marzena, Zetterberg, Henrik, Boecker, Henning, Tijms, Betty M, Bottlaender, Michel, den Braber, Anouk, Brooks, David J, Van Buchem, Mark A, Camus, Vincent, Carill, Jose Manuel, Cerman, Jiri, Chen, Kewei, Chételat, Gaël, Chipi, Elena, Vos, Stephanie J B, Cohen, Ann D, Daniels, Alisha, Delarue, Marion, Didic, Mira, Drzezga, Alexander, Dubois, Bruno, Eckerström, Marie, Ekblad, Laura L, Engelborghs, Sebastiaan, Epelbaum, Stéphane, Ossenkoppele, Rik, Fagan, Anne M, Fan, Yong, Fladby, Tormod, Fleisher, Adam S, Van der Flier, Wiesje M, Förster, Stefan, Fortea, Juan, Frederiksen, Kristian Steen, Freund-Levi, Yvonne, Frings, Lars, Visser, Pieter Jelle, Frisoni, Giovanni B, Fröhlich, Lutz, Gabryelewicz, Tomasz, Gertz, Hermann-Josef, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Grimmer, Timo, Guedj, Eric, Habeck, Christian G, Group, Amyloid Biomarker Study, Hampel, Harald, Handels, Ron, Hansson, Oskar, Hausner, Lucrezia, Hellwig, Sabine, Heneka, Michael, Herukka, Sanna-Kaisa, Hildebrandt, Helmut, Hodges, John, Hort, Jakub, Aarsland, Dag, Huang, Chin-Chang, Iriondo, Ane Juaristi, Itoh, Yoshiaki, Ivanoiu, Adrian, Jagust, William J, Jessen, Frank, Johannsen, Peter, Johnson, Keith A, Kandimalla, Ramesh, Kapaki, Elisabeth N, Alcolea, Daniel, Kern, Silke, Kilander, Lena, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E, Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G, Kuo, Hung-Chou, Van Laere, Koen, Landau, Susan M, Altomare, Daniele, Landeau, Brigitte, Lee, Dong Young, de Leon, Mony, Leyton, Cristian E, Lin, Kun-Ju, Lleó, Alberto, Löwenmark, Malin, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan

Publikováno v: JAMA Neurol
Jama Neurology, 79, 3, pp. 228-243
Jama Neurology, 79, 228-243
Amyloid Biomarker Study Group 2022, ' Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum ', JAMA Neurology, vol. 79, no. 3, pp. 228-243 . https://doi.org/10.1001/jamaneurol.2021.5216
JAMA Neurology, 79(3), 228-243. American Medical Association
JAMA neurology 79(3), 228-243 (2022). doi:10.1001/jamaneurol.2021.5216
Jansen, W J, Janssen, O, Tijms, B M, Vos, S J B, Ossenkoppele, R, Visser, P J & Amyloid Biomarker Study Group 2022, ' Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum ', JAMA Neurology, vol. 79, no. 3, pp. 228-243 . https://doi.org/10.1001/jamaneurol.2021.5216

Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2729bd4536737f67e3bdc3a54c881b
https://pubmed.ncbi.nlm.nih.gov/35285880

Plasma Lipocalin 2 in Alzheimer's disease: potential utility in the differential diagnosis and relationship with other biomarkers

Autor: Peter Hermann, Anna Villar-Piqué, Matthias Schmitz, Christian Schmidt, Daniela Varges, Stefan Goebel, Timothy Bunck, Hanna Lindemann, Carla Bogner, Isabel Santana, Inês Baldeiras, Joachim Riggert, Inga Zerr, Franc Llorens

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Alzheimer's Research & Therapy
Alzheimer's research & therapy 14(1), 9 (2022). doi:10.1186/s13195-021-00955-9

Background Lipocalin-2 is a glycoprotein that is involved in various physiological and pathophysiological processes. In the brain, it is expressed in response to vascular and other brain injury, as well as in Alzheimer’s disease in reactive microgl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a43e53af11ba6e5fb078fe25edbf40
https://hdl.handle.net/10316/102836