Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis

Autor: Christophe Dubois, Diane Mege, Lydie Crescence, Françoise Dignat-George, Laurence Panicot-Dubois, Léa Plantureux

Publikováno v: Cancers
Cancers, MDPI, 2018, 10 (11), pp.441. ⟨10.3390/cancers10110441⟩
Cancers, Vol 10, Iss 11, p 441 (2018)
Cancers 11 (10), . (2018)
Cancers, 2018, 10 (11), pp.441. ⟨10.3390/cancers10110441⟩

Platelets are small anucleate cells that are traditionally described as the major effectors of hemostasis and thrombosis. However, increasing evidence indicates that platelets play several roles in the progression of malignancies and in cancer-associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79d54b1b1195286ea2fbb9c80ec9df0
https://hal-amu.archives-ouvertes.fr/hal-02060202

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Autor: Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti, Damien, Alcor, Damien, Rocchi, Stephane, Cormont, Mireille, Michiels, Jean-François, Mari, Bernard, Mazure, Nathalie M., Scorrano, Luca, Lacampagne, Alain, Gharib, Abdallah, Tanti, Jean-François, Bost, Frederic

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-05052-2⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports (7), 1-9. (2017)
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.1-9. ⟨10.1038/s41598-017-05052-2⟩

International audience; Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15cac47dcff6398c094411bb601f87bc
https://hal.archives-ouvertes.fr/hal-01829816/document

Impact of adipocytes and their secretome on the effectiveness of hormone therapy in breast cancer associated with overweight

Autor: Delort, Laetitia, Decombat, Caroline, Bernard-Vermerie, Marion, Rossary, Adrien, Mojallal, Ali, Vasson, Marie-Paule, Auxenfans, Céline, Caldefie-Chezet, Florence

Publikováno v: Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017
Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017, Jun 2017, Clermont-Ferrand, France. 45 p., 2017, 4th International Congress of Translational Research in Human Nutrition & Cancer:Abstract Book
Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017, Jun 2017, Clermont-Ferrand, France. 45 p., 2017
4th International Congress of Translational Research in Human Nutrition & Cancer:Abstract Book . 2017; Fourth International Congress of Translational Research in Human Nutrition ICTRHN 2017, Clermont-Ferrand, FRA, 2017-06-22-2017-06-23, 29-29

SESSION 3 - NUTRITION AND ANTINEOPLASTIC INTERACTIONS; Obesity, an established risk factor for breast cancer in postmenopausal women, is also responsible for higher rates of recurrence and mortality. In this context, our work evaluates the impact of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a33d7cc62e75b16f56a87c3366ca6ccb
https://hal.archives-ouvertes.fr/hal-01595499

Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells

Autor: Mesclon, Florent, Lambert-Langlais, Sarah, Carraro, Valerie, Parry, Laurent, Hainault, Isabelle, Jousse, Celine, Maurin, Anne-Catherine, Bruhat, Alain, Fafournoux, Pierre, Averous, Julien

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2017, 8 (16), pp.27440-27453. ⟨10.18632/oncotarget.15828⟩
Oncotarget, 2017, 8 (16), pp.27440-27453. ⟨10.18632/oncotarget.15828⟩
Oncotarget, Impact journals, 2017, 8 (16), pp.27440-27453. 〈10.18632/oncotarget.15828〉

The uncontrolled growth of tumor can lead to the formation of area deprived in nutrients. Due to their high genetic instability, tumor cells can adapt and develop resistance to this pro-apoptotic environment. Among the resistance mechanisms, those in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a683a849f51c444dc67aa90b2246a393
https://hal.archives-ouvertes.fr/hal-01594828

A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis

Autor: David Laurent, Elodie Dardillac, François Chevalier, Jordane Depagne, Anne Bravard, Bernard S. Lopez, Yannick Saintigny, J. Pablo Radicella, Sonia Hem

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, pp.29412. ⟨10.1038/srep29412⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.29412. ⟨10.1038/srep29412⟩
Scientific Reports (6), 29412. (2016)

Endogenous stress represents a major source of genome instability, but is in essence difficult to apprehend. Incorporation of labeled radionuclides into DNA constitutes a tractable model to analyze cellular responses to endogenous attacks. Here we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbf7b591ccda10110533444b1751592
http://europepmc.org/articles/PMC4942696