Zobrazeno 1 - 10
of 405
pro vyhledávání: '"cellular phenotype"'
Autor:
Crystal C. Uwazie, Bonnie M. Pirlot, Tyler U. Faircloth, Mihir Patel, Rhett N. Parr, Halie M. Zastre, Peiman Hematti, Guido Moll, Devi Rajan, Raghavan Chinnadurai
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMesenchymal Stromal/Stem cells (MSCs) are an essential component of the regenerative and immunoregulatory stem cell compartment of the human body and thus of major importance in human physiology. The MSCs elicit their beneficial propertie
Externí odkaz:
https://doaj.org/article/c3bd537d070b4f93899c53d4c3c9f42f
Autor:
Silke D. Werle, Nensi Ikonomi, Julian D. Schwab, Johann M. Kraus, Felix M. Weidner, K. Lenhard Rudolph, Astrid S. Pfister, Rainer Schuler, Michael Kühl, Hans A. Kestler
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1603-1617 (2022)
Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes highly demanding because cellular decisions involve complex networks engaging in crosstalk interactions. Previous work on control theory indicates that smal
Externí odkaz:
https://doaj.org/article/d0b5b7f5c42942bfa222393dd1bb697b
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-11 (2020)
Abstract Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatm
Externí odkaz:
https://doaj.org/article/30acaecf440642299492440c83186cab
Stationary moments, distribution conjugation and phenotypic regions in stochastic gene transcription
Autor:
Jiajun Zhang, Tianshou Zhou
Publikováno v:
Mathematical Biosciences and Engineering, Vol 16, Iss 5, Pp 6134-6166 (2019)
Transcription is a pivotal step in gene expression yet a complex biochemical process. It occurs often in a bursty manner, leading to cell-to-cell variability important for the cells surviving in complex environments. Quantitative experiments of such
Externí odkaz:
https://doaj.org/article/2146f175c6784500b050bfa1c8af3feb
Autor:
Qingwu Wu, Jianning Chen, Yong Ren, Huijun Qiu, Lianxiong Yuan, Huiyi Deng, Yana Zhang, Rui Zheng, Haiyu Hong, Yueqi Sun, Xinyue Wang, Xuekun Huang, Chunkui Shao, Haotian Lin, Lanqing Han, Qintai Yang
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103336- (2021)
Background: artificial intelligence (AI) for cellular phenotyping diagnosis of nasal polyps by whole-slide imaging (WSI) is lacking. We aim to establish an AI chronic rhinosinusitis evaluation platform 2.0 (AICEP 2.0) to obtain the proportion of infl
Externí odkaz:
https://doaj.org/article/cb6bb5e8a32f43ea9f419123e2ac94d2
Publikováno v:
Physiological Reports, Vol 9, Iss 2, Pp n/a-n/a (2021)
Abstract Skeletal muscle regeneration is a complex process influenced by non‐myogenic macrophages and fibroblasts, which acquire different phenotypes in response to changes in the injury milieu or changes in experimental conditions. In vitro, serum
Externí odkaz:
https://doaj.org/article/fc8e0620eeb140179ee7801c08a48629
Akademický článek
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Autor:
John C. Nolan, Manuela Salvucci, Steven Carberry, Ana Barat, Miguel F. Segura, Justine Fenn, Jochen H. M. Prehn, Raymond L. Stallings, Olga Piskareva
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Neuroblastoma (NB) is a neural crest-derived tumor, which develops before birth or in early childhood, with metastatic dissemination typically preceding diagnosis. Tumors are characterized by a highly heterogeneous combination of cellular phenotypes
Externí odkaz:
https://doaj.org/article/e46c540f212a41c980fbfb4b8abc1d28
Publikováno v:
Cells, Vol 10, Iss 8, p 1963 (2021)
The zebrafish provided an excellent platform to study the genetic and molecular approach of cellular phenotype-based cardiac research. We designed a novel protocol to develop the transparent transgenic zebrafish model to study annexin-5 activity in t
Externí odkaz:
https://doaj.org/article/e8f99d74c0864c2fa6c4ef85a1ae3df6
Autor:
Martijn van Hagen, Diewertje G. E. Piebes, Wim C. de Leeuw, Ilona M. Vuist, Willeke M. C. van Roon-Mom, Perry D. Moerland, Pernette J. Verschure
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the Huntingtin (HTT) gene. Proteolytic cleavage of mutant huntingtin (Htt) protein with an expanded polyglutamine (polyQ) stretch resul
Externí odkaz:
https://doaj.org/article/a54dab9567d84dc799e44df66c09ab34