Zobrazeno 1 - 10
of 134
pro vyhledávání: '"cell wall integrity pathway"'
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 36, Iss 10, Pp 608-622 (2023)
The fungal cell wall is the first layer exposed to the external environment. The cell wall has key roles in regulating cell functions, such as cellular stability, permeability, and protection against stress. Understanding the structure of the cell wa
Externí odkaz:
https://doaj.org/article/d197862bacf74cffa0737a0de6080174
Autor:
Vladimir Vélez-Segarra, Sahily González-Crespo, Ednalise Santiago-Cartagena, Luis E. Vázquez-Quiñones, Nelson Martínez-Matías, Yamirelis Otero, Julián J. Zayas, Rafael Siaca, Jeanmadi del Rosario, Inoushka Mejías, José J. Aponte, Noelani C. Collazo, Francisco J. Lasso, Jamie Snider, Matthew Jessulat, Hiroyuki Aoki, Brian C. Rymond, Mohan Babu, Igor Stagljar, José R. Rodríguez-Medina
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3121-3135 (2020)
Antifungal drug discovery and design is very challenging because of the considerable similarities in genetic features and metabolic pathways between fungi and humans. However, cell wall composition represents a notable point of divergence. Therefore,
Externí odkaz:
https://doaj.org/article/213888786ea440eeb78f0cdc64041d9e
Autor:
Meihua Xie, Jiangliu Yang, Kexin Jiang, Na Bai, Meichen Zhu, Yingmei Zhu, Ke-Qin Zhang, Jinkui Yang
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The cell wall integrity (CWI) pathway is composed of three mitogen-activated protein kinases (MAPKs), Bck1, Mkk1/2, and Slt2, and is one of the main signaling pathways for fungal pathogenesis, cell wall synthesis, and integrity maintenance. In this s
Externí odkaz:
https://doaj.org/article/5cedda15a32445f49b1643401c1bb60f
Publikováno v:
Journal of Fungi, Vol 8, Iss 7, p 754 (2022)
Fludioxonil belongs to the phenylpyrrole group of fungicides with a broad antifungal spectrum that has been widely used in agricultural practices for the past thirty years. Although fludioxonil is known to exert its fungicidal action through group II
Externí odkaz:
https://doaj.org/article/e9d60da95ecf4357b53c82e200968db8
Autor:
Inbal Herold, Avihai Zolti, Marisela Garduño-Rosales, Zheng Wang, Francesc López-Giráldez, Rosa R. Mouriño-Pérez, Jeffrey P. Townsend, Igor Ulitsky, Oded Yarden
Publikováno v:
Frontiers in Fungal Biology, Vol 2 (2021)
The Neurospora crassa GUL-1 is part of the COT-1 pathway, which plays key roles in regulating polar hyphal growth and cell wall remodeling. We show that GUL-1 is a bona fide RNA-binding protein (RBP) that can associate with 828 “core” mRNA specie
Externí odkaz:
https://doaj.org/article/8fdaafa010c1432db0ce2bfb6755e92f
Autor:
Gema González-Rubio, Lucía Sastre-Vergara, María Molina, Humberto Martín, Teresa Fernández-Acero
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 368 (2022)
The cell wall integrity (CWI) MAPK pathway of budding yeast Saccharomyces cerevisiae is specialized in responding to cell wall damage, but ongoing research shows that it participates in many other stressful conditions, suggesting that it has function
Externí odkaz:
https://doaj.org/article/ea57096b24d04e288ca809371e8b4831
Akademický článek
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Autor:
Siddharth K. Tripathi, Qin Feng, Li Liu, David E. Levin, Kuldeep K. Roy, Robert J. Doerksen, Scott R. Baerson, Xiaomin Shi, Xuewen Pan, Wen-Hui Xu, Xing-Cong Li, Alice M. Clark, Ameeta K. Agarwal
Publikováno v:
mSphere, Vol 5, Iss 1 (2020)
ABSTRACT The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance. A promising strat
Externí odkaz:
https://doaj.org/article/5135f27089314ab884d2181bb1856ca4
Autor:
Eliciane Cevolani Mattos, Lilian Pereira Silva, Clara Valero, Patrícia Alves de Castro, Thaila Fernanda dos Reis, Liliane F. C. Ribeiro, Mark R. Marten, Rafael Silva-Rocha, Cauã Westmann, Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft, Narjes Al-Furaiji, Michael Bromley, Uffe H. Mortensen, J. Philipp Benz, Neil Andrew Brown, Gustavo H. Goldman
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The mitogen-activated protein
Externí odkaz:
https://doaj.org/article/e4362aac315c465db4926930d9ce17bc
Autor:
Anne G. Rosenwald, Gaurav Arora, Rocco Ferrandino, Erica L. Gerace, Maedeh Mohammednetej, Waseem Nosair, Shemona Rattila, Amanda Zirzow Subic, Ronda Rolfes
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 9, Pp 2893-2907 (2016)
Candida glabrata is an important human fungal pathogen whose incidence continues to rise. Because many clinical isolates are resistant to azole drugs, the drugs of choice to treat such infections are members of the echinocandin family, although there
Externí odkaz:
https://doaj.org/article/c060a17cd8934596892a33126dbe2d34