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of 138
pro vyhledávání: '"cell surface GRP78"'
Akademický článek
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Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Diabetic kidney disease (DKD) is the leading cause of kidney failure in North America, characterized by glomerular accumulation of extracellular matrix (ECM) proteins. High glucose (HG) induction of glomerular mesangial cell (MC) profib
Externí odkaz:
https://doaj.org/article/7ee73d3682f046c392fd02c6dd0948a9
Autor:
Gustavo Rico-Llanos, Óscar Porras-Perales, Sandra Escalante, Daniel B. Vázquez-Calero, Lucía Valiente, María I. Castillo, José Miguel Pérez-Tejeiro, David Baglietto-Vargas, José Becerra, José María Reguera, Ivan Duran, Fabiana Csukasi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammation is a central pathogenic feature of the acute respiratory distress syndrome (ARDS) in COVID-19. Previous pathologies such as diabetes, autoimmune or cardiovascular diseases become risk factors for the severe hyperinflammatory syndrome. A
Externí odkaz:
https://doaj.org/article/4dafb99f08e741cf8cd73e3548b14ce6
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2247 (2022)
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. Characterized by overproduction and accumulation of extracellular matrix (ECM) proteins, glomerular sclerosis is its earliest manifestation. High glucose (HG) plays a cen
Externí odkaz:
https://doaj.org/article/0aad5278e68e4392a5815b2be2161b9c
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jackie Trink, Renzhong Li, Yaseelan Palarasah, Stéphan Troyanov, Thomas E. Andersen, Johannes J. Sidelmann, Mark D. Inman, Salvatore V. Pizzo, Bo Gao, Joan C. Krepinsky
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1112 (2021)
Diabetic kidney disease (DKD) is caused by the overproduction of extracellular matrix proteins (ECM) by glomerular mesangial cells (MCs). We previously showed that high glucose (HG) induces cell surface translocation of GRP78 (csGRP78), mediating PI3
Externí odkaz:
https://doaj.org/article/a4a52abce55648158b7ad8d3e885382e
Autor:
Asfia Soomro, Jackie Trink, Kian O’Neil, Renzhong Li, Safaa Naiel, Bo Gao, Kjetil Ask, Joan C. Krepinsky
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2839 (2021)
Diabetic kidney disease (DKD) is the leading cause of kidney failure. RhoA/Rho-associated protein kinase (ROCK) signaling is a recognized mediator of its pathogenesis, largely through mediating the profibrotic response. While RhoA activation is not f
Externí odkaz:
https://doaj.org/article/7fa078df92474d5aa8ec31cadb5387f6
Publikováno v:
Cancer letters, Vol. 524 (2021) pp. 1-14
Glucose-related protein 78 (GRP78) is a chaperone protein localized primarily in the endoplasmic reticulum (ER) lumen, where it helps in proper protein folding by targeting misfolded proteins and facilitating protein assembly. In stressed cells, GRP7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3043a05a67a8f5960df8242b73a163
https://doi.org/10.1016/j.canlet.2021.10.004
https://doi.org/10.1016/j.canlet.2021.10.004
Autor:
Trink, Jacqueline
Diabetic kidney disease (DKD) is the leading cause of end stage renal disease worldwide and occurs in up to 40% of patients with diabetes. The standard of care for DKD treatment has not kept up with the current health epidemic, which has led to a hea
Externí odkaz:
http://hdl.handle.net/11375/28806
Autor:
Chen, Jack
Atherothrombosis is the underlying contributor of cardiovascular disease whereby the thrombotic events following atherosclerotic plaque rupture are linked to tissue factor (TF) and its procoagulant activity (PCA). We have reported previously that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1154::6f48d7ab731349e513998b4ca9b4aaeb
http://hdl.handle.net/11375/28283
http://hdl.handle.net/11375/28283