Myricetin stimulates the absorption of the pro-carcinogen PhIP

Autor: Ivonne M.C.M. Rietjens, John P. Groten, Maaike E. Schutte, Gerrit M. Alink, Johannes J.M. van de Sandt

Publikováno v: Cancer Letters, 231(1), 36-42
Cancer Letters 231 (2006) 1
Cancer Letters, 1, 231, 36-42

The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb30d28cbc44e0b7208462b995e5991
https://doi.org/10.1016/j.canlet.2005.01.020

Human myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 response

Autor: Carlos F. Narváez, Luz-Stella Rodríguez, Manuel A. Franco, Juana Angel, Olga Lucía Rojas

Publikováno v: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

We have previously shown that human myeloid dendritic cells treated with purified rotavirus induce an allogenic Th1 response. To determine if rotavirus in the context of an intestinal microenvironment modulates the function of dendritic cells, we tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913dc7908c29b7daf73cf335f96a980b
https://repository.urosario.edu.co/handle/10336/23645

Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats

Autor: Judith C.H. Vaessen, Gerrit M. Alink, Maaike E. Schutte, Johannes J.M. van de Sandt, Bert Spenkelink, Ivonne M.C.M. Rietjens, Andreas P. Freidig, John P. Groten

Publikováno v: Food and Chemical Toxicology, 11, 46, 3422-3428
Food and Chemical Toxicology 46 (2008) 11
Food and Chemical Toxicology, 46(11), 3422-3428

This study investigates whether the previous observation that quercetin increases the transport of PhIP through Caco-2 monolayers in vitro could be confirmed in an in vivo rat model. Co-administration of 1.45 μmol PhIP/kg bw and 30 μmol quercetin/k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f5f5c445d6f575dd3c711e8b339da
https://pubmed.ncbi.nlm.nih.gov/18783729

Pathway and single gene analyses of inhibited Caco-2 differentiation by ascorbate-stabilized quercetin suggest enhancement of cellular processes associated with development of colon cancer

Autor: Rob H. Stierum, Marjan J. van Erk, Chantal Tilburgs, Ruud Woutersen, Ashwin A. Dihal, Ivonne M.C.M. Rietjens

Publikováno v: Molecular Nutrition & Food Research 51 (2007) 8
Molecular Nutrition & Food Research, 51(8), 1031-1045
Molecular Nutrition and Food Research, 8, 51, 1031-1045

The aim was to investigate mechanisms contributing to quercetin's previously described effects on cell-proliferation and -differentiation, which contradicted its proposed anticarcinogenic potency. In a 10-day experiment, 40 μM quercetin stabilized b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f61e8f89abca59293e3c27db453f295
https://research.wur.nl/en/publications/pathway-and-single-gene-analyses-of-inhibited-caco-2-differentiat

Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in caco-2 cells

Autor: Peter J. van Bladeren, Jacques Vervoort, Nicole H.P. Cnubben, Marelle G. Boersma, Ivonne M.C.M. Rietjens, Heleen M. Wortelboer, Mustafa Usta

Publikováno v: Chemical Research in Toxicology, 12, 20, 1895-1902
Chemical Research in Toxicology 20 (2007) 12
Chemical Research in Toxicology, 20(12), 1895-1902

Curcumin, an α,β-unsaturated carbonyl compound, reacts with glutathione, leading to the formation of two monoglutathionyl curcumin conjugates. In the present study, the structures of both glutathione conjugates of curcumin were identified by LC-MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5104caffa945aab4299f43eb2d3826
http://resolver.tudelft.nl/uuid:99a49911-d15b-4d56-b82a-cc6d7cdfbe08