Chemical Composition of Aspidosperma ulei Markgr. and Antiplasmodial Activity of Selected Indole Alkaloids

Autor: Edilberto R. Silveira, Daniel Esdras de Andrade Uchoa, Marne Carvalho de Vasconcellos, Zelina Estevam dos Santos Torres, Luiz Francisco Rocha e Silva, Emerson Silva Lima, Adrian Martin Pohlit, Raimundo Braz Filho

Publikováno v: Molecules
Repositório Institucional do INPA
Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
Molecules; Volume 18; Issue 6; Pages: 6281-6297
Molecules, Vol 18, Iss 6, Pp 6281-6297 (2013)

A new indole alkaloid, 12-hydroxy-N-acetyl-21(N)-dehydroplumeran-18-oic acid (13), and 11 known indole alkaloids: 3,4,5,6-tetradehydro-β-yohimbine (3), 19(E)- hunteracine (4), β-yohimbine (5), yohimbine (6), 19,20-dehydro-17-α-yohimbine (7), ulein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09c5b9e5b0a96d87eb8e1d5c8c77487
http://europepmc.org/articles/PMC6270234

Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes

Autor: Georgiades, Savvas N., Mak, L. H., Angurell, I., Rosivatz, E., Firouz Mohd Mustapa, M., Polychroni, Christoulla, Woscholski, R., Vilar, R.

Publikováno v: Journal of Biological Inorganic Chemistry
J.Biol.Inorg.Chem.

The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find applications as tools for re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bbe852fee539f1e967e0ea055122253
https://doi.org/10.1007/s00775-010-0716-0

KIF2beta , a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation

Autor: Santama, Niovi, Krijnse-Ĺocker, J., Griffiths, G., Noda, Y., Hirokawa, N., Dotti, C. G.

Publikováno v: EMBO Journal
EMBO J.

Lysosomes concentrate juxtanuclearly in the region around the microtubule-organizing center by interaction with microtubules. Different experimental and physiological conditions can induce these organelles to move to the cell periphery by a mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca69135a1f7e0e856d855864917c3cc
https://doi.org/10.1093/emboj/17.20.5855

The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress

Autor: Gallo, L.I., Lagadari, M., Piwien-Pilipuk, G., Galigniana, M.D.

Publikováno v: J. Biol. Chem. 2011;286(34):30152-30160
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker Mito-Tracker. Signal specificity was tested with different antibodies and by FKBP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::c5aeb314fb92b0677b22a8237801dcd8

New algorithm to determine true colocalization in combination with image restoration and time-lapse confocal microscopy to map Kinases in mitochondria

Autor: Villalta, J.I., Galli, S., Iacaruso, M.F., Arciuch, V.G.A., Poderoso, J.J., Jares-Erijman, E.A., Pietrasanta, L.I.

Publikováno v: PLoS ONE 2011;6(4)
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

The subcellular localization and physiological functions of biomolecules are closely related and thus it is crucial to precisely determine the distribution of different molecules inside the intracellular structures. This is frequently accomplished by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::1046f5e71e7c0b535e70ce5d67392b99