Zobrazeno 1 - 10
of 6 942
pro vyhledávání: '"cell penetrating peptide"'
Autor:
Aref Farokhi-Fard, Saman Rahmati, Negin Sadat Hashemi Aval, Farzaneh Barkhordari, Elham Bayat, Samira Komijani, Hooman Aghamirza Moghim Aliabadi, Fatemeh Davami
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Acute myeloid leukemia (AML) is an aggressive blood cancer with frequently poor clinical outcomes. This heterogeneous malignancy encompasses genetically, molecularly, and even clinically different subgroups. This makes it difficult to develo
Externí odkaz:
https://doaj.org/article/f45f88964e0242f580addbf0aa888e74
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 9195-9211 (2024)
Ji-Hyun Kang,1,2,* Jin-Hyuk Jeong,1,* Yong-Bin Kwon,1 Young-Jin Kim,1 Dae Hwan Shin,1 Yun-Sang Park,3 Soonsil Hyun,1 Dong-Wook Kim,4 Chun-Woong Park1 1College of Pharmacy, Chungbuk National University, Cheongju, 28160, Republic of Korea; 2Sch
Externí odkaz:
https://doaj.org/article/f958982a22f0456c9a651005f1c2341c
Autor:
Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara, Sepideh Afshar
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The primary hurdles for small interference RNA (siRNA) in clinical use are targeted and cytosolic delivery. To overcome both challenges, we have established a novel platform based on phage display, called NNJA. In this approach, a lysosomal
Externí odkaz:
https://doaj.org/article/6e30468b1d324604beec000ab63fc69b
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Autodynamic cancer therapy possesses tremendous potential for enhancing therapeutic efficacy by initiating the treatment process autonomously within targeted cells. However, challenges related to biocompatibility and targeted delivery have h
Externí odkaz:
https://doaj.org/article/80b32b86ed0e41eeb2cce4136b37712a
Autor:
Maud Auger, Luis Sorroza-Martinez, Nadine Brahiti, Carole-Ann Huppé, Laurence Faucher-Giguère, Imen Arbi, Maxime Hervault, Xue Cheng, Bruno Gaillet, Frédéric Couture, David Guay, Al-Halifa Soultan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102290- (2024)
Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that protect the lungs and the endosomal entrapment phenomenon, which prevents ASOs from reaching their intracellular targets. Vario
Externí odkaz:
https://doaj.org/article/aa9af6d9fa10459b94b6f48a2b6b7dac
Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background The exogenous delivery of miRNA to mimic and restore miRNA-34a activity in various cancer models holds significant promise in cancer treatment. Nevertheless, its effectiveness is often impeded by challenges, including a short half
Externí odkaz:
https://doaj.org/article/d8f88be1330842fbaaca5ff448507bb2
Autor:
Suyang Wang, Michelle Cheng, Chao-Cheng Chen, Chia-Yu Chang, Ya-Chea Tsai, Jr-Ming Yang, TC Wu, Chuan-Hsiang Huang, Chien-Fu Hung
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTBacteria-based cancer therapy employs various strategies to combat tumors, one of which is delivering tumor-associated antigen (TAA) to generate specific immunity. Here, we utilized a poly-arginine extended HPV E7 antigen (9RE7) for attachmen
Externí odkaz:
https://doaj.org/article/7cfdbd13bc2c4b00a9e47df279922ed5
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Arginine‐rich cell‐penetrating peptides (CPPs) have emerged as valuable tools for the intracellular delivery of bioactive molecules, but their membrane perturbation during cell penetration is not fully understood. Here, nona‐arginine (
Externí odkaz:
https://doaj.org/article/d78a72121d304098a6018947327c0945
Autor:
Yasaman Behzadipour, Shiva Hemmati
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116910- (2024)
Therapeutic proteins provided new opportunities for patients and high sales volumes. However, they are formulated for extracellular targets. The lipophilic barrier of the plasma membrane renders the vast array of intracellular targets out of reach. P
Externí odkaz:
https://doaj.org/article/875ff878ff134928b69d4dc1dfbfcff1
Autor:
Lucia Adriana Lifshits, Yoav Breuer, Marina Sova, Sumit Gupta, Dar Kadosh, Evgeny Weinberg, Zvi Hayouka, Daniel Z. Bar, Maayan Gal
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cell-penetrating peptides show promise as versatile tools for intracellular delivery of therapeutic agents. Various peptides have originated from natural proteins with antimicrobial activity. We investigated the mammalian cell-penetrating pr
Externí odkaz:
https://doaj.org/article/f0784c1b3cec40f795b56147d934ee01