Zobrazeno 1 - 10
of 2 085
pro vyhledávání: '"cell identity"'
Autor:
Yusi Fu, Swati Agrawal, Daniel R. Snyder, Shiwei Yin, Na Zhong, James A. Grunkemeyer, Nicholas Dietz, Ryan Corlett, Laura A. Hansen, Al-Refaie Waddah, Kalyana C. Nandipati, Jun Xia
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-6 (2024)
Abstract The incidence of esophageal adenocarcinoma (EAC) has surged by 600% in recent decades, with a dismal 5-year survival rate of just 15%. Barrett’s esophagus (BE), affecting about 2% of the population, raises the risk of EAC by 40-fold. Despi
Externí odkaz:
https://doaj.org/article/d755409d515c417a8de21389e4f099ea
Autor:
Adam Tisch, Siddharth Madapoosi, Stephen Blough, Jan Rosa, Sean Eddy, Laura Mariani, Abhijit Naik, Christine Limonte, Philip McCown, Rajasree Menon, Sylvia E. Rosas, Chirag R. Parikh, Matthias Kretzler, Ahmed Mahfouz, Fadhl Alakwaa
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38567- (2024)
Introduction: Single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) provide valuable insights into the cellular states of kidney cells. However, the annotation of cell types often requires extensive domain expertise and
Externí odkaz:
https://doaj.org/article/356b7649853b4c9796e523f9be84a88b
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 3, Pp 144-161 (2024)
Abstract Precision in the establishment and maintenance of cellular identities is crucial for the development of multicellular organisms and requires tight regulation of gene expression. While extensive research has focused on understanding cell type
Externí odkaz:
https://doaj.org/article/4c8d1ce2da324abd8138a54f285ee6a3
Publikováno v:
Cell Insight, Vol 3, Iss 2, Pp 100151- (2024)
Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are heri
Externí odkaz:
https://doaj.org/article/22d074ddc9164b66afb301575015ea3e
Autor:
Valentina Nale, Alice Chiodi, Noemi Di Nanni, Ingrid Cifola, Marco Moscatelli, Cinzia Cocola, Matteo Gnocchi, Eleonora Piscitelli, Ada Sula, Ileana Zucchi, Rolland Reinbold, Luciano Milanesi, Alessandra Mezzelani, Paride Pelucchi, Ettore Mosca
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Introduction Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatments. Such tumors typically con
Externí odkaz:
https://doaj.org/article/f5fb666a746d4a0c9efa37c72f66cf11
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4720 (2024)
The main hallmark in the development of both type 1 and type 2 diabetes is a decline in functional β-cell mass. This decline is predominantly attributed to β-cell death, although recent findings suggest that the loss of β-cell identity may also co
Externí odkaz:
https://doaj.org/article/b89e9f9d44e7411787b8c323dfa099f4
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/ab8b2aa58cbd45e0935b73736c9888a4
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 5, Pp n/a-n/a (2023)
Abstract Peripheral immune cells play important roles in the maintenance of systemic and microenvironmental hemostasis. Measurements of circulating blood cells by single‐cell RNA sequencing (scRNA‐seq) were proposed as one of the routine measures
Externí odkaz:
https://doaj.org/article/c4fea8f541394f218b2028ee87546698
Autor:
Hani Jieun Kim, Michelle O’Hara-Wright, Daniel Kim, To Ha Loi, Benjamin Y. Lim, Robyn V. Jamieson, Anai Gonzalez-Cordero, Pengyi Yang
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 175-189 (2023)
Summary: Characterizing cell identity in complex tissues such as the human retina is essential for studying its development and disease. While retinal organoids derived from pluripotent stem cells have been widely used to model development and diseas
Externí odkaz:
https://doaj.org/article/ee3beb06dd65444dba96d1a761b4dc4b
Autor:
Yura Song, Marco Fioramonti, Gaëlle Bouvencourt, Christine Dubois, Cédric Blanpain, Alexandra Van Keymeulen
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17842- (2023)
The mammary gland (MG) is composed of three main epithelial lineages, the basal cells (BC), the estrogen receptor (ER) positive luminal cells (ER+ LC), and the ER negative LC (ER− LC). Defining the cell identity of each lineage and how it is modula
Externí odkaz:
https://doaj.org/article/6e6b4d9c9fa04244a4d24c6535fd6b0d