Zobrazeno 1 - 10
of 84
pro vyhledávání: '"cell deconvolution"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-6 (2024)
Abstract Background In this study, we present a novel method for reference-based cell deconvolution using data from DNA methylation arrays. Different from existing methods like IDOL-Ext, which operate on probe-level data, our approach represents feat
Externí odkaz:
https://doaj.org/article/e9624c6364b34cebaff7a37bd2ca63eb
Autor:
Marcelo Hurtado, Leila Khajavi, Abdelmounim Essabbar, Michael Kammer, Ting Xie, Alexis Coullomb, Anne Pradines, Anne Casanova, Anna Kruczynski, Sandrine Gouin, Estelle Clermont, Léa Boutillet, Maria Fernanda Senosain, Yong Zou, Shillin Zhao, Prosper Burq, Abderrahim Mahfoudi, Jerome Besse, Pierre Launay, Alexandre Passioukov, Eric Chetaille, Gilles Favre, Fabien Maldonado, Francisco Cruzalegui, Olivier Delfour, Julien Mazières, Vera Pancaldi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundLung cancer is the leading cause of cancer death worldwide, with poor survival despite recent therapeutic advances. A better understanding of the complexity of the tumor microenvironment is needed to improve patients’ outcome.MethodsWe ap
Externí odkaz:
https://doaj.org/article/714cfc5b4e3645af891ea976e7087685
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Cell deconvolution is the estimation of cell type fractions and cell type-specific gene expression from mixed data. An unmet challenge in cell deconvolution is the scarcity of realistic training data and the domain shift often observed in sy
Externí odkaz:
https://doaj.org/article/f65729ae982f492e93201a913c5510b2
Autor:
Renhui Guan, You Zuo, Qinglong Du, Aijing Zhang, Yijian Wu, Jianguo Zheng, Tongrui Shi, Lin Wang, Hui Wang, Nengwang Yu
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32294- (2024)
Background: This study introduces a novel prognostic tool, the Disulfidoptosis-Related lncRNA Index (DRLI), integrating the molecular signatures of disulfidoptosis and long non-coding RNAs (lncRNAs) with the cellular heterogeneity of the tumor microe
Externí odkaz:
https://doaj.org/article/6e7d8b662d7e4bcd999a881e3e465743
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4520 (2024)
The significant heterogeneity of Wilms’ tumors between different patients is thought to arise from genetic and epigenetic distortions that occur during various stages of fetal kidney development in a way that is poorly understood. To address this,
Externí odkaz:
https://doaj.org/article/19d6f6750c574c47bb76e40d4a803f8c
Publikováno v:
Epigenetics, Vol 17, Iss 8, Pp 882-893 (2022)
Flow cytometry is a classical approach used to define cell types in peripheral blood. While DNA methylation signatures have been extensively employed in recent years as an alternative to flow cytometry to define cell populations in peripheral blood,
Externí odkaz:
https://doaj.org/article/2363cfae9f64496198acb7ef1fe2c5f1
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Objectives: This study aimed to explore cell type level expression quantitative trait loci (eQTL) in adenocarcinoma at the gastroesophageal junction (ACGEJ) and identify susceptibility and prognosis markers.Methods: Whole-genome sequencing (WGS) was
Externí odkaz:
https://doaj.org/article/0445ae0a0f0d402dbf2c7dd6f0f476f6
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPredicting which preschool children with recurrent wheezing (RW) will develop school-age asthma (SA) is difficult, highlighting the critical need to clarify the pathogenesis of RW and the mechanistic relationship between RW and SA. Despite
Externí odkaz:
https://doaj.org/article/4cdc59658e4246899fa2fc0e5180c21c
Publikováno v:
Cells, Vol 12, Iss 8, p 1168 (2023)
Down syndrome (DS) is a genetic disorder caused by an extra copy of chromosome 21 that presents developmental dysfunction and intellectual disability. To better understand the cellular changes associated with DS, we investigated the cell composition
Externí odkaz:
https://doaj.org/article/b1ac8b5b24b641e89090823fd54e96e2
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