Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Autor: Millan, Cinthia R., Acosta-Reyes, Francisco J., Lagartera, Laura, Ebiloma, Godwin U., Lemgruber Soares, Leandro, Nué Martinez, J. Jonathan, Saperas, Núria, Dardonville, Christophe, De Koning, Harry P., Campos, J. Lourdes

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Digital.CSIC. Repositorio Institucional del CSIC
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Recercat. Dipósit de la Recerca de Catalunya

Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of drugs interacting with AT-rich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a4b97b0255dc6a7981b3a2ccd7466326
https://hdl.handle.net/2117/107671