Zobrazeno 1 - 10
of 1 252
pro vyhledávání: '"cell autonomous"'
Autor:
Ofra Novoplansky, Sankar Jagadeeshan, Manu Prasad, Ksenia M. Yegodayev, Divyasree Marripati, Raghda Abu Shareb, Yariv Greenshpan, Sooraj Mathukkada, Talal Ben-Lulu, Baisali Bhattacharya, Angel Porgador, Dexin Kong, Johannes Brägelmann, J. Silvio Gutkind, Moshe Elkabets
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-23 (2024)
Abstract Background Basket clinical trials targeting the KRASG12C-mutation in solid tumors have shown initial promise, including in orphan KRASG12C head and neck cancer (HNC). However, development of resistance to KRASG12C-mutant-specific inhibitors
Externí odkaz:
https://doaj.org/article/c4597987045c4368ad8d1ce46434bbc8
Publikováno v:
Healthcare in Low-resource Settings (2024)
Considering the significant impact of oncopathology on global morbidity and mortality, as well as changes in its prevalence and typology, research into the molecular-genetic mechanisms of oncogenesis and metastasis, particularly the role of nucleic a
Externí odkaz:
https://doaj.org/article/a3f4b394f58745d5ba8691ccac53e10a
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Amyotrophic lateral sclerosis (ALS) consists of a group of adult-onset fatal and incurable neurodegenerative disorders characterized by the progressive death of motor neurons (MNs) throughout the central nervous system (CNS). At first, ALS was consid
Externí odkaz:
https://doaj.org/article/64892792f71349959e74551959071cf8
Akademický článek
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Autor:
Gabriel Otero, Carmen Bolatto, Eugenia Isasi, Sofía Cerri, Paola Rodríguez, Daniela Boragno, Marta Marco, Cristina Parada, Matías Stancov, María Noel Cuitinho, Silvia Olivera-Bravo
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30360- (2024)
In amyotrophic lateral sclerosis (ALS), astrocytes are considered key players in some non-cell non-neuronal autonomous mechanisms that underlie motor neuron death. However, it is unknown how much of these deleterious features were permanently acquire
Externí odkaz:
https://doaj.org/article/648ccc7ad9d5405db8a32658f34bc2ca
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 289 (2024)
Today, neurodegenerative disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions of people worldwide, and as the average human lifespan increases, si
Externí odkaz:
https://doaj.org/article/43f14399fcf94854877ed2fe9e81df01
Autor:
David E. Cohn, Aisling Forder, Erin A. Marshall, Emily A. Vucic, Greg L. Stewart, Kouther Noureddine, William W. Lockwood, Calum E. MacAulay, Martial Guillaud, Wan L. Lam
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The growth and metastasis of solid tumours is known to be facilitated by the tumour microenvironment (TME), which is composed of a highly diverse collection of cell types that interact and communicate with one another extensively. Many of these inter
Externí odkaz:
https://doaj.org/article/6eeb70efdf25415aa30135a285879a32
Autor:
Karsten Meier, Lana H. Jachmann, Gözde Türköz, Mohammed Rizwan Babu Sait, Lucía Pérez, Oliver Kepp, Raphael H. Valdivia, Guido Kroemer, Barbara S. Sixt
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT The obligate intracellular bacterium Chlamydia trachomatis inserts a family of inclusion membrane (Inc) proteins into the membrane of its vacuole (the inclusion). The Inc CpoS is a critical suppressor of host cellular immune surveillance, bu
Externí odkaz:
https://doaj.org/article/c174e539b37e4bccb7df8b1155ca3c90
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Ring finger protein 213 (RNF213) is a large E3 ubiquitin ligase with a molecular weight of 591 kDa that is associated with moyamoya disease, a rare cerebrovascular disease. It is located in the cytosol and perinuclear space. Missense mutations in thi
Externí odkaz:
https://doaj.org/article/3801c972024b4f8d852a27b91a561832
Autor:
Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Brigitte van Zundert
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FT
Externí odkaz:
https://doaj.org/article/70b04753b9844b6f898175dad9993d01