Zobrazeno 1 - 10
of 1 815
pro vyhledávání: '"cecal ligation and puncture"'
Publikováno v:
Microbiology Research, Vol 15, Iss 3, Pp 1939-1956 (2024)
Sepsis is characterized by multiple organ dysfunction, which is now accepted to be due to oxidative damage. The lung is the first organ exposed to this damage, and its injury is one of the leading causes of death. Therefore, many pharmacological stra
Externí odkaz:
https://doaj.org/article/5da9577155604635b84c4ac9613c49d8
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Background Infusion of exogenous catecholamines (i.e., norepinephrine [NE] and dobutamine) is a recommended treatment for septic shock with myocardial dysfunction. However, sustained catecholamine infusion is linked to cardiac toxicity and i
Externí odkaz:
https://doaj.org/article/6d1b95c6c424433da2b125654cc89ac5
Autor:
Mustafa Güler, Ayhan Tanyeli, Ersen Eraslan, Özgür Çelebi, Demet Çelebi, Selim Çomakli, Emir Yurdgülü, Yasin Bayir
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 5, Pp 567-576 (2024)
Objective(s): Sepsis poses a significant threat to human life, rendering it a burdensome medical disease. Despite significant advancements, the current state of medical science still lacks a viable and efficacious cure. Costunolide (COST) is a multif
Externí odkaz:
https://doaj.org/article/7661d990d81642babc4ced051ead6493
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117359- (2024)
Sepsis, a frequently fatal condition, emerges from an exaggerated inflammatory response to infection, resulting in multi-organ dysfunction and alarmingly high mortality rates. Despite the urgent need for effective treatments, current therapeutic opti
Externí odkaz:
https://doaj.org/article/1a613cc7de214a7eb608fc7bc0655600
Autor:
Mabel N. Abraham, Ana Nedeljkovic-Kurepa, Tiago D. Fernandes, Omar Yaipen, Mariana R. Brewer, Daniel E. Leisman, Matthew D. Taylor, Clifford S. Deutschman
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024)
Abstract Background The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory reflex. Treatment with th
Externí odkaz:
https://doaj.org/article/1f6c39bde017455f943b50c9d73ef8c5
Publikováno v:
Open Chemistry, Vol 21, Iss 1, Pp 1308-16 (2023)
Sepsis is a common and deadly syndrome that despite all the progress in its control, the death rate caused by it is high. Sepsis is a serious problem that needs immediate attention and treatment. This infection, especially if it is caused by bacteria
Externí odkaz:
https://doaj.org/article/d4cae7c0e5ea4cd6835c9903b25d23b9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIndividual T cell responses vary significantly based on the microenvironment present at the time of immune response and on prior induced T cell memory. While the cecal ligation and puncture (CLP) model is the most commonly used murine sepsi
Externí odkaz:
https://doaj.org/article/02cd320690e34be9a06ede34ef7de0da
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26836- (2024)
Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive technique to quantify neurometabolic compounds in the living brain. We used 1H-MRS to evaluate the brain metabolites in a rat model of Sepsis-associated encephalopathy (SAE) est
Externí odkaz:
https://doaj.org/article/8aaea94937bb4eaaa5fd83f2639537cf
Autor:
Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-9 (2023)
Abstract Background Sepsis is characterized as an insulin resistant state. However, the effects of sepsis on insulin’s signal transduction pathway are unknown. The molecular activity driving insulin signaling is controlled by tyrosine phosphorylati
Externí odkaz:
https://doaj.org/article/918aea2b23df48e4a6b5643377a11c98
Lipid Fraction from Agaricus brasiliensis as a Potential Therapeutic Agent for Lethal Sepsis in Mice
Autor:
Kely Campos Navegantes Lima, Silvia Leticia de França Gaspar, Ana Ligia de Brito Oliveira, Sávio Monteiro dos Santos, Lucas Benedito Gonçalves Quadros, Juliana Pinheiro de Oliveira, Rayane Caroline dos Santos Pereira, Alexandre Guilherme da Silva Dias, Lucas da Silva Gato, Leonardo Yuji Nihira Alencar, Alanna Lorena Pimentel dos Santos, Gilson Pires Dorneles, Pedro Roosevelt Torres Romão, Herta Stutz, Vanessa Sovrani, Marta Chagas Monteiro
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 927 (2024)
Sepsis is a potentially fatal clinical condition that results from an immune imbalance in the host during an infection. It presents systemic alterations due to excessive activation of pro-inflammatory mediators that contribute to inflammation, format
Externí odkaz:
https://doaj.org/article/13f77260766942c482df77d067868b8f