Zobrazeno 1 - 10
of 581
pro vyhledávání: '"cdc7"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractCell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for
Externí odkaz:
https://doaj.org/article/a9474a61b420473c8be3cc0a61492459
Autor:
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 369-385 (2024)
The F‐box and WD repeat domain containing 7 (FBXW7) tumour suppressor gene encodes a substrate‐recognition subunit of Skp, cullin, F‐box (SCF)‐containing complexes. The tumour‐suppressive role of FBXW7 is ascribed to its ability to drive ub
Externí odkaz:
https://doaj.org/article/394126b61bef4541813ab49cbc06b55c
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 893-896 (2024)
Externí odkaz:
https://doaj.org/article/2469c3e0fab242d9ac956b726c2fd5e0
Autor:
Zhiying You, Hisao Masai
Publikováno v:
Biology, Vol 13, Iss 8, p 629 (2024)
In this review, we summarize the processes of the assembly of multi-protein replisomes at the origins of replication. Replication licensing, the loading of inactive minichromosome maintenance double hexamers (dhMCM2-7) during the G1 phase, is followe
Externí odkaz:
https://doaj.org/article/6edabcb6f52543b6800ba6884e04339e
Autor:
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Publikováno v:
Translational Oncology, Vol 39, Iss , Pp 101825- (2024)
Background: The enhancement of DNA damage repair is one of the important mechanisms of platinum resistance. Protein cell division cycle 7 (CDC7) is a conserved serine/threonine kinase that plays important roles in the initiation of DNA replication an
Externí odkaz:
https://doaj.org/article/2724c07db28e42c0b14998927c18a08b
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Hepatocellular carcinoma (HCC) remains one of the most common and lethal malignancies worldwide. Although DBF4-dependent kinase (DDK) complex composed of CDC7 kinase and its regulatory subunit DBF4 has been shown to be overexpress
Externí odkaz:
https://doaj.org/article/96d25cd384734ee6b8144880a6294b90
Publikováno v:
BMC Genetics, Vol 21, Iss S1, Pp 1-10 (2020)
Abstract Background Genome-wide association studies have identified the CDC7-TGFBR3 intergenic region on chromosome 1 to be strongly associated with optic disc area size. The mechanism of its function remained unclear until new data on eQTL markers e
Externí odkaz:
https://doaj.org/article/50cb62240864492c9cf41ccc7a2f3dbd
Autor:
Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard Baker, Munira A. Basrai
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2057-2068 (2020)
The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN
Externí odkaz:
https://doaj.org/article/18406182fbf848b19238234c13a0f3b1
Autor:
Gérard Vergoten, Christian Bailly
Publikováno v:
European Journal of Biological Research, Vol 11, Iss 4 (2021)
Drugs targeting the cell division cycle kinase 7 (Cdc7) are actively searched for the treatment of different pathologies such as amyotrophic lateral sclerosis and cancer. Cdc7 interacts with multiple protein partners, including protein Dbf4 to form t
Externí odkaz:
https://doaj.org/article/a6b8c17605cd486fbb6ded868152fd01
Autor:
María J. Cabello-Lobato, Cristina González-Garrido, María I. Cano-Linares, Ronald P. Wong, Aurora Yáñez-Vílchez, Macarena Morillo-Huesca, Juan M. Roldán-Romero, Marta Vicioso, Román González-Prieto, Helle D. Ulrich, Félix Prado
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109440- (2021)
Summary: The minichromosome maintenance (MCM) helicase physically interacts with the recombination proteins Rad51 and Rad52 from yeast to human cells. We show, in Saccharomyces cerevisiae, that these interactions occur within a nuclease-insoluble sca
Externí odkaz:
https://doaj.org/article/fc16006ac8644cb681297f621893f991