Zobrazeno 1 - 10
of 3 185
pro vyhledávání: '"cd73"'
Autor:
Hu Guo, Zhongyang Lv, Maochun Wang, Weitong Li, Ya Xie, Zizheng Liu, Fufei Chen, Ruiyang Jiang, Yuan Liu, Rui Wu, Jiawei Li, Ziying Sun, Guihua Tan, Dongquan Shi
Publikováno v:
Journal of Orthopaedic Translation, Vol 49, Iss , Pp 96-106 (2024)
Background: Osteoarthritis (OA) is the most common degenerative joint disease, with articular cartilage degeneration as primary manifestation. Intra-articular injection of exogenous liposomal adenosine in mice knee has been shown to alleviate OA prog
Externí odkaz:
https://doaj.org/article/0a7850d3dd9e4e9ea1aafc280e3ebe96
Autor:
Kyung-Ho Jung, Mina Kim, Hye Jin Jung, Hyun Jung Koo, Jung-Lim Kim, Hyunjong Lee, Kyung-Han Lee
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract CD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy. Immune response may therefore be improved by
Externí odkaz:
https://doaj.org/article/fdcbb2eca6e449df9bb4d885e1e5ca64
Autor:
Jianhao Zhan, Le Huang, Liyan Niu, Wenhui Lu, Chengpeng Sun, Shanshan Liu, Zijun Ding, Enliang Li
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract CD73, a cell surface-bound nucleotidase, serves as a crucial metabolic and immune checkpoint. Several studies have shown that CD73 is widely expressed on immune cells and plays a critical role in immune escape, cell adhesion and migration as
Externí odkaz:
https://doaj.org/article/83a99b15405240b2a21ea2d12b54b4f6
Autor:
Dan Liu, Jingjing Zhao, Ling Li, Jie Wang, Chao Wang, Yudong Wu, Yucun Huang, Dongming Xing, Wujun Chen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD73, an important metabolic and immune escape-promoting gene, catalyzes the hydrolysis of adenosine monophosphate (AMP) to adenosine (ADO). AMP has anti-inflammatory and vascular relaxant properties, while ADO has a strong immunosuppressive effect,
Externí odkaz:
https://doaj.org/article/b7e929fbe31c49edb7298a7289c90d84
Autor:
Marius Witt, Leticia Oliveira-Ferrer, Friedrich Koch-Nolte, Stephan Menzel, Louisa Hell, Tabea Sturmheit, Elisa Seubert, Pauline Weimer, Yi Ding, Minyue Qi, Barbara Schmalfeldt, Carsten Bokemeyer, Walter Fiedler, Jasmin Wellbrock, Franziska Brauneck
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Immune exhaustion is a hallmark of ovarian cancer. Using multiparametric flow cytometry, the study aimed to analyze protein expression of novel immunological targets on CD3+ T cells isolated from the peripheral blood (n = 20), malignant ascites (n =
Externí odkaz:
https://doaj.org/article/1bffabab673f4ad09e4c5725088b169b
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40329- (2024)
Background: CD73 is adenosine generation molecule, which is involved in the immune regulation. However, the roles of CD73 in the tumor microenvironment remain unknown. Methods: CD73 expression levels in pan-cancers were analyzed, based on The Cancer
Externí odkaz:
https://doaj.org/article/cdef2feef03946e7b309ede9abf43e75
Autor:
Paweł Kamil Serafin, Marta Popęda, Kamila Bulak, Agata Zwara, Barbara Galikowska-Bogut, Anna Przychodzka, Adriana Mika, Tomasz Śledziński, Marcin Stanisławowski, Kamila Jendernalik, Marika Bolcewicz, Wiktoria Laprus, Grzegorz Stasiłojć, Rafał Sądej, Anna Żaczek, Leszek Kalinowski, Patrycja Koszałka
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102035- (2024)
Objective: CD73 (ecto-5′-nucleotidase, NT5E), a cell-surface enzyme converting 5′-AMP to adenosine, is crucial for cancer progression. However, its role in the tumorigenesis process remains mostly obscure. We aimed to demonstrate CD73's role in b
Externí odkaz:
https://doaj.org/article/b3615b3f61fb402c840c23ea50ec3ddf
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 89-101 (2024)
Introduction: Immunomodulation is the predominant mechanism via which Mesenchymal stromal cells (MSCs) mediate their therapeutic benefits. However, inconsistent success in numerous clinical trials warrants a better understating of the molecular mecha
Externí odkaz:
https://doaj.org/article/a5462a71fc37428fa585a1f058929555
Autor:
Yanan Duan, Xiteng Chen, Hui Shao, Yongtao Li, Zhihui Zhang, Huan Li, Chuan Zhao, Hong Xiao, Jiawei Wang, Xiaomin Zhang
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Background Autoimmune uveitis is an inflammatory disease triggered by an aberrant immune response. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) are emerging as potential therapeutic agents for this condition. CD73, a
Externí odkaz:
https://doaj.org/article/08962d62a53048b3be50f9a569f15383
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