Zobrazeno 1 - 10
of 3 071
pro vyhledávání: '"cd33"'
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by progressive cognitive decline. Genetic factors have been implicated in disease susceptibility as its etiology remains multifactorial. The CD33 and the HLA-DRB1 gene
Externí odkaz:
https://doaj.org/article/ab8d5a4ec84a4e73b1681488b750db01
Autor:
Salvatore Fiorenza, Sheryl Y.T. Lim, George S. Laszlo, Erik L. Kimble, Tinh-Doan Phi, Margaret C. Lunn-Halbert, Delaney R. Kirchmeier, Jenny Huo, Hans-Peter Kiem, Cameron J. Turtle, Roland B. Walter
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200854- (2024)
Current CD33-targeted immunotherapies typically recognize the membrane-distal V-set domain of CD33. Here, we show that decreasing the distance between T cell and leukemia cell membrane increases the efficacy of CD33 chimeric antigen receptor (CAR) T
Externí odkaz:
https://doaj.org/article/baa603e202b243ff9dc78a34c841b8f3
Autor:
Ghazaleh Eskandari-Sedighi, Madeline Crichton, Sameera Zia, Erik Gomez-Cardona, Leonardo M. Cortez, Zain H. Patel, Kei Takahashi-Yamashiro, Chris D. St. Laurent, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew S. Macauley
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-27 (2024)
Abstract Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility
Externí odkaz:
https://doaj.org/article/e2bd71e630ca42e2903e16f780fc40b0
Autor:
Alessandro Laganà, Matteo Totaro, Maria Laura Bisegna, Loredana Elia, Stefania Intoppa, marco Beldinanzi, Mabel Matarazzo, Mariangela di Trani, Alessandro Costa, Raffaele Maglione, Biancamaria Mandelli, Sabina Chiaretti, Maurizio Martelli, Maria Stefania De Propris
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 16, Iss 1 (2024)
Background: B-lineage acute lymphoblastic leukemias (B-ALL) harboring the t(9;22)(q34;q11)/BCR::ABL1rearrangement, represent a category with previously dismal prognosis whose management and outcome dramatically changed thanks to the use of tyrosine k
Externí odkaz:
https://doaj.org/article/e29c4b9f93a64e38ba922c03229d13d1
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 264-269 (2024)
Introduction: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a rare subtype of T-cell leukemia that phenotypically expresses mature T-cell markers and immature myeloid markers such as CD33. Gemtuzumab ozogamicin (GO) is a novel agen
Externí odkaz:
https://doaj.org/article/e4a877c7ac114cfe989d3581610af225
Publikováno v:
Experimental Gerontology, Vol 187, Iss , Pp 112371- (2024)
Background: Increasing evidence has shown a link between immune cells and Alzheimer's disease (AD). Comprehensive two-sample Mendelian randomization (MR) analysis was performed to determine the causal association between 731 immune cell signatures an
Externí odkaz:
https://doaj.org/article/d5d67f76632b40e5bfa569d4dfc4ba1c
Autor:
Anggraini Iriani, Andhika Rachman, Rahayuningsih D. Setiabudy, Siti B. Kresno, Aru W. Sudoyo, Mansyur Arief, Alida R. Harahap, Marsya Kaila Fatina
Publikováno v:
BMC Molecular and Cell Biology, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Background Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established role in promoting ap
Externí odkaz:
https://doaj.org/article/9d13e52cee274f6ca42ff0eddb4e4fa0
Autor:
V. P. Timganova, K. Yu. Shardina, M. S. Bochkova, S. V. Uzhviyuk, D. I. Usanina, S. A. Zamorina
Publikováno v:
Медицинская иммунология, Vol 25, Iss 3, Pp 513-520 (2023)
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population that primarily suppress T lymphocytes in healthy pregnancies and pathologies. MDSCs are one of the key regulators of immune responses. Finding ways to control them is import
Externí odkaz:
https://doaj.org/article/13b45f1f6bbe4fd482b7708913503380
Autor:
Justin C. Boucher, Bishwas Shrestha, Paresh Vishwasrao, Mark Leick, Estelle V. Cervantes, Tayyebb Ghafoor, Kayla Reid, Kristen Spitler, Bin Yu, Brian C. Betts, Jose A. Guevara-Patino, Marcela V. Maus, Marco L. Davila
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100751- (2023)
CD33 and CD123 are expressed on the surface of human acute myeloid leukemia blasts and other noncancerous tissues such as hematopoietic stem cells. On-target off-tumor toxicities may limit chimeric antigen receptor T cell therapies that target both C
Externí odkaz:
https://doaj.org/article/950a3b2659db497d9c16853df8bab008
Autor:
Nicholas E. Petty, Stefan Radtke, Emily Fields, Olivier Humbert, Mallory J. Llewellyn, George S. Laszlo, Haiying Zhu, Keith R. Jerome, Roland B. Walter, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101121- (2023)
Current immunotherapeutic targets are often shared between neoplastic and normal hematopoietic stem and progenitor cells (HSPCs), leading to unwanted on-target, off-tumor toxicities. Deletion or modification of such targets to protect normal HSPCs is
Externí odkaz:
https://doaj.org/article/bbf076d5311d4ffc9cd892e144be7ab2