Zobrazeno 1 - 10
of 886
pro vyhledávání: '"cd123"'
Publikováno v:
陆军军医大学学报, Vol 46, Iss 4, Pp 347-351 (2024)
Objective To preliminarily explore the efficacy of chimeric antigen receptor T cells (CAR-T) targeting CD123 in the treatment of acute myeloid leukemia (AML) and the role of dasatinib in the treatment of CD123 targeting CAR-T induced side effects. Me
Externí odkaz:
https://doaj.org/article/80120cc6dc9542fab561a3a85af786e1
Autor:
Naveen Pemmaraju, Branko Cuglievan, Joseph Lasky, Albert Kheradpour, Nobuko Hijiya, Anthony S. Stein, Soheil Meshinchi, Craig A. Mullen, Emanuele Angelucci, Luciana Vinti, Tariq I. Mughal, Anna B. Pawlowska
Publikováno v:
eJHaem, Vol 5, Iss 1, Pp 61-69 (2024)
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) predominantly occurs in adults ≥60 years old; 10–20% of cases are pediatric or adolescent/young adult (AYA) patients. Tagraxofusp (TAG, Elzonris®) is the only approved treatment for B
Externí odkaz:
https://doaj.org/article/f0c19f1aedd446e39c2ceaabeb4efd0f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical orchestrator of inflammation in a wide array of diseases. Depending on
Externí odkaz:
https://doaj.org/article/b12d96d709a643b8b05f811aed1fdf59
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
The inflammatory response to viral infection is an important component of the antiviral response, a process that involves the activation and proliferation of CD8+ T, CD4+ T, and dendritic cells; thus, viral infection disrupts the immune homeostasis o
Externí odkaz:
https://doaj.org/article/26073b116fe64cd4809a1705b1a6e87f
Akademický článek
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Autor:
Justin C. Boucher, Bishwas Shrestha, Paresh Vishwasrao, Mark Leick, Estelle V. Cervantes, Tayyebb Ghafoor, Kayla Reid, Kristen Spitler, Bin Yu, Brian C. Betts, Jose A. Guevara-Patino, Marcela V. Maus, Marco L. Davila
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100751- (2023)
CD33 and CD123 are expressed on the surface of human acute myeloid leukemia blasts and other noncancerous tissues such as hematopoietic stem cells. On-target off-tumor toxicities may limit chimeric antigen receptor T cell therapies that target both C
Externí odkaz:
https://doaj.org/article/950a3b2659db497d9c16853df8bab008
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTChimeric antigen receptor (CAR)-T cells have not made significant progress in the treatment of acute myeloid leukemia (AML) in earlyclinical studies. This lack of progress could be attributed in part to the immunosuppressive microenvironment
Externí odkaz:
https://doaj.org/article/ce21bdd2d62c4e0f8d350aaa3c4c612f
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Dermatology Reports (2023)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic neoplasm (less than 1% of primary cutaneous lymphomas and acute leukemia) with a highly aggressive clinical course and frequent skin, bone marrow and central nervous system (C
Externí odkaz:
https://doaj.org/article/3d7b0c9c8dc44e5ab528a7340658d10a
Autor:
Danni Xie, Xin Jin, Rui Sun, Meng Zhang, Wenyi Lu, Xinping Cao, Ruiting Guo, Yi Zhang, Mingfeng Zhao
Publikováno v:
Translational Oncology, Vol 34, Iss , Pp 101695- (2023)
Purpose: Acute myeloid leukemia (AML) is a highly heterogeneous neoplastic disease with a poor prognosis that relapses even after its treatment with chimeric antigen receptor (CAR)-T cells targeting a single antigen. CD123 and CLL1 are expressed in m
Externí odkaz:
https://doaj.org/article/fb0b49f90a6149baba9c49e8e3014e83