Zobrazeno 1 - 10
of 3 089
pro vyhledávání: '"ccrcc"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Immunotherapy has emerged as a vital component in the contemporary landscape of cancer treatment. Recent studies have indicated that CEP55 plays an oncogenic role; however, its specific mechanisms in promoting tumor proliferation and its pot
Externí odkaz:
https://doaj.org/article/452b6cae713c46a299a151bf4057d546
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background The microenvironment of clear cell renal cell carcinoma (ccRCC) is characterized by hypoxia and increased lactate production. However, the impact of hypoxia and lactate metabolism on ccRCC remains incompletely understood. In this
Externí odkaz:
https://doaj.org/article/fb08ee2acafb422191a27533fc1a8bff
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Increasing evidence highlights the important role of ubiquitination in cancer. The objective of our study is to establish a reliable marker for predicting clinical outcomes and treatment responses in patients with clear cell renal cell carci
Externí odkaz:
https://doaj.org/article/06c10d14541a4be5ba5190b5081eb52f
Autor:
Yongliang Lu, Weihao Chen, Yundong Xuan, Xiubin Li, Shengpan Wu, Hanfeng Wang, Tao Guo, Chenfeng Wang, Shuo Tian, Huaikang Li, Dong Lai, Wenlei Zhao, Xing Huang, Xupeng Zhao, Baojun Wang, Xu Zhang, Hongzhao Li, Yan Huang, Xin Ma
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Cancer cells encounter unavoidable stress during tumor growth. The stress-induced transcription factor, activating transcription factor 4 (ATF4), has been reported to upregulate various adaptive genes involved in salvage pathways to alleviat
Externí odkaz:
https://doaj.org/article/b37adf6177d34bb09b6a9d976e38a2c2
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Introduction Although there are some established prognostic evaluation models for clear cell renal cell carcinoma (ccRCC), more robust postoperative prognostic evaluation model is urgently needed. Our study intends to explore new clinical an
Externí odkaz:
https://doaj.org/article/8f0486e6171e4ab789c6b45d80c04673
Autor:
Shuhui Chang, Yucong Wang, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan, Liang Chen
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-15 (2024)
Exonic circular RNAs (ecircRNAs) in animal cells are generated by backsplicing, and the biogenesis of ecircRNAs is regulated by an array of RNA binding proteins (RBPs). HNRNPD is a heterogeneous nuclear ribonucleoprotein family member with both cytop
Externí odkaz:
https://doaj.org/article/1a9dfde8bb574660bad67664f21eaaaf
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Numerous studies have shown that the Krüppel-like factors (KLFs) family of transcription factors regulate various eukaryotic physiological processes including the proliferation, differentiation, senescence, death, and carcinogenesis of anim
Externí odkaz:
https://doaj.org/article/321d0faf2d7b4396a7bc0518e6e3bf97
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network. Understanding the heterogene
Externí odkaz:
https://doaj.org/article/04dc806e60cc4bfba9b68ee04ce9a8ea
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract This study investigated the impact of novel copper ionophores on the prognosis of clear cell renal cell carcinoma (ccRCC) and the tumor microenvironment (TME). The differential expression of 10 cuproptosis and 40 TME-pathway-related genes we
Externí odkaz:
https://doaj.org/article/b33dffed9ece4342bc8d14c7f0dd7c2c
Autor:
Zhaoyang Zhu, Yigang Jin, Jing Zhou, Fei Chen, Minjie Chen, Zhaofeng Gao, Lingyu Hu, Jinyan Xuan, Xiaoping Li, Zhengwei Song, Xiao Guo
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract The advent of PD1/PD-L1 inhibitors has significantly transformed the therapeutic landscape for clear cell renal cell carcinoma (ccRCC). This review provides an in-depth analysis of the biological functions and regulatory mechanisms of PD1 an
Externí odkaz:
https://doaj.org/article/347493d7579240c190038a7b1eaf2a30