Zobrazeno 1 - 10
of 41
pro vyhledávání: '"cccDNA, covalently closed circular DNA"'
Autor:
Masaaki Shiina, Masatoshi Ishigami, Takanori Ito, Teiji Kuzuya, Asuka Kato, Norie Yamada, Takanobu Kato, Tetsuya Ishikawa, Masamichi Muramatsu, Mitsuhiro Fujishiro, Tomohisa Tanaka, Kohji Moriishi, Yoji Ishizu, Yoshiki Murakami, Hussein H. Aly, Hironori Nishitsuji, Kunitada Shimotohno, Asako Murayama, Takaji Wakita, Takashi Honda
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1583-1598 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1583-1598 (2021)
Background & Aims To provide an adequate treatment strategy for chronic hepatitis B, it is essential to know which patients are expected to have a good prognosis and which patients do not require therapeutic intervention. Previously, we identified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ffd0d58d93a8a01ec3dbbe756085ae
http://europepmc.org/articles/PMC8536788
http://europepmc.org/articles/PMC8536788
Publikováno v:
JHEP Reports, Vol 4, Iss 2, Pp 100398-(2022)
JHEP Reports
JHEP Reports
Summary: Insights into the immunopathogenesis of chronic HBV infections are fundamental in the quest for novel treatment approaches aimed at a functional cure. While much is known about the ineffective HBV-specific T-cell responses that characterise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d94254af9777a2d520ff3678645b2ff
http://www.sciencedirect.com/science/article/pii/S2589555921001749
http://www.sciencedirect.com/science/article/pii/S2589555921001749
Autor:
Rei Ishibashi, Motoyuki Otsuka, Eri Tanaka, Motoko Ohno, Mari Yamagami, Takahiro Kishikawa, Takahiro Seimiya, Kazuhiko Koike, Tatsunori Suzuki, Kazuma Sekiba
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 297-312 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Hepatitis B virus (HBV) infection is a major health concern worldwide. Although currently used nucleos(t)ide analogs efficiently inhibit viral replication, viral proteins transcribed from the episomal viral covalently closed circula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c7677e529575b879027fb0f0ac4368
https://doi.org/10.1016/j.jcmgh.2018.10.010
https://doi.org/10.1016/j.jcmgh.2018.10.010
Autor:
Tatyana G. Vishnyakova, Amy P. Patterson, Zhigang Chen, Alexander V. Bocharov, Irina N. Baranova, Thomas L. Eggerman
Publikováno v:
The Journal of Biological Chemistry
APOBEC3s are innate single-stranded DNA cytidine-to-uridine deaminases that catalyze mutations in both pathogen and human genomes with significant roles in human disease. However, how APOBEC3s mutate a single-stranded DNA that is available momentaril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b09003b9ebc1b1f0ff385c1873be55
https://pubmed.ncbi.nlm.nih.gov/34181944
https://pubmed.ncbi.nlm.nih.gov/34181944
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 4, Pp 100295-(2021)
JHEP Reports, Vol 3, Iss 4, Pp 100295-(2021)
Background & Aims Current standard-of-care suppresses HBV replication, but does not lead to a functional cure. Treatment aiming to cure chronic hepatitis B (CHB) is believed to require the induction of strong cellular immune responses, such as by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa6a662c3c140792ac90ba2679e0c6e
http://europepmc.org/articles/PMC8203848
http://europepmc.org/articles/PMC8203848
Autor:
Robert L. Kruse, Janming Xu, Francis P. Pankowicz, Nika Furey, Mercedes Barzi, Betty L. Slagle, Xavier Legras, Karl-Dimiter Bissig, Lan Liao, Beatrice Bissig-Choisat
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100252-(2021)
JHEP Reports, Vol 3, Iss 2, Pp 100252-(2021)
Background & Aims Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models. The HBV transgenic mouse model containing an integrated overlength 1.3-mer construct has yielded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0ab56ba4195822ba35411130527583
http://europepmc.org/articles/PMC7940981
http://europepmc.org/articles/PMC7940981
Autor:
David Shum, Seung Kew Yoon, Marc Peter Windisch, Soonju Park, Eva Zusinaite, Eunji Jo, Denis E. Kainov, Jaewon Yang, Pil Soo Sung, Alexander König
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 4, Pp 100296-(2021)
JHEP Reports, Vol 3, Iss 4, Pp 100296-(2021)
Background & Aims Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single experimental setup. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d39818aec9a96715b2a465ff2da762
https://hdl.handle.net/11250/3045132
https://hdl.handle.net/11250/3045132
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 1, Pp 100195-(2021)
JHEP Reports, Vol 3, Iss 1, Pp 100195-(2021)
Background & Aims Chronic HBV infection cannot be cured by current therapeutics owing to their limited ability to reduce covalently closed circular (ccc)DNA levels in the livers of infected individuals. Therefore, greater understanding of the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bfefc4b6b11b610f3e653d61c3e10c
http://europepmc.org/articles/PMC7771110
http://europepmc.org/articles/PMC7771110
Autor:
Ching-Lung Lai, Wai-Kay Seto, James Fung, Danny Ka-Ho Wong, Gerald Tsz-Yau Wong, Man-Fung Yuen
Publikováno v:
JHEP Reports
JHEP Reports, Vol 2, Iss 3, Pp-(2020)
JHEP Reports, Vol 2, Iss 3, Pp-(2020)
Background & Aims Nucleos(t)ide analogues (NUCs) effectively suppress serum HBV DNA. Previously, we have identified 21 patients with undetectable covalently closed circular DNA (cccDNA) upon long-term NUC therapy. This study investigated the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f361dc2837c09edd57e5e10b81db8900
http://europepmc.org/articles/PMC7242874
http://europepmc.org/articles/PMC7242874
Autor:
Héloïse Auclair, Julie Lucifora, François-Loïc Cosset, Caroline Pons, Émilie Charles, Florentin Pastor, Anna Salvetti, Floriane Fusil, David Durantel, Michel Rivoire
Publikováno v:
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (5), pp.100330. ⟨10.1016/j.jhepr.2021.100330⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 5, Pp 100330-(2021)
JHEP Reports Innovation in Hepatology, 2021, 3 (5), pp.100330. ⟨10.1016/j.jhepr.2021.100330⟩
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (5), pp.100330. ⟨10.1016/j.jhepr.2021.100330⟩
JHEP Reports
JHEP Reports, Vol 3, Iss 5, Pp 100330-(2021)
JHEP Reports Innovation in Hepatology, 2021, 3 (5), pp.100330. ⟨10.1016/j.jhepr.2021.100330⟩
Background & Aims HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis. Both HBx and HBc (core) viral proteins associate with cccDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa92c81cb7c1546d3f56a1e2f73765e4
https://doi.org/10.1016/j.jhepr.2021.100330
https://doi.org/10.1016/j.jhepr.2021.100330