Zobrazeno 1 - 10
of 1 824
pro vyhledávání: '"cb2 receptor"'
Autor:
Gemma Navarro, Marc Gómez-Autet, Paula Morales, Joan Biel Rebassa, Claudia Llinas del Torrent, Nadine Jagerovic, Leonardo Pardo, Rafael Franco
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107363- (2024)
G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by ligand binding. Here, we show that a homobivalent ligand
Externí odkaz:
https://doaj.org/article/0e0661cb783749e1bee2b5a8648b5e8e
Publikováno v:
Cells, Vol 13, Iss 22, p 1875 (2024)
The endocannabinoid signalling system (ECS) plays a critical role from the very beginning of embryogenesis. Accordingly, the ECS is engaged early on in nervous system development, starting from neurulation, supported by the identification of ECS comp
Externí odkaz:
https://doaj.org/article/5c5dc6546e4443c6a205803237f9e305
Publikováno v:
Journal of Veterinary Research, Vol 67, Iss 4, Pp 611-618 (2023)
Mast cell tumours (MCTs) arise in the dermis and subcutaneous tissues in animals and humans and are one of the most common neoplasms of the skin in dogs. Cannabinoid type 2 receptor (CB2R), cyclin-dependent kinase inhibitor (p21) and matrix metallopr
Externí odkaz:
https://doaj.org/article/e15cf7e8e15e4c029aaf7a96a6ace2ac
Akademický článek
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Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1545 (2024)
The use of paclitaxel as a chemotherapeutic drug is limited by the development of dose-dependent paclitaxel-induced neuropathic pain (PINP). Recently, we observed that the combination of indomethacin plus minocycline (IPM) attenuates PINP in a mouse
Externí odkaz:
https://doaj.org/article/7d7a0d2b45cd4ff89a3a0b2dd4c67d76
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
Parkinson’s disease (PD) is featured by movement impairments, including tremors, bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor symptoms, such as cognitive impairments, dementia, and mental disorders. Previ
Externí odkaz:
https://doaj.org/article/01dcaedf3a2a478496d4387508866b9e
Akademický článek
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Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract The rapid structural evolution and emergence of novel synthetic cannabinoid receptor agonists (SCRAs) in the recreational market remains a key public health concern. Despite representing one of the largest classes of new psychoactive substan
Externí odkaz:
https://doaj.org/article/c919f35acb4c4ee1bfb8d1d5487d2cf5
Publikováno v:
Revista de Odontologia da UNESP, Vol 52 (2023)
Abstract Introduction Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammator
Externí odkaz:
https://doaj.org/article/b78936cef08641ada1662cf25f8eccb2
Autor:
Yanjing Zhu, Ruiqi Huang, Deheng Wang, Liqun Yu, Yuchen Liu, Runzhi Huang, Shuai Yin, Xiaolie He, Bairu Chen, Zhibo Liu, Liming Cheng, Rongrong Zhu
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 18, Iss 4, Pp 100835- (2023)
Alzheimer's disease (AD) is a typical neurodegenerative disease that leads to irreversible neuronal degeneration, and effective treatment remains elusive due to the unclear mechanism. We utilized biocompatible mesenchymal stem cell-derived extracellu
Externí odkaz:
https://doaj.org/article/a73c5be3777f46ad8fbff58fe7c98bba