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pro vyhledávání: '"cation loss - cell volume"'
Autor:
Gibson, John S, Rees, David C
Publikováno v:
Expert Opinion on Therapeutic Targets. 27:133-149
INTRODUCTION: In sickle cell disease (SCD), a single amino acid substitution at β6 of the hemoglobin (Hb) chain replaces glutamate with valine, forming HbS instead of the normal adult HbA. Loss of a negative charge, and the conformational change in