New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

Autor: Joana Moreira, Diana Ribeiro, Patrícia M. A. Silva, Nair Nazareth, Madalena Monteiro, Andreia Palmeira, Lucília Saraiva, Madalena Pinto, Hassan Bousbaa, Honorina Cidade

Publikováno v: Molecules, Vol 24, Iss 1, p 129 (2018)

The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7

Externí odkaz: https://doaj.org/article/6a25c5d6337b4b81915c314d6ab0fd1d

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation

Autor: Patrícia M. A. Silva, Hassan Bousbaa, Madalena Pinto, Honorina Cidade, Nair Nazareth, Andreia Palmeira, Madalena Monteiro, Joana Moreira, Lucília Saraiva, Diana Ribeiro

Publikováno v: Molecules
Molecules, Vol 24, Iss 1, p 129 (2018)
Volume 24
Issue 1

The antitumor activity of natural flavonoids has been exhaustively reported. Previously it has been demonstrated that prenylation of flavonoids allows the discovery of new compounds with improved antitumor activity through the activation of caspase-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a6aa735ad177db9c7f15f93615fa2e
https://doi.org/10.3390/molecules24010129

Caspases and cancer: Mechanisms of inactivation and new treatment modalities

Autor: Alex Philchenkov, Zavelevich, M., Kroczak, T. J., Los, M.

Publikováno v: Scopus-Elsevier

Elimination of superfluous or mutated somatic cells is provided by various mechanisms including apoptosis. Deregulation of apoptotic signaling pathways may contribute to oncogenesis. Aspartate specific cysteine proteases, termed caspases are the key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::45295c3a9d0e9f21dfd8b8aed5b67221
http://www.scopus.com/inward/record.url?eid=2-s2.0-3242806104&partnerID=MN8TOARS

New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.

Autor: Moreira J; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. joana.m26@hotmail.com.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. joana.m26@hotmail.com., Ribeiro D; CESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal. diana.ribeiro@cespu.pt., Silva PMA; CESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal. patricia.silva@cespu.pt., Nazareth N; LAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. naircampos@gmail.com., Monteiro M; LAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madsmonteiro@gmail.com., Palmeira A; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. andreiapalmeira@gmail.com.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. andreiapalmeira@gmail.com., Saraiva L; LAQV/REQUIMTE, Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. lucilia.saraiva@ff.up.pt., Pinto M; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. madalena@ff.up.pt.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. madalena@ff.up.pt., Bousbaa H; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. hassan.bousbaa@iucs.cespu.pt.; CESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal. hassan.bousbaa@iucs.cespu.pt., Cidade H; Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. hcidade@ff.up.pt.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal. hcidade@ff.up.pt.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2018 Dec 31; Vol. 24 (1). Date of Electronic Publication: 2018 Dec 31.