Zobrazeno 1 - 10
of 735
pro vyhledávání: '"caspase‐2"'
Autor:
Amaya Lopez-Pascual, Marc Cusachs, María Arechederra, Carmen Berasain, Matías A. Ávila, Maite G. Fernández-Barrena
Publikováno v:
Exploration of Digestive Diseases, Vol 1, Iss 2, Pp 80-96 (2022)
Caspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit functionally poorly defined member of the caspase fam
Externí odkaz:
https://doaj.org/article/d92e9ff5315d42238b0b96d2e9861c93
Publikováno v:
Biology, Vol 13, Iss 1, p 49 (2024)
Caspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in the field ab
Externí odkaz:
https://doaj.org/article/f99c1834d86744c4bd1606a11c010ee7
Autor:
Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C. Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E. Ehrnhoefer
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106126- (2023)
Intraneuronal aggregates of the microtubule binding protein Tau are a hallmark of different neurodegenerative diseases including Alzheimer's disease (AD). In these aggregates, Tau is modified by posttranslational modifications such as phosphorylation
Externí odkaz:
https://doaj.org/article/ff39934c4d48495f9ed3afb8322255d0
Autor:
Wei-Na Chai, Yi-Fan Wu, Zhi-Min Wu, Yan-Feng Xie, Quan-Hong Shi, Wei Dan, Yan Zhan, Jian-Jun Zhong, Wei Tang, Xiao-Chuan Sun, Li Jiang
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 1, Pp 163-169 (2022)
Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice. Whether Neat1 has protective or inhibitory effects on
Externí odkaz:
https://doaj.org/article/c58f5fe70b214e80868eabd0ebc51822
Publikováno v:
Korean Journal of Clinical Laboratory Science, Vol 53, Iss 2, Pp 158-164 (2021)
Hypertriglyceridemia is the main risk factor for atherosclerosis. It is reported that triglyceride (TG) induces macrophage cell death, and is involved in the formation of plaques and development of atherosclerosis. We previously reported that TG-in
Externí odkaz:
https://doaj.org/article/566b5cd936d947469472372359b49468
Autor:
Petar M Mitrasinovic
Publikováno v:
Acta Chimica Slovenica, Vol 67, Iss 3, Pp 876-884 (2020)
For a variety of biological and medical reasons, the ongoing development of humane caspase-2 inhibitors is of vital importance. Herein, a hybrid (Quantum Mechanics/Molecular Mechanics - QM/MM), two-layered molecular model is derived in order to under
Externí odkaz:
https://doaj.org/article/e0cceda422fa41bfa27144d908681faf
Akademický článek
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Autor:
Benjamin R. Smith, Kathryn M. Nelson, Lisa J. Kemper, Kailee Leinonen-Wright, Ashley Petersen, C. Dirk Keene, Karen H. Ashe
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Lewy body diseases are neurodegenerative disorders characterized by Lewy bodies in the brain. Lewy body dementia (LBD) refers to two forms of Lewy body disease: Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB). T
Externí odkaz:
https://doaj.org/article/5bbec8b209d9499085d162c8935f1a6c
Autor:
Peng Liu, Benjamin R. Smith, Eric S. Huang, Abhishek Mahesh, Jean Paul G. Vonsattel, Ashley J. Petersen, Rocio Gomez-Pastor, Karen H. Ashe
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Huntington’s disease (HD) is a progressive neurodegenerative disease. Involuntary movements, cognitive impairment and psychiatric disturbance are the major clinical manifestations, and gradual atrophy and selective neuronal loss in the str
Externí odkaz:
https://doaj.org/article/bfeaca9ab7f04f0397abd24da55d5320