Výsledky vyhledávání - "casein kinase 1 (CK1)"

Akademický článek

The protein kinase CK1: Inhibition, activation, and possible allosteric modulation

Autor: Yashoda Krishna Sunkari, Laurent Meijer, Marc Flajolet

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Protein kinases play a vital role in biology and deregulation of kinases is implicated in numerous diseases ranging from cancer to neurodegenerative diseases, making them a major target class for the pharmaceutical industry. However, the high degree

Externí odkaz: https://doaj.org/article/96df9329ac934c1c9b5378a916639675

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Akademický článek

Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells

Autor: Yumeng Zhang, Jiaqi Xu, Zhili Ren, Ya Meng, Weiwei Liu, Ligong Lu, Zhou Zhou, Guokai Chen

Publikováno v: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)

Abstract Background Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancreatic cell differentiat

Externí odkaz: https://doaj.org/article/65d5c27f95e4441eb09151f6f1941b40

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Akademický článek

Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch

Autor: Joel C. Francisco, David M. Virshup

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Biological systems operate in constant communication through shared components and feedback from changes in the environment. Casein kinase 1 (CK1) is a family of protein kinases that functions in diverse biological pathways and its regulation is begi

Externí odkaz: https://doaj.org/article/781a4c78cd8b4b838fb2f44a261184bc

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Akademický článek

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Autor: Ondrej Benek, Lukas Hroch, Laura Aitken, Frank Gunn-Moore, Lucie Vinklarova, Kamil Kuca, Daniel I. Perez, Concepcion Perez, Ana Martinez, Zdenek Fisar, Kamil Musilek

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 665-670 (2018)

Several neurodegenerative disorders including Alzheimer’s disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies. Recently

Externí odkaz: https://doaj.org/article/e6a3739db0ac4249892a19629268c016

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Akademický článek

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1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Autor: Concepción Pérez, Daniel I. Perez, Zdenek Fisar, Lukas Hroch, Ondrej Benek, Kamil Kuca, Frank J. Gunn-Moore, Kamil Musilek, Ana Martínez, Laura Aitken, Lucie Vinklarova

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 665-670 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
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Journal of Enzyme Inhibition and Medicinal Chemistry

6 p.-2 fig.-2 tab. Benek, O. et al.
Several neurodegenerative disorders including Alzheimer's disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165ba45be77aced7ee46436b66b4ee64
https://doi.org/10.1080/14756366.2018.1445736

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Building a complex for destruction

Autor: Felix van der Krift, Anton J. Venhuizen, Madelon M. Maurice

Publikováno v: Molecular Cell

Summary The Wnt/β-catenin pathway is a highly conserved, frequently mutated developmental and cancer pathway. Its output is defined mainly by β-catenin’s phosphorylation- and ubiquitylation-dependent proteasomal degradation, initiated by the mult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7d1c380857eb7c9c71795952c65094
https://pubmed.ncbi.nlm.nih.gov/34352208

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Nicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells

Autor: Ligong Lu, Zhili Ren, Weiwei Liu, Ya Meng, Zhou Zhou, Yumeng Zhang, Guokai Chen, Jiaqi Xu

Publikováno v: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2021)

Background Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancreatic cell differentiation from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88823fcda0a91bd79dd172bb8ed2287
https://doi.org/10.1186/s13287-021-02426-2

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