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pro vyhledávání: '"carrier-mediated transport"'
Autor:
Toshihiko Tashima
Publikováno v:
Future Pharmacology, Vol 4, Iss 3, Pp 479-493 (2024)
The membrane impermeability of a drug poses a significant challenge in drug research and development, preventing effective drug delivery to the target site. Specifically, the blood-brain barrier (BBB) presents a formidable obstacle to the delivery of
Externí odkaz:
https://doaj.org/article/257e6c886d204bab932c0bb4c790af5d
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2302 (2024)
The bloodstream and the central nervous system (CNS) are separated by the blood–brain barrier (BBB), an intricate network of blood vessels. Its main role is to regulate the environment within the brain. The primary obstacle for drugs to enter the C
Externí odkaz:
https://doaj.org/article/fd74146a4f4346b8abd71470761f9934
Autor:
Toshihiko Tashima
Publikováno v:
Future Pharmacology, Vol 3, Iss 4, Pp 742-762 (2023)
While it is true that pharmacotherapy has achieved desired health outcomes, significant unmet medical needs persist in the field of central nervous system (CNS) drugs, particularly for neurodegenerative diseases such as Alzheimer’s disease, as well
Externí odkaz:
https://doaj.org/article/158e53a0b2f244928a0568d056a7753c
Publikováno v:
Partial Differential Equations in Applied Mathematics, Vol 8, Iss , Pp 100594- (2023)
In this article, a carrier-mediated transport model is considered. The steady-state non-linear diffusion equations were solved by two effective and accessible analytical methods, Akbari-Ganji and the differential transform methods. Here, we present t
Externí odkaz:
https://doaj.org/article/922036969250419cb661ed093c0e0436
Autor:
Toshihiko Tashima
Publikováno v:
Antibodies, Vol 12, Iss 3, p 43 (2023)
Drug development for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease has challenging difficulties due to the pharmacokinetic impermeability based on the blood-brain barrier (BBB) as well as
Externí odkaz:
https://doaj.org/article/53f756a743ab47d1a44cc78f91a96a7e
Publikováno v:
View, Vol 3, Iss 1, Pp n/a-n/a (2022)
Abstract The blood–brain barrier (BBB) is a highly regulated and efficient barrier that controls the mass transfer between blood and brain, severely limits brain penetration of systemically administered therapeutics. During the onset and progressio
Externí odkaz:
https://doaj.org/article/885a187b392f43de8eff37cb3a76e182
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1392 (2022)
Paeonol is a naturally occurring phenolic agent that attenuates neurotoxicity in neurodegenerative diseases. We aimed to investigate the antioxidant and protective effects of paeonol and determine its transport mechanism in wild-type (WT; NSC-34/hSOD
Externí odkaz:
https://doaj.org/article/f79c1d4aa421454aa60ab939a4b4ae2f
Autor:
William M. Pardridge
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1283 (2022)
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914, that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood–brain barrier (BBB). Owing to restricted transport across t
Externí odkaz:
https://doaj.org/article/c6269489b0de40d684315bd8d3065bb8
Autor:
Gerardo León, Elisa Gómez, Beatriz Miguel, Asunción María Hidalgo, María Gómez, María Dolores Murcia, María Amelia Guzmán
Publikováno v:
Membranes, Vol 12, Iss 1, p 66 (2022)
Emulsion liquid membranes have been successfully used for the removal of different types of organic and inorganic pollutants by means of carrier-mediated transport mechanisms. However, the models that describe the kinetics and transport of such mecha
Externí odkaz:
https://doaj.org/article/6c1b50dfdd2a4cd09ad1f808ccee17f2
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