Zobrazeno 1 - 10
of 1 836
pro vyhledávání: '"cardiac fibroblast"'
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 7, Pp 832-840 (2024)
Objective(s): Slit guidance ligand 3 (SLIT3) has been identified as a potential therapeutic regulator against fibroblast activity and fibrillary collagen production in an autocrine manner. However, this research aims to investigate the potential role
Externí odkaz:
https://doaj.org/article/532d63f25b054662b67196e1964d033d
Publikováno v:
FEBS Open Bio, Vol 14, Iss 6, Pp 983-1000 (2024)
Myocardial infarction results in extensive cardiomyocyte apoptosis, leading to the formation of noncontractile scar tissue. Given the limited regenerative capacity of adult mammalian cardiomyocytes, direct reprogramming of cardiac fibroblasts (CFs) i
Externí odkaz:
https://doaj.org/article/30e4af0215e34f6b8b1455d19ecf909f
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34260- (2024)
Background: Endogenous sulfur dioxide (SO2) plays a crucial role in protecting heart from myocardial fibrosis by inhibiting the excessive growth of cardiac fibroblasts. This study aimed to investigate potential mechanisms by which SO2 suppressed myoc
Externí odkaz:
https://doaj.org/article/0a5bc996631d41de927957a300cd90d9
Autor:
Josephina J. H. M. Smits, Atze van der Pol, Marie José Goumans, Carlijn V. C. Bouten, Ignasi Jorba
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The dynamic nature of the extracellular matrix (ECM), particularly its stiffness, plays a pivotal role in cellular behavior, especially after myocardial infarction (MI), where cardiac fibroblasts (cFbs) are key in ECM remodeling. This study explores
Externí odkaz:
https://doaj.org/article/4bd0c4fb846e400587fcb09ea42e9ca1
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 4, Pp n/a-n/a (2024)
Abstract Background Severe myocarditis is often accompanied by cardiac fibrosis, but the underlying mechanism has not been fully elucidated. CXCL4 is a chemokine that has been reported to have pro‐inflammatory and profibrotic functions. The exact r
Externí odkaz:
https://doaj.org/article/491adfd6afa6403d8912d5f8f0154594
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cardiac fibrosis is a serious health problem because it is a common pathological change in almost all forms of cardiovascular diseases. Cardiac fibrosis is characterized by the transdifferentiation of cardiac fibroblasts (CFs) into cardiac myofibrobl
Externí odkaz:
https://doaj.org/article/a9dde22c0ea04995976f2b6e3bf2ce9d
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Inflammation and cardiac fibrosis are prevalent pathophysiologic conditions associated with hypertension, cardiac remodeling, and heart failure. Endoplasmic reticulum (ER) stress triggers the cells to activate unfolded protein responses (UPRs) and up
Externí odkaz:
https://doaj.org/article/a78b4a0eab2a4b05a07aedccfc0320b0
Autor:
Luke R. Perreault, Mark C. Daley, Matthew C. Watson, Sagar Rastogi, Ajith Jaiganesh, Elizabeth C. Porter, Breanna M. Duffy, Lauren D. Black
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Heart failure afflicts an estimated 6.5 million people in the United States, driven largely by incidents of coronary heart disease (CHD). CHD leads to heart failure due to the inability of adult myocardial tissue to regenerate after myocardial infarc
Externí odkaz:
https://doaj.org/article/f63786a426bc4831af35fd47940fef31
Publikováno v:
Journal of Physiological Sciences, Vol 73, Iss 1, Pp 1-11 (2023)
Abstract Intracellular calcium (Ca2+) signaling regulates many cellular functions, including cell proliferation and migration, in both normal cells and cancer cells. Store-operated Ca2+ entry (SOCE) is a major mechanism by which Ca2+ is imported from
Externí odkaz:
https://doaj.org/article/64fcde40fd514906bf2df1e75e30a656
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6004 (2024)
Cardiac fibrosis, a process characterized by excessive extracellular matrix (ECM) deposition, is a common pathological consequence of many cardiovascular diseases (CVDs) normally resulting in organ failure and death. Cardiac fibroblasts (CFs) play an
Externí odkaz:
https://doaj.org/article/cdbc02ced7164c419f84ca88aa0120af