PYCR1 promotes liver cancer cell growth and metastasis by regulating IRS1 expression through lactylation modification.

Autor: Wang H; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Xu M; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China., Zhang T; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Pan J; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Li C; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Pan B; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China., Zhou L; School of Basic Medicine and Clinical Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China., Huang Y; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Gao C; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., He M; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Xue Y; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Ji X; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Zhang X; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Wang N; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Zhou H; Department of Endocrinology, The First affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China., Wang Q; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China., Li JZ; The Key Laboratory of Rare Metabolic Disease, Department of Biochemistry and Molecular Biology, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Endocrinology, The affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Northern Jiangsu Institute of Clinical Medicine, Huaian, Jiangsu, China.; Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2024 Oct; Vol. 14 (10), pp. e70045.

Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells.

Autor: Park JM; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan., Su YH; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Fan CS; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Chen HH; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan., Qiu YK; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan., Chen LL; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Chen HA; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.; Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Ramasamy TS; Stem Cell Biology Laboratory, Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia., Chang JS; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan., Huang SY; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan., Chang WW; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Lee AY; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Huang TS; National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan., Kuo CC; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan. kuocc@nhri.org.tw.; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan. kuocc@nhri.org.tw., Chiu CF; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan. chiucf@tmu.edu.tw.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan. chiucf@tmu.edu.tw.; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. chiucf@tmu.edu.tw.; Taipei Medical University and Affiliated Hospitals Pancreatic Cancer Groups, Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan. chiucf@tmu.edu.tw.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2024 Sep; Vol. 56 (9), pp. 2065-2081. Date of Electronic Publication: 2024 Sep 18.

Confirming the enzymatic activity and neurodevelopmental trajectory of PYCR1 mutation in one child with autosomal-recessive cutis laxa type 2.

Autor: Shangguan S; Department of Medical Genetics, Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China., Zhang X; Department of Children's Nutrition Research Center, Affiliated Children's Hospital of Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China., Ge Y; Department of Medical Genetics, Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China., Han Y; Department of Neurology, Affiliated Children's hospital of Capital Institute of Pediatrics, Beijing, China., Xiao L; Department of Children's Nutrition Research Center, Affiliated Children's Hospital of Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China., Zhang Y; Department of Laboratory Center, Capital Institute of Pediatrics, Beijing, China., Xie H; Department of Medical Genetics, Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China., Chen X; Department of Medical Genetics, Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China. xiaolichen@pumc.edu.cn., Wang X; Department of Children's Nutrition Research Center, Affiliated Children's Hospital of Capital Institute of Pediatrics, Yabao Road, Chaoyang District, Beijing, 100020, China. yanziskyv@126.com.

Publikováno v: Molecular genetics and genomics : MGG [Mol Genet Genomics] 2024 Aug 22; Vol. 299 (1), pp. 81. Date of Electronic Publication: 2024 Aug 22.

Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1).

Autor: Meeks KR; Department of Biochemistry, University of Missouri, Columbia, Missouri, USA., Bogner AN; Department of Biochemistry, University of Missouri, Columbia, Missouri, USA., Tanner JJ; Department of Biochemistry, University of Missouri, Columbia, Missouri, USA.; Department of Chemistry, University of Missouri, Columbia, Missouri, USA.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Jul; Vol. 33 (7), pp. e5072.

Metabolic characterization of sphere-derived prostate cancer stem cells reveals aberrant urea cycle in stemness maintenance.

Autor: Luo Y; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China.; University of Chinese Academy of Sciences, Beijing, China., Yu J; Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Lin Z; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China., Wang X; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China., Zhao J; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China.; University of Chinese Academy of Sciences, Beijing, China., Liu X; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China., Qin W; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China., Xu G; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.; State Key Laboratory of Medical Proteomics, Beijing, China.; Liaoning Province Key Laboratory of Metabolomics, Dalian, China.

Publikováno v: International journal of cancer [Int J Cancer] 2024 Aug 15; Vol. 155 (4), pp. 742-755. Date of Electronic Publication: 2024 Apr 22.