Výsledky vyhledávání - "carboxy terminus"

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Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

Autor: Arun Upadhyay

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2995-3014 (2021)
Acta Pharmaceutica Sinica. B

Cells have different sets of molecules for performing an array of physiological functions. Nucleic acids have stored and carried the information throughout evolution, whereas proteins have been attributed to performing most of the cellular functions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5576b50a2ff37b0f37fd10602f606f6c
http://www.sciencedirect.com/science/article/pii/S2211383521000095

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Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications

Autor: Maria Almira Correia, Sung-Mi Kim, Doyoung Kwon

Publikováno v: Acta Pharmaceutica Sinica. B
Acta pharmaceutica Sinica. B, vol 10, iss 1
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 42-60 (2020)

The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-function oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b693f8b63f9fc633d41381151847be33
https://doi.org/10.1016/j.apsb.2019.11.002

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Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1

Autor: Maider López de Jesús, Susana Mato, Sergio Barrondo, Xabier Aretxabala, Miquel Saumell-Esnaola, Catherine Ledent, Leire Borrega-Roman, Carlos Matute, Leyre Echeazarra, M.A. Goicolea, Imanol González-Burguera, Gontzal García del Caño, Joan Sallés

Publikováno v: Histochemistry and Cell Biology

Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low performance of antibodies r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b730cb3584196109ce4dc19d22f8d
http://europepmc.org/articles/PMC8604870

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Arginine‐ but not alanine‐rich carboxy‐termini trigger nuclear translocation of mutant keratin 10 in ichthyosis with confetti

Autor: Andreas Volz, Hedwig Wariwoda, I. Spoerri, Peter Itin, Bettina Burger, M. Aushev, Julia Reichelt, E. Imahorn, Oliver Patrick March, Patricia Renz, Sarah Von Arb

Publikováno v: Journal of Cellular and Molecular Medicine

Ichthyosis with confetti (IWC) is a genodermatosis associated with dominant‐negative variants in keratin 10 (KRT10) or keratin 1 (KRT1). These frameshift variants result in extended aberrant proteins, localized to the nucleus rather than the cytopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935cdfe3e072440d5bd2d05ae4c9a4df
https://doi.org/10.1111/jcmm.14727

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Dealing with difficult clients via personalized chaperone inhibitors

Autor: Andrew W. Truman

Publikováno v: The Journal of Biological Chemistry

The importance of molecular chaperones in cancer is well established, yet several chaperone inhibitors have failed in clinical trials due to toxicity. Recent efforts have focused on targeting chaperone function in cancer by either manipulating the "c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684ecdf9ba9460addc4e492e4ac9930a
https://pubmed.ncbi.nlm.nih.gov/33837724

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Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor

Autor: Echeazarra Escudero, Leire, García del Caño, Gontzal, Barrondo Lacarra, Sergio, González Burguera, Imanol, Saumell Esnaola, Miquel, Aretxabala Rodríguez, Xabier, López de Jesús, Maider, Borrega Román, Leire, Mato Santos, Susana, Ledent, Catherine, Matute Almau, Carlos José, Goicolea Altuna, María Aranzazu, Sallés Alvira, Joan

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e62c83b33a8c478837f60d8e9cb26ef6
http://hdl.handle.net/10810/55073

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Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H

Autor: Renata F. Soares, Gopal P. Sapkota, Ana Gázquez-Gutiérrez, Nicola T. Wood, Luke J. Fulcher, Theresa Tachie-Menson, Robert Gourlay, Joby Varghese, Thomas Macartney

Publikováno v: Cellular Signalling

The majority of mutations identified in patients with amelogenesis imperfecta have been mapped to FAM83H. As FAM83H expression is not limited to the enamel, how FAM83H contributes to amelogenesis is still largely unknown. We previously reported that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a3ce886c5dc6e8e666e7bdd12e63e6
https://pubmed.ncbi.nlm.nih.gov/32289446

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