The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants

Autor: Philipp F. Popp, Tania Lozano-Cruz, Franziska Dürr, Addis Londaitsbehere, Johanna Hartig, Francisco Javier de la Mata, Rafael Gómez, Thorsten Mascher, Ainhoa Revilla-Guarinos

Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 297 (2023)

The threat of antimicrobial-resistant bacteria is ever increasing and over the past-decades development of novel therapeutic counter measurements have virtually come to a halt. This circumstance calls for interdisciplinary approaches to design, evalu

Externí odkaz: https://doaj.org/article/7da6de9e1725406485310ba538d0b39b

Synthesis and mechanism-of-action of a novel synthetic antibiotic based on a dendritic system with bow-tie topology.

Autor: Revilla-Guarinos A; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., Popp PF; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., Dürr F; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., Lozano-Cruz T; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University de Alcalá, Madrid, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain., Hartig J; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., de la Mata FJ; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University de Alcalá, Madrid, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain., Gómez R; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University de Alcalá, Madrid, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain., Mascher T; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2022 Aug 26; Vol. 13, pp. 912536. Date of Electronic Publication: 2022 Aug 26 (Print Publication: 2022).