Synthesis and mechanism-of-action of a novel synthetic antibiotic based on a dendritic system with bow-tie topology

Autor: Ainhoa Revilla-Guarinos, Philipp F. Popp, Franziska Dürr, Tania Lozano-Cruz, Johanna Hartig, Francisco Javier de la Mata, Rafael Gómez, Thorsten Mascher

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Over the course of the last decades, the continuous exposure of bacteria to antibiotics—at least in parts due to misprescription, misuse, and misdosing—has led to the widespread development of antimicrobial resistances. This development poses a t

Externí odkaz: https://doaj.org/article/3aff01a886db4fbdb7afe1cf4db4fa35

The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants

Autor: Philipp F. Popp, Tania Lozano-Cruz, Franziska Dürr, Addis Londaitsbehere, Johanna Hartig, Francisco Javier de la Mata, Rafael Gómez, Thorsten Mascher, Ainhoa Revilla-Guarinos

Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 297 (2023)

The threat of antimicrobial-resistant bacteria is ever increasing and over the past-decades development of novel therapeutic counter measurements have virtually come to a halt. This circumstance calls for interdisciplinary approaches to design, evalu

Externí odkaz: https://doaj.org/article/7da6de9e1725406485310ba538d0b39b

Synthesis and mechanism-of-action of a novel synthetic antibiotic based on a dendritic system with bow-tie topology.

Autor: Revilla-Guarinos A; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., Popp PF; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., Dürr F; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., Lozano-Cruz T; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University de Alcalá, Madrid, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain., Hartig J; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany., de la Mata FJ; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University de Alcalá, Madrid, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain., Gómez R; Department of Organic and Inorganic Chemistry, Research Institute in Chemistry 'Andrés M. Del Río' (IQAR), University de Alcalá, Madrid, Spain.; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.; Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain., Mascher T; Department of General Microbiology, Institut Für Mikrobiologie, Technische Universität Dresden, Dresden, Germany.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2022 Aug 26; Vol. 13, pp. 912536. Date of Electronic Publication: 2022 Aug 26 (Print Publication: 2022).