Zobrazeno 1 - 10
of 184
pro vyhledávání: '"carbasugar"'
Publikováno v:
Molecules, Vol 29, Iss 20, p 4870 (2024)
Glycoside hydrolases have been implicated in a wide range of human conditions including lysosomal storage diseases. Consequently, many researchers have directed their efforts towards identifying new classes of glycoside hydrolase inhibitors, both syn
Externí odkaz:
https://doaj.org/article/b22d705092f045858673c53a8b27fbd2
Akademický článek
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Autor:
Patrick Weber, Martin Thonhofer, Summer Averill, Gideon J. Davies, Andres Gonzalez Santana, Philipp Müller, Seyed A. Nasseri, Wendy A. Offen, Bettina M. Pabst, Eduard Paschke, Michael Schalli, Ana Torvisco, Marion Tschernutter, Christina Tysoe, Werner Windischhofer, Stephen G. Withers, Andreas Wolfsgruber, Tanja M. Wrodnigg, Arnold E. Stütz
Publikováno v:
Molecules, Vol 25, Iss 17, p 4025 (2020)
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaper
Externí odkaz:
https://doaj.org/article/25403e0b400e40b799edabad23624a55
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 9, Iss 3, Pp 401-421 (2008)
Pericosines are unique C7 cyclohexenoid metabolites of Periconia byssoides OUPS-N133 fungus that was originally isolated from the sea hare, Aplysia kurodai. Pericosines show significant in vitro cytotoxicity against P388 lymphocytic leukemia cells. P
Externí odkaz:
https://doaj.org/article/60a15cecaa964940a6d058e34be47ddf
Autor:
Gideon J. Davies, Casper de Boer, Herman S. Overkleeft, Wendy A. Offen, Jacopo Enotarpi, Gijsbert A. van der Marel, Jeroen D. C. Codée, Sybrin P. Schröder, Laura Marino, Bogdan I. Florea, Alexandra Males, Yi Jin
Publikováno v:
CHEM-EUR J, 27(37), 9519-9523. WILEY-V C H VERLAG GMBH
Schröder, S P, Offen, W A, Males, A, Jin, Y, Boer, C, Enotarpi, J, Marino, L, Marel, G A, Florea, B I, Codée, J D C, Overkleeft, H S & Davies, G J 2021, ' Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on alpha-1,6 Mannanases ', Chemistry – A European Journal, vol. 27, no. 37, pp. 9519-9523 . https://doi.org/10.1002/chem.202101255
Chemistry (Weinheim an Der Bergstrasse, Germany)
Schröder, S P, Offen, W A, Males, A, Jin, Y, Boer, C, Enotarpi, J, Marino, L, Marel, G A, Florea, B I, Codée, J D C, Overkleeft, H S & Davies, G J 2021, ' Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on alpha-1,6 Mannanases ', Chemistry – A European Journal, vol. 27, no. 37, pp. 9519-9523 . https://doi.org/10.1002/chem.202101255
Chemistry (Weinheim an Der Bergstrasse, Germany)
There is a vast genomic resource for enzymes active on carbohydrates. Lagging far behind, however, are functional chemical tools for the rapid characterization of carbohydrate‐active enzymes. Activity‐based probes (ABPs) offer one chemical soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503a40aafc1803d748abf9432d41357f
http://hdl.handle.net/1887/3205317
http://hdl.handle.net/1887/3205317
Autor:
Michael Schalli, Seyed A. Nasseri, Werner Windischhofer, Ana Torvisco, Christina Tysoe, Wendy A. Offen, Stephen G. Withers, Patrick Weber, Philipp Müller, Marion Tschernutter, Summer Averill, Eduard Paschke, Andreas Wolfsgruber, Martin Thonhofer, Bettina M. Pabst, Arnold E. Stütz, Tanja M. Wrodnigg, Gideon J. Davies, Andrés G. Santana
Publikováno v:
Molecules
Molecules, Vol 25, Iss 4025, p 4025 (2020)
Volume 25
Issue 17
Molecules, Vol 25, Iss 4025, p 4025 (2020)
Volume 25
Issue 17
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid &beta
galactosidase inhibitors were prepared and their inhibitory and pharmacologica
galactosidase inhibitors were prepared and their inhibitory and pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a21aebf7315b8edceb182918f2e34f2
https://eprints.whiterose.ac.uk/167565/1/molecules_25_04025_v3.pdf
https://eprints.whiterose.ac.uk/167565/1/molecules_25_04025_v3.pdf
Autor:
Ayse Tan
In this study, novel 1,2,3-triazole compounds containing carbasugar frameworks (5 and 6) were synthesized by the copper-catalyzed azide-alkyne cycloaddition reactions and their in vitro inhibition effects on the enzyme xanthine oxidase were investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147c05566aef7595dc1c5cc82253ecfa
https://hdl.handle.net/20.500.12639/2202
https://hdl.handle.net/20.500.12639/2202
Akademický článek
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Autor:
Huntsman, Andrew C.
Natural products were once the only source of medicine and, since the dawn of modern drug discovery, have continued to serve as inspiration for the development of novel pharmaceuticals. The use of purified plant constituents greatly advanced the trea