Zobrazeno 1 - 10
of 106
pro vyhledávání: '"capillary transit time heterogeneity"'
Autor:
Sebastian C. Schneider, Mario E. Archila-Meléndez, Jens Göttler, Stephan Kaczmarz, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Publikováno v:
NeuroImage, Vol 255, Iss , Pp 119208- (2022)
Functional connectivity (FC) derived from blood oxygenation level dependent (BOLD) functional magnetic resonance imaging at rest (rs-fMRI), is commonly interpreted as indicator of neuronal connectivity. In a number of brain disorders, however, metabo
Externí odkaz:
https://doaj.org/article/0099ee4ebb2542dd80a277f65e258922
Autor:
Björn B. Hofmann, Igor Fischer, Daniel M. Donaldson, Yousef Abusabha, Cihat Karadag, Sajjad Muhammad, Kerim Beseoglu, Daniel Hänggi, Bernd Turowski, Christian Rubbert, Jan F. Cornelius, Marcel A. Kamp
Publikováno v:
Brain Sciences, Vol 13, Iss 5, p 824 (2023)
The concept of early brain injury (EBI) is based on the assumption of a global reduction in brain perfusion following aneurysmal subarachnoid hemorrhage (aSAH). However, the heterogeneity of computed tomography perfusion (CTP) imaging in EBI has not
Externí odkaz:
https://doaj.org/article/40dce8faa9784fe5ace27f0092d96bcd
Autor:
Rune B. Nielsen, Peter Parbo, Rola Ismail, Rikke Dalby, Anna Tietze, Hans Brændgaard, Hanne Gottrup, David J. Brooks, Leif Østergaard, Simon F. Eskildsen
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Cardiovascular disease increases the risk of developing Alzheimer's disease (AD), and growing evidence suggests an involvement of cerebrovascular pathology in AD. Capillary dysfunction, a condition in which capillary flow distur
Externí odkaz:
https://doaj.org/article/c8611cfcd4714bfc89312f75d42fd35a
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Brain metabolism is highly dependent on continuous oxygen supply. Cortical microvascular networks exhibit heterogeneous blood flow, leading to non-uniform tissue oxygenation and capillary hemoglobin saturation. We recently proposed capillary outflow
Externí odkaz:
https://doaj.org/article/21d4f9a7bb5b48f4b6adc2fb60205a64
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Capillary dysfunction impairs oxygen supply to parenchymal cells and often occurs in Alzheimer's disease, diabetes and aging. Disturbed capillary flow patterns have been shown to limit the efficacy of oxygen extraction and can be quantified using cap
Externí odkaz:
https://doaj.org/article/d26e15e410a2492badc4d036d0b90f77
Akademický článek
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Autor:
Christian Gerloff, Bastian Cheng, Julian Schröder, Jan Sedlacik, Bernardo Crespo Pimentel, Marlene Heinze, Jens Fiehler, Leif Østergaard, Götz Thomalla
Publikováno v:
Crespo Pimentel, B, Sedlacik, J, Schröder, J, Heinze, M, Østergaard, L, Fiehler, J, Gerloff, C, Thomalla, G & Cheng, B 2022, ' Comprehensive Evaluation of Cerebral Hemodynamics and Oxygen Metabolism in Revascularization of Asymptomatic High-Grade Carotid Stenosis ', Clinical neuroradiology, vol. 32, no. 1, pp. 163-173 . https://doi.org/10.1007/s00062-021-01077-3
Introduction Revascularization procedures in carotid artery stenosis have shown a positive effect in the restoration of cerebral oxygen metabolism as assessed by T2’ (T2 prime) imaging as well as capillary homeostasis by measurement of capillary tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49eae1f81494a3bfe4f79d7c76a2383b
https://pure.au.dk/portal/da/publications/comprehensive-evaluation-of-cerebral-hemodynamics-and-oxygen-metabolism-in-revascularization-of-asymptomatic-highgrade-carotid-stenosis(07b34c5a-1d5a-45e5-ac9a-1786a4c063d4).html
https://pure.au.dk/portal/da/publications/comprehensive-evaluation-of-cerebral-hemodynamics-and-oxygen-metabolism-in-revascularization-of-asymptomatic-highgrade-carotid-stenosis(07b34c5a-1d5a-45e5-ac9a-1786a4c063d4).html
Publikováno v:
Frontiers in Computational Neuroscience, Vol 10 (2016)
Glucose is the brain’s principal source of ATP, but the extent to which cerebral glucose consumption (CMRglc) is coupled with its oxygen consumption (CMRO2) remains unclear. Measurements of the brain’s oxygen-glucose index OGI=CMRO2/CMRglc sugges
Externí odkaz:
https://doaj.org/article/2217705b2b65492c8023c001056dd3b3
Autor:
Hugo Angleys, Leif Østergaard
Publikováno v:
Angleys, H & Østergaard, L 2020, ' Krogh's capillary recruitment hypothesis, 100 years on : Is the opening of previously closed capillaries necessary to ensure muscle oxygenation during exercise? ', A J P: Heart and Circulatory Physiology (Online), vol. 318, no. 2, pp. H425-H447 . https://doi.org/10.1152/ajpheart.00384.2019
In 1919, August Krogh published his seminal work on skeletal muscle oxygenation. Krogh’s observations indicated that muscle capillary diameter is actively regulated, rather than a passive result of arterial blood flow regulation. Indeed, combining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d363b1c41e2259e031060ae13604d9a5
https://doi.org/10.1152/ajpheart.00384.2019
https://doi.org/10.1152/ajpheart.00384.2019
Publikováno v:
Dalby, R B, Eskildsen, S F, Videbech, P, Rosenberg, R & Østergaard, L 2021, ' Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder ', Psychiatry Research-Neuroimaging, vol. 317, 111383 . https://doi.org/10.1016/j.pscychresns.2021.111383
Dalby, R B, Eskildsen, S F, Videbech, P, Rosenberg, R & Østergaard, L 2021, ' Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder ', Psychiatry Research-Neuroimaging, vol. 317, 111383, pp. 1-10 . https://doi.org/10.1016/j.pscychresns.2021.111383
Dalby, R B, Eskildsen, S F, Videbech, P, Rosenberg, R & Østergaard, L 2021, ' Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder ', Psychiatry Research-Neuroimaging, vol. 317, 111383, pp. 1-10 . https://doi.org/10.1016/j.pscychresns.2021.111383
In major depressive disorder (MDD), perfusion changes in cortico-limbic pathways are interpreted as altered neuronal activity, but they could also signify changes in neurovascular coupling due to altered capillary function. To examine capillary funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8cf4399822d49334560679c13b31c4
https://pure.au.dk/ws/files/273932772/1_s2.0_S0925492721001359_main.pdf
https://pure.au.dk/ws/files/273932772/1_s2.0_S0925492721001359_main.pdf