Zobrazeno 1 - 10
of 276
pro vyhledávání: '"capicua"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Capicua (CIC)-rearranged sarcomas are an aggressive subset of undifferentiated round cell sarcomas. CIC::DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid clinical progression and chemotherapy resistance leading to poor clinical
Externí odkaz:
https://doaj.org/article/e276c5f5b5e84ccab299f708f5d8800e
Autor:
Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim, Şevin Turcan
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived
Externí odkaz:
https://doaj.org/article/fa0f02994ce642d6bf67a50fef6ccde1
Akademický článek
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Autor:
Nehal Gupta, Hanbing Song, Wei Wu, Rovingaile K Ponce, Yone K Lin, Ji Won Kim, Eric J Small, Felix Y Feng, Franklin W Huang, Ross A Okimoto
Publikováno v:
eLife, Vol 11 (2022)
Human prostate cancer can result from chromosomal rearrangements that lead to aberrant ETS gene expression. The mechanisms that lead to fusion-independent ETS factor upregulation and prostate oncogenesis remain relatively unknown. Here, we show that
Externí odkaz:
https://doaj.org/article/0eb13355c7624b8981b2504410da190b
Autor:
Derek Wong, Lisa Sogerer, Samantha S. Lee, Victor Wong, Amy Lum, Adrian B. Levine, Marco A. Marra, Stephen Yip
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through the derepression of targets downstream of the mitogen-activated protein kinase (MAPK) signaling casc
Externí odkaz:
https://doaj.org/article/bb8ef9269ef84a15aa79c7b42e24e8e5
Autor:
Jeon-Soo Lee, Eunjeong Kim, Jongeun Lee, Donghyo Kim, Hyeongjoo Kim, Chang-Jin Kim, Sanguk Kim, Dongjun Jeong, Yoontae Lee
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Although major driver gene mutations have been identified, the complex molecular heterogeneity of colorectal cancer (CRC) remains unclear. Capicua (CIC) functions as a tumor suppressor in various types of cancers; however, its rol
Externí odkaz:
https://doaj.org/article/18afbc7673c3493ca69115eb50bd537c
Autor:
Tomomi Hashiba, Taro Yamashita, Hikari Okada, Kouki Nio, Takehiro Hayashi, Yoshiro Asahina, Tomoyuki Hayashi, Takeshi Terashima, Noriho Iida, Hajime Takatori, Tetsuro Shimakami, Kazunori Kawaguchi, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Hiroyuki Takamura, Tetsuo Ohta, Masao Honda, Shuichi Kaneko
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 269-285 (2020)
Background & Aims: Sorafenib is a multireceptor tyrosine kinase inhibitor that can prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Although most HCC patients who receive sorafenib ultimately show disease progression
Externí odkaz:
https://doaj.org/article/409a21be26b2439b9bc0639766241eeb
Publikováno v:
eLife, Vol 10 (2021)
Central tolerance is achieved through positive and negative selection of thymocytes mediated by T cell receptor (TCR) signaling strength. Thus, dysregulation of the thymic selection process often leads to autoimmunity. Here, we show that Capicua (CIC
Externí odkaz:
https://doaj.org/article/750cfe750b534b1f82aec2f59998e216
Autor:
Keqin Li, Shuai Shao, Tongjie Ji, Min Liu, Lufeng Wang, Ying Pang, Mu Chen, Siyi Xu, Kuiming Zhang, Qi Wang, Zhongwei Zhuang, Liang Wei, Yanfei Zhang, Yanlin Chen, Yang Wang, Jing Zhang, Kui Chen, Hao Lian, Chunlong Zhong
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
Capicua (Cic), a transcriptional repressor frequently mutated in brain cancer oligodendroglioma, is highly expressed in adult neurons. However, its function in the dendritic growth of neurons in the hippocampus remains poorly understood. Here, we con
Externí odkaz:
https://doaj.org/article/5918075d2328459e9ed8f90301d4fe9e
Autor:
Tan, Qiumin, Brunetti, Lorenzo, Rousseaux, Maxime W. C., Lu, Hsiang-Chih, Wan, Ying-Wooi, Revelli, Jean-Pierre, Liu, Zhandong, Goodell, Margaret A., Zoghbi, Huda Y.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Feb . 115(7), E1511-E1519.
Externí odkaz:
https://www.jstor.org/stable/26507387