Zobrazeno 1 - 7
of 7
pro vyhledávání: '"cancer target discovery"'
Autor:
Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells
Publikováno v:
eLife, Vol 7 (2018)
While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on ce
Externí odkaz:
https://doaj.org/article/effb67b1d9ed4b8785dee707219f397c
Autor:
Filemon S. Dela Cruz, Hiroyuki Yoda, Calvin J. Kuo, William C. Hahn, Kelly Kersten, Olivier Gevaert, Michitaka Nakano, Bruce K. Hua, Yohannes Tsehay, Han Liang, Yun Rose Li, Taofeek K. Owonikoko, Yunqi Yan, Katherine N. Liu, Stephen E. Kurtz, Andrew J. Ewald, Gordon B. Mills, Matthew Dunworth, Yuhao Wang, Eloise M. Grasset, Joseph Estabrook, Nicola Long, Vasanthi S. Viswanathan, Bridget Robinson, Shubhroz Gill, Matthew C. Perrone, Ken Chen, Suresh S. Ramalingam, Robert T. Manguso, Asmita Bhattacharya, Andrea Califano, Wei Zhou, Yuhong Du, Elodie Henriet, Jordana Brown, Francisca Vazquez, Michael T. McManus, Manisha Warrier, Gabriel Eades, Anuja Sathe, Yilong Zou, Yoko Kosaka, Matthew A. Reyna, Theodore P. Braun, Daniela S. Gerhard, Matthew F. Krummel, Allan Balmain, Tamilla Nechiporuk, Hanlee P. Ji, Quin Morrow, Emek Demir, Pablo Tamayo, Jessica Minnier, Michael C. Bassik, Kevin Watanabe-Smith, Xiulei Mo, Qi-Wen Fan, Nicole Nasholm, Sagar Lonial, Stuart L. Schreiber, Brent R. Stockwell, Nina K. Serwas, Sourav Bandyopadhyay, Brian J. Druker, Christina Curtis, Yuan-Hung Lo, Olga Nikolova, Qiankun Niu, Veena Padmanaban, Yuchen Ge, Cristina E. Tognon, Anupriya Agarwal, Christopher J. Kemp, Kremena Karagyozova, Haian Fu, Trevor Bivona, Dan Georgess, Nidhi Sahni, Stefan Oberlin, Issac S. Chan, Michael G. Lerner, Matt Hangauer, Jennifer Saultz, Wing Hing Wong, Ilya Shmulevich, Christin Schmidt, Yasir Suhail, Andy Kaempf, Alan Ashworth, Saumya R. Bollam, Tanaz Sharifnia, Jesse S. Boehm, Kasper Karlsson, Carlos S. Moreno, Neil Tay, Michael Grzadkowski, Kevin C. Brennan, Subhashini Jagu, Elizabeth M. Swisher, Ben Deneen, Jessica A. Talamas, Amber R. Smith, Joel S. Bader, Vlado Dančík, Andrew L. Kung, William A. Weiss, Hildur Knutsdottir, Tania Q. Vu, Lee Cooper, Kanako Yuki, Wei-Ching Chen, Bridget K. Wagner, Evan F. Lind, Josh Dempster, Marie Menard, Carla Grandori, Andrey A. Ivanov, William Kim, Jeffrey W. Tyner, Jonathan S. Weissman, Thomas Jacob, Paul A. Clemons, Jitong Cai, Kaitlyn Spees, Dan S. Kaufman
Publikováno v:
Cell, vol 184, iss 5
Cell
Cell
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9eecba249a534391089dc341a11f66
https://doi.org/10.1016/j.cell.2021.02.020
https://doi.org/10.1016/j.cell.2021.02.020
Autor:
Jonathan S. Weissman, Alexander J. Martinko, Josip Blonder, Olivier Julien, Charles Truillet, Michael J. Evans, Juan E. Diaz, Sourav Bandyopadhyay, Max A. Horlbeck, Gordon Whiteley, James A. Wells
Publikováno v:
eLife, Vol 7 (2018)
eLife
Martinko, AJ; Truillet, C; Julien, O; Diaz, JE; Horlbeck, MA; Whiteley, G; et al.(2018). Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.. eLife, 7. doi: 10.7554/eLife.31098. UCSF: Retrieved from: http://www.escholarship.org/uc/item/69r3960v
eLife
Martinko, AJ; Truillet, C; Julien, O; Diaz, JE; Horlbeck, MA; Whiteley, G; et al.(2018). Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.. eLife, 7. doi: 10.7554/eLife.31098. UCSF: Retrieved from: http://www.escholarship.org/uc/item/69r3960v
While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33e9ddd66fe69b9899ba8734640e86f
https://elifesciences.org/articles/31098
https://elifesciences.org/articles/31098
Autor:
James D. Marks, Shauna Farr-Jones, Hao Zou, Christina Yau, Lequn Zhao, Yu Zhou, Christopher C. Benz, Steven C. Hall, Daryl C. Drummond, John W. Park
Publikováno v:
Protein engineering, design & selection : PEDS, vol 31, iss 1
We present a strategy to discover recombinant monoclonal antibodies (mAbs) to specific cancers and demonstrate this approach using basal subtype breast cancers. A phage antibody library was depleted of antibodies to common cell surface molecules by i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ab2d232abbbeb22d974d5b28372807
https://escholarship.org/uc/item/30w0m2rs
https://escholarship.org/uc/item/30w0m2rs
Publikováno v:
Molecular cancer research : MCR, vol 14, iss 8
The Cancer Target Discovery and Development (CTD(2)) Network was established to accelerate the transformation of "Big Data" into novel pharmacologic targets, lead compounds, and biomarkers for rapid translation into improved patient outcomes. It rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::801c99c1e981a7e97e458b0d16a03bbd
https://escholarship.org/uc/item/211116vx
https://escholarship.org/uc/item/211116vx
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Martinko AJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, San Francisco, United States., Truillet C; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, United States., Julien O; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Diaz JE; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Horlbeck MA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States., Whiteley G; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, United States., Blonder J; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, United States., Weissman JS; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, United States., Bandyopadhyay S; Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, United States., Evans MJ; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, United States., Wells JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Publikováno v:
ELife [Elife] 2018 Jan 23; Vol. 7. Date of Electronic Publication: 2018 Jan 23.