Zobrazeno 1 - 10
of 908
pro vyhledávání: '"cancer systems biology"'
Autor:
Norbert Moldovan, Sandra Verkuijlen, Ymke van der Pol, Leontien Bosch, Jan R.T. van Weering, Idris Bahce, D. Michiel Pegtel, Florent Mouliere
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110742- (2024)
Summary: Blood contains multiple analytes that can be used as liquid biopsy to analyze cancer. Mutations have been detected in DNA associated with small extracellular vesicles (sEVs). The genome-wide composition and structure of sEV DNA remains poorl
Externí odkaz:
https://doaj.org/article/5f34ee0e26cb412d835d0c29a2af68ee
Autor:
Óscar Lapuente-Santana, Gregor Sturm, Joan Kant, Markus Ausserhofer, Constantin Zackl, Maria Zopoglou, Nicholas McGranahan, Dietmar Rieder, Zlatko Trajanoski, Noel Filipe da Cunha Carvalho de Miranda, Federica Eduati, Francesca Finotello
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110529- (2024)
Summary: The cellular and molecular heterogeneity of tumors is a major obstacle to cancer immunotherapy. Here, we use a systems biology approach to derive a signature of the main sources of heterogeneity in the tumor microenvironment (TME) from lung
Externí odkaz:
https://doaj.org/article/6177426cd53a47f8b485b6ac42525e16
Autor:
Qizhi Zhu, Meng Fu, Jian Qi, Ziming Xu, Yongguang Wang, Zhipeng Wang, Dan Wang, Jiajia Liu, Ruiping Du, Xin Wei, Hongzhi Wang, Jinfu Nie, Bo Hong, Weiping Xu
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110413- (2024)
Summary: Platinum-based chemo-resistance is the major issue for the treatment of small cell lung cancer (SCLC). The integrative analysis of multi-omics data is a reliable approach for discovering novel biomarkers associated with chemo-resistance. Her
Externí odkaz:
https://doaj.org/article/10ad811d4e8f4936b675944207aaabfb
Autor:
Álvaro Cano, Marina L. Yubero, Carmen Millá, Verónica Puerto-Belda, Jose J. Ruz, Priscila M. Kosaka, Montserrat Calleja, Marcos Malumbres, Javier Tamayo
Publikováno v:
iScience, Vol 27, Iss 11, Pp 110960- (2024)
Summary: Predicting the phenotypic impact of genetic variants and treatments is crucial in cancer genetics and precision oncology. Here, we have developed a noise decorrelation method that enables quantitative phase imaging (QPI) with the capability
Externí odkaz:
https://doaj.org/article/a886ef0489354cdc83e7e5a6c51e87a4
Autor:
Linjing Liu, Ying Xiong, Zetian Zheng, Lei Huang, Jiangning Song, Qiuzhen Lin, Buzhou Tang, Ka-Chun Wong
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110183- (2024)
Summary: Current studies in early cancer detection based on liquid biopsy data often rely on off-the-shelf models and face challenges with heterogeneous data, as well as manually designed data preprocessing pipelines with different parameter settings
Externí odkaz:
https://doaj.org/article/cc58a362f80c4d23a7bdff6edb011144
Autor:
Sarthak Sahoo, Soundharya Ramu, Madhumathy G. Nair, Maalavika Pillai, Beatriz P. San Juan, Heloisa Zaccaron Milioli, Susmita Mandal, Chandrakala M. Naidu, Apoorva D. Mavatkar, Harini Subramaniam, Arpita G. Neogi, Christine L. Chaffer, Jyothi S. Prabhu, Jason A. Somarelli, Mohit Kumar Jolly
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110116- (2024)
Summary: Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. Decoding the interconnections among different biological axes of plasticity is crucial to understand the mol
Externí odkaz:
https://doaj.org/article/184f963418524796bef6f9437338f851
Autor:
Camille Tlemsani, Christine M. Heske, Fathi Elloumi, Lorinc Pongor, Prashant Khandagale, Sudhir Varma, Augustin Luna, Paul S. Meltzer, Javed Khan, William C. Reinhold, Yves Pommier
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109781- (2024)
Summary: Sarcomas are a diverse group of rare malignancies composed of multiple different clinical and molecular subtypes. Due to their rarity and heterogeneity, basic, translational, and clinical research in sarcoma has trailed behind that of other
Externí odkaz:
https://doaj.org/article/ebd4320ef1c24a3cbaaa4ee2f674d992
Autor:
Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109913- (2024)
Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells. Noncancerous cells—despite high expre
Externí odkaz:
https://doaj.org/article/2f54004c83044be5bd8ac35ee92cdfc3
Autor:
Anna Hakobyan, Mathilde Meyenberg, Nelli Vardazaryan, Joel Hancock, Loan Vulliard, Joanna I. Loizou, Jörg Menche
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109873- (2024)
Summary: Cancer is a multi-faceted disease with intricate relationships between mutagenic processes, alterations in cellular signaling, and the tissue microenvironment. To date, these processes have been largely studied in isolation. A systematic und
Externí odkaz:
https://doaj.org/article/6b65954581d04d98a91f73fe7f6964e5
Autor:
Li Wang, Sudeh Izadmehr, John P. Sfakianos, Michelle Tran, Kristin G. Beaumont, Rachel Brody, Carlos Cordon-Cardo, Amir Horowitz, Robert Sebra, William K. Oh, Nina Bhardwaj, Matthew D. Galsky, Jun Zhu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109928- (2024)
Summary: Interactions within the tumor microenvironment (TME) significantly influence tumor progression and treatment responses. While single-cell RNA sequencing (scRNA-seq) and spatial genomics facilitate TME exploration, many clinical cohorts are a
Externí odkaz:
https://doaj.org/article/78cfe216b02f40508c2ce44eed5d4500