Zobrazeno 1 - 10
of 143
pro vyhledávání: '"cancer immune therapy"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory m
Externí odkaz:
https://doaj.org/article/4b57a07e1bda42679b4295753dcebc0a
Autor:
Yongji Jiang, Chuyuan Chen, Yuan Liu, Rong Wang, Chuan Feng, Lili Cai, Shuang Chang, Lei Zhao
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInterleukin-2 (IL-2) is one of the first cytokines to be discovered as an immune agonist for cancer immunotherapy. Biased IL-2 variants had been discovered to eliminate Treg activation or enhance the tumor specific T cell cytotoxicity. Ho
Externí odkaz:
https://doaj.org/article/2786776c7a4448c086ec2c2d8aa3a66e
Publikováno v:
Cancer Reports, Vol 7, Iss 2, Pp n/a-n/a (2024)
Abstract Objectives To analyze the clinical characteristics and influencing factors of hepatotoxicity in patients with advanced hepatocellular carcinoma (HCC) treated with programmed cell death protein‐1 (PD‐1) inhibitors, and to provide a theore
Externí odkaz:
https://doaj.org/article/7dad1a816e0642b48fcc09ae81d44891
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Cancer progression and metastasis due to tumor immune evasion and drug resistance is strongly associated with immune suppressive cellular responses, particularly in the case of metastatic tumors. The myeloid cell component plays a key role within the
Externí odkaz:
https://doaj.org/article/c3d6ad7d58c345bfba0044a443110eb9
Autor:
Jacob Handlos Grauslund, Morten Orebo Holmström, Evelina Martinenaite, Thomas Landkildehus Lisle, Hannah Jorinde Glöckner, Daniel El Fassi, Uffe Klausen, Rasmus E. J. Mortensen, Nicolai Jørgensen, Lasse Kjær, Vibe Skov, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionArginase-1 (ARG1) and Programed death ligand-1 (PD-L1) play a vital role in immunosuppression in myeloproliferative neoplasms (MPNs) and directly inhibit T-cell activation and proliferation. We previously identified spontaneous T-cell res
Externí odkaz:
https://doaj.org/article/5bb1896ca9234691adc0750d751600e6
Autor:
Davide Ferrari, Stefania Gessi, Stefania Merighi, Manuela Nigro, Alessia Travagli, Jorge S. Burns
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/a8af3b9e904d4b0cab1699523fbd8d34
Akademický článek
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Autor:
Valentina Cazzetta, Elena Bruni, Sara Terzoli, Claudia Carenza, Sara Franzese, Rocco Piazza, Paolo Marzano, Matteo Donadon, Guido Torzilli, Matteo Cimino, Matteo Simonelli, Lorenzo Bello, Anna Villa, Likai Tan, Sarina Ravens, Immo Prinz, Domenico Supino, Federico S. Colombo, Enrico Lugli, Emanuela Marcenaro, Eric Vivier, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109871- (2021)
Summary: Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer.
Externí odkaz:
https://doaj.org/article/05645d72a7ba409498bd2a6ec58b97fb
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cancer is one of the leading causes of death and a major public health problem all over the world. Immunotherapy is becoming a revolutionary clinical management for various cancer types. Restoration of aberrant immune surveillance on cancers has achi
Externí odkaz:
https://doaj.org/article/1d88203204a5473fa76c648e8bfb0e71